Toward Creation of a Universal NMR Database for Stereochemical Assignment:  Complete Structure of the Desertomycin/Oasomycin Class of Natural Products

2001 ◽  
Vol 123 (9) ◽  
pp. 2076-2078 ◽  
Author(s):  
Yoshihisa Kobayashi ◽  
Choon-Hong Tan ◽  
Yoshito Kishi
Keyword(s):  
Natural Products ◽  
Complete Structure ◽  
Stereochemical Assignment

Stereochemical assignment of 2,3-epoxy-2-methylbutanoate esters in natural products

1999 ◽  
Vol 10 (5) ◽  
pp. 221-237 ◽  
Author(s):  
J. Martín Torres-Valencia ◽  
Carlos M. Cerda-García-Rojas ◽  
Pedro Joseph-Nathan
Keyword(s):  
Natural Products ◽  
Stereochemical Assignment

scholarly journals Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

2005 ◽  
Vol 201 (5) ◽  
pp. 713-722 ◽  
Author(s):  
Makoto Arita ◽  
Francesca Bianchini ◽  
Julio Aliberti ◽  
Alan Sher ◽  
Nan Chiang ◽  
...  
Keyword(s):  
Specific Binding ◽  
Nuclear Factor Κb ◽  
Receptor Activation ◽  
Lipid Mediator ◽  
Omega 3 ◽  
Complete Structure ◽  
Small Interference Rna ◽  
Stereochemical Assignment ◽  
Beneficial Effects ◽  
Human Disorders

The essential fatty acid eicosapentaenoic acid (EPA) present in fish oils displays beneficial effects in a range of human disorders associated with inflammation including cardiovascular disease. Resolvin E1 (RvE1), a new bioactive oxygenated product of EPA, was identified in human plasma and prepared by total organic synthesis. Results of bioaction and physical matching studies indicate that the complete structure of RvE1 is 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA. At nanomolar levels, RvE1 dramatically reduced dermal inflammation, peritonitis, dendritic cell (DC) migration, and interleukin (IL) 12 production. We screened receptors and identified one, denoted earlier as ChemR23, that mediates RvE1 signal to attenuate nuclear factor–κB. Specific binding of RvE1 to this receptor was confirmed using synthetic [3H]-labeled RvE1. Treatment of DCs with small interference RNA specific for ChemR23 sharply reduced RvE1 regulation of IL-12. These results demonstrate novel counterregulatory responses in inflammation initiated via RvE1 receptor activation that provide the first evidence for EPA-derived potent endogenous agonists of antiinflammation.

Long-range carbon-proton coupling constants for stereochemical assignment of acyclic structures in natural products: Configuration of the C5C9 portion of maitotoxin

1996 ◽  
Vol 37 (8) ◽  
pp. 1269-1272 ◽  
Author(s):  
Nobuaki Matsumori ◽  
Taro Nonomura ◽  
Makoto Sasaki ◽  
Michio Murata ◽  
Kazuo Tachibana ◽  
...  
Keyword(s):  
Natural Products ◽  
Long Range ◽  
Coupling Constants ◽  
Stereochemical Assignment ◽  
Proton Coupling

scholarly journals Discovery of the Antibiotic Polyketide Tatiomicin via a Genomics Guided Analysis of Amycolatopsis sp. DEM30355

2020 ◽  
Author(s):  
Bernhard Kepplinger ◽  
Joseph Cowell ◽  
Stephanie Morton-Laing ◽  
Corinne Wills ◽  
Emma Marrs ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Natural Products ◽  
Computational Methods ◽  
Antibiotic Activity ◽  
Structural Elucidation ◽  
Gram Positive ◽  
Methicillin Resistant ◽  
Stereochemical Assignment ◽  
Bioactive Natural Products ◽  
Gram Positive Bacteria

The application of genomic techniques to the investigation of understudied species of actinobacteria provides an expedited route to the discovery of new bioactive natural products. We report the isolation of the antibiotic polyketide tatiomicin, through a genomics and bioactivity informed analysis of the metabolome of the extremophile <i>Amycolatopsis</i> sp. DEM30355. Structural elucidation including absolute stereochemical assignment was performed using complementary crystallographic, spectroscopic and computational methods. Tatiomicin shows antibiotic activity against Gram-positive bacteria, including Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA).

ChemInform Abstract: Stereochemical Assignment of 2,3-Epoxy-2-methylbutanoate Esters in Natural Products

ChemInform ◽  
2010 ◽  
Vol 31 (7) ◽  
pp. no-no
Author(s):  
J. Martin Torres-Valencia ◽  
Carlos M. Cerda-Garcia-Rojas ◽  
Pedro Joseph-Nathan
Keyword(s):  
Natural Products ◽  
Stereochemical Assignment

scholarly journals Discovery of the Antibiotic Polyketide Tatiomicin via a Genomics Guided Analysis of Amycolatopsis sp. DEM30355

2020 ◽  
Author(s):  
Bernhard Kepplinger ◽  
Joseph Cowell ◽  
Stephanie Morton-Laing ◽  
Corinne Wills ◽  
Emma Marrs ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Natural Products ◽  
Computational Methods ◽  
Antibiotic Activity ◽  
Structural Elucidation ◽  
Gram Positive ◽  
Methicillin Resistant ◽  
Stereochemical Assignment ◽  
Bioactive Natural Products ◽  
Gram Positive Bacteria

The application of genomic techniques to the investigation of understudied species of actinobacteria provides an expedited route to the discovery of new bioactive natural products. We report the isolation of the antibiotic polyketide tatiomicin, through a genomics and bioactivity informed analysis of the metabolome of the extremophile <i>Amycolatopsis</i> sp. DEM30355. Structural elucidation including absolute stereochemical assignment was performed using complementary crystallographic, spectroscopic and computational methods. Tatiomicin shows antibiotic activity against Gram-positive bacteria, including Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA).

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