Total synthesis of 2'-deoxymugineic acid, the metal chelator excreted from wheat root

1981 ◽  
Vol 103 (9) ◽  
pp. 2409-2410 ◽  
Author(s):  
Yasufumi Ohfune ◽  
Masako Tomita ◽  
Kyosuke Nomoto
Keyword(s):  
Total Synthesis ◽  
Wheat Root ◽  
Metal Chelator ◽  
Deoxymugineic Acid

ChemInform Abstract: Total Synthesis of 2′-Deoxymugineic Acid and Nicotianamine.

ChemInform ◽  
2010 ◽  
Vol 25 (52) ◽  
pp. no-no
Author(s):  
F. MATSUURA ◽  
Y. HAMADA ◽  
T. SHIOIRI
Keyword(s):  
Total Synthesis ◽  
Deoxymugineic Acid

Total synthesis of 2′-deoxymugineic acid and nicotianamine

Tetrahedron ◽  
1994 ◽  
Vol 50 (31) ◽  
pp. 9457-9470 ◽  
Author(s):  
Fumiyoshi Matsuura ◽  
Yasumasa Hamada ◽  
Takayuki Shioiri
Keyword(s):  
Total Synthesis ◽  
Deoxymugineic Acid

scholarly journals Investigation of Nicotianamine and 2′ Deoxymugineic Acid as Enhancers of Iron Bioavailability in Caco-2 Cells

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1502 ◽  
Author(s):  
Jesse T. Beasley ◽  
Jonathan J. Hart ◽  
Elad Tako ◽  
Raymond P. Glahn ◽  
Alexander A. T. Johnson
Keyword(s):  
Ferric Iron ◽  
Cell System ◽  
Iron Bioavailability ◽  
Low Molecular Weight ◽  
Uptake Inhibition ◽  
Plant Foods ◽  
Metal Chelator ◽  
Important Target ◽  
Cereal Grain ◽  
Deoxymugineic Acid

Nicotianamine (NA) is a low-molecular weight metal chelator in plants with high affinity for ferrous iron (Fe2+) and other divalent metal cations. In graminaceous plant species, NA serves as the biosynthetic precursor to 2′ deoxymugineic acid (DMA), a root-secreted mugineic acid family phytosiderophore that chelates ferric iron (Fe3+) in the rhizosphere for subsequent uptake by the plant. Previous studies have flagged NA and/or DMA as enhancers of Fe bioavailability in cereal grain although the extent of this promotion has not been quantified. In this study, we utilized the Caco-2 cell system to compare NA and DMA to two known enhancers of Fe bioavailability—epicatechin (Epi) and ascorbic acid (AsA)—and found that both NA and DMA are stronger enhancers of Fe bioavailability than Epi, and NA is a stronger enhancer of Fe bioavailability than AsA. Furthermore, NA reversed Fe uptake inhibition by Myricetin (Myr) more than Epi, highlighting NA as an important target for biofortification strategies aimed at improving Fe bioavailability in staple plant foods.

Total synthesis of Δ9(12)-capnellene-8α,10α-diol

1982 ◽  
Vol 23 (52) ◽  
pp. 5471-5474
Author(s):  
G Pattenden
Keyword(s):  
Total Synthesis

Total synthesis of melleumins A and B and their analogs: Determination of stereochemistry and Wnt signal inhibitory activity

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
M Ishibashi ◽  
S Hanazawa ◽  
Y Uchino ◽  
X Li ◽  
MA Arai
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Wnt Signal

Progress Toward The Total Synthesis Of The Marine Natural Product Karlotoxin 5

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
M Albadry ◽  
Y Zou ◽  
Y Takahashi ◽  
A Waters ◽  
M Hossein ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Marine Natural Product
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