Studies on vitamin D (calciferol) and its analogs. 23. Effect of 3-methyl substituents on the thermal [1,5]- and [1,7]-sigmatropic hydrogen shifts of vinylallenes and other seco steroids related to vitamin D: synthesis of 3-methyl- and 3,3-dimethyl-substituted analogs of 3-deoxy-1.alpha.,25-dihydroxyvitamin D3

1982 ◽  
Vol 104 (22) ◽  
pp. 6099-6105 ◽  
Author(s):  
Gregory A. Leyes ◽  
William H. Okamura
Keyword(s):  
Vitamin D ◽  
Dihydroxyvitamin D3 ◽  
Hydrogen Shifts

ChemInform Abstract: Efficient and Versatile Synthesis of Novel 2α-Substituted 1α,25-Dihydroxyvitamin D3 Analogues and Their Docking to Vitamin D Receptors.

ChemInform ◽  
2010 ◽  
Vol 33 (25) ◽  
pp. no-no
Author(s):  
Yoshitomo Suhara ◽  
Ken-ichi Nihei ◽  
Masaaki Kurihara ◽  
Atsushi Kittaka ◽  
Kentaro Yamaguchi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dihydroxyvitamin D3 ◽  
Vitamin D Receptors

Increased bone volume and reduced bone turnover in vitamin D-replete rabbits by the administration of 24R,25-dihydroxyvitamin D3

Bone ◽  
1992 ◽  
Vol 13 (3) ◽  
pp. 229-236 ◽  
Author(s):  
T. Nakamura ◽  
K. Suzuki ◽  
T. Hirai ◽  
T. Kurokawa ◽  
H. Orimo
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Bone Volume ◽  
Dihydroxyvitamin D3

Metabolism of vitamin D in patients with primary biliary cirrhosis and alcoholic liver disease

1985 ◽  
Vol 69 (5) ◽  
pp. 561-570 ◽  
Author(s):  
E. Barbara Mawer ◽  
H. J. Klass ◽  
T. W. Warnes ◽  
Jacqueline L. Berry
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Primary Biliary Cirrhosis ◽  
Alcoholic Liver Disease ◽  
Vitamin D3 ◽  
Control Group ◽  
Biliary Cirrhosis ◽  
Vitamin D2 ◽  
Dihydroxyvitamin D3 ◽  
Poor Renal Function

1. The metabolism of isotopically labelled vitamin D2 and D3 has been investigated in eight patients with primary biliary cirrhosis and in five controls. The concentration of labelled vitamin D2 was lower than that of vitamin D3 in serum of patients with primary biliary cirrhosis on days 1 and 2 after intravenous injection (P < 0.005 and P < 0.05, respectively) but no difference was seen in controls. 2. Similar amounts of labelled 25-hydroxyvitamin D2 and D3 were seen in serum of the control group; the same pattern was observed in the primary biliary cirrhosis group, and no significant differences were observed between the two groups. 3. In both control and primary biliary cirrhosis groups, the serum concentration of labelled 24,25-dihydroxyvitamin D2 exceeded that of 24,25-dihydroxyvitamin D3 (significant for controls on day 2, P < 0.02) but concentrations in the two groups were not different. 4. Concentrations of labelled 25,26-dihydroxyvitamin D3 were significantly higher than those of 25,26-dihydroxyvitamin D2 in the primary biliary cirrhosis group at all times and in the control group on days 2 and 3. Both 25,26-dihydroxyvitamin D2 and D3 were higher in the serum of patients with primary biliary cirrhosis than in controls (significant on day 1, P < 0.05). 5. Urinary excretion over days 0–3 of radioactivity from both vitamins D2 and D3 was significantly higher in the primary biliary cirrhosis group than in controls: 12.03 vs 1.80% for vitamin D2 and 8.98 vs 1.76% for vitamin D3(P < 0.005). Vitamin D2-derived urinary radioactivity in primary biliary cirrhosis correlated strongly with serum bilirubin (P = 0.005). 6. The metabolism of labelled vitamin D3 was studied in seven patients with alcoholic liver disease, three of whom showed low serum concentrations of labelled 25-hydroxyvitamin D3 suggesting impaired hepatic synthesis. The 25-hydroxylation response was quantified as the relative index of 25-hydroxylation and was significantly related to two other indices of liver function. It is concluded that impaired 25-hydroxylation of vitamin D may occur in alcoholic liver disease and results from hepatocellular dysfunction. 7. Less than the predicted amounts of 1,25-dihydroxyvitamin D3 were produced in four of the seven patients with alcoholic liver disease; this defect may be attributable in part to decreased precursor 25-hydroxyvitamin D and to poor renal function.

Sign in / Sign up

Export Citation Format

Share Document