Tautomerism of phenindione, 2-phenyl-1,3-indandione, in dipolar aprotic/hydrocarbon solvent mixtures

1982 ◽  
Vol 104 (24) ◽  
pp. 6672-6680 ◽  
Author(s):  
J. D. Pipkin ◽  
V. J. Stella
Keyword(s):  
Solvent Mixtures ◽  
Hydrocarbon Solvent

Biological monitoring of experimental human exposure to hydrocarbon solvent mixtures

2006 ◽  
Vol 162 (2-3) ◽  
pp. 263-269 ◽  
Author(s):  
Holger Zimmer ◽  
Holger Uhlich ◽  
Udo Knecht ◽  
Gerhard Triebig
Keyword(s):  
Biological Monitoring ◽  
Human Exposure ◽  
Solvent Mixtures ◽  
Hydrocarbon Solvent ◽  
Experimental Human Exposure

Phase equilibria in solutions of butyl rubber in monomer-hydrocarbon solvent mixtures

1989 ◽  
Vol 31 (11) ◽  
pp. 2625-2631 ◽  
Author(s):  
L.N. Vladykin ◽  
P.G. Pautov ◽  
V.P. Budtov
Keyword(s):  
Phase Equilibria ◽  
Butyl Rubber ◽  
Solvent Mixtures ◽  
Hydrocarbon Solvent

Biocatalytic oxidation of polycyclic aromatic hydrocarbons in media containing organic solvents

1997 ◽  
Vol 36 (10) ◽  
pp. 37-44 ◽  
Author(s):  
Eduardo Torres ◽  
Raunel Tinoco ◽  
Rafael Vazquez-Duhalt
Keyword(s):  
Cytochrome C ◽  
Organic Solvents ◽  
Oxidation Mechanism ◽  
Site Directed Mutagenesis ◽  
Solvent Mixtures ◽  
Reaction Products ◽  
Prosthetic Group ◽  
Mass Transfer Limitation ◽  
Polycyclic Aromatic ◽  
Protein Environment

Lignin peroxidase, cytochrome c and haemoglobin were tested for oxidation of polycyclic aromatic hydrocarbon (PAH) in the presence of hydrogen peroxide. The reaction mixture Contained water-miscible organic solvents in order to reduce the mass transfer limitation of hydrophobic substrates. The reaction products from all three haemoproteins were mainly quinones, suggesting the same oxidation mechanism for the three biocatalysts. The haeme prosthetic group must have located in a protein environment for it to catalyze these reactions, and only certain types of protein environment are able to induce this type of haemebased catalytic activity. The solvent hydrophobicity is a factor affecting the biocatalysis in organic media. Substrate partitioning between the active site (haeme) and the bulk solvent is the main factor of the biocatalytic behaviour in organic solvent mixtures. Site-directed mutagenesis of yeast cytochrome c significantly altered the kinetic behaviour of the protein. The Gly82;Thr 102 variant was 10 times more active and showed a catalytic efficiency 10-fold greater than the wild-type iso-1-cytochrome c. These results suggest that it is possible to design a new biocatalyst for environmental purposes.

Solubility enhancement, solvent effect and thermodynamic analysis of pazopanib in co-solvent mixtures

2021 ◽  
Vol 155 ◽  
pp. 106343
Author(s):  
Hongwei Shi ◽  
Yong Xie ◽  
Jigui Xu ◽  
Jun Zhu ◽  
Cong Wang ◽  
...  
Keyword(s):  
Solvent Effect ◽  
Thermodynamic Analysis ◽  
Solubility Enhancement ◽  
Solvent Mixtures
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