New mechanism based serine protease inhibitors: inhibition of human leukocyte elastase, porcine pancreatic elastase, human leukocyte cathepsin G, and chymotrypsin by 3-chloroisocoumarin and 3,3-dichlorophthalide

J. Wade Harper; Keiji Hemmi; James C. Powers

doi:10.1021/ja00359a042

New mechanism based serine protease inhibitors: inhibition of human leukocyte elastase, porcine pancreatic elastase, human leukocyte cathepsin G, and chymotrypsin by 3-chloroisocoumarin and 3,3-dichlorophthalide

Journal of the American Chemical Society ◽

10.1021/ja00359a042 ◽

1983 ◽

Vol 105 (21) ◽

pp. 6518-6520 ◽

Cited By ~ 19

Author(s):

J. Wade Harper ◽

Keiji Hemmi ◽

James C. Powers

Keyword(s):

Serine Protease ◽

Protease Inhibitors ◽

Human Leukocyte ◽

Cathepsin G ◽

Serine Protease Inhibitors ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Human Leukocyte Elastase ◽

Porcine Pancreatic Elastase

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A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted benzoxazinones, quinazolines, and anthranilates.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)34638-6 ◽

1982 ◽

Vol 257 (9) ◽

pp. 5085-5091

Author(s):

T Teshima ◽

J C Griffin ◽

J C Powers

Keyword(s):

Serine Protease ◽

Protease Inhibitors ◽

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

New Class ◽

Human Leukocyte Elastase ◽

Porcine Pancreatic Elastase ◽

Chymotrypsin A

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Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin A.alpha., and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates

Biochemistry ◽

10.1021/bi00308a023 ◽

1984 ◽

Vol 23 (13) ◽

pp. 2995-3002 ◽

Cited By ~ 78

Author(s):

J. Wade Harper ◽

Robert R. Cook ◽

C. Justine Roberts ◽

Beth H. McLaughlin ◽

James C. Powers

Keyword(s):

Active Site ◽

Serine Proteases ◽

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Site Mapping ◽

Human Leukocyte Elastase ◽

Porcine Pancreatic Elastase ◽

And Staphylococcus Aureus

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Inhibition of human leukocyte elastase, cathepsin G, chymotrypsin A.alpha., and porcine pancreatic elastase with substituted isobenzofuranones and benzopyrandiones

Biochemistry ◽

10.1021/bi00329a006 ◽

1985 ◽

Vol 24 (8) ◽

pp. 1841-1848 ◽

Cited By ~ 17

Author(s):

Keiji Hemmi ◽

J. Wade Harper ◽

James C. Powers

Keyword(s):

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Human Leukocyte Elastase ◽

Porcine Pancreatic Elastase

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Studies on reactivity of human leukocyte elastase, cathepsin G, and porcine pancreatic elastase toward peptides including sequences related to the reactive site of .alpha.1-protease inhibitor (.alpha.1-antitrypsin)

Biochemistry ◽

10.1021/bi00558a013 ◽

1980 ◽

Vol 19 (17) ◽

pp. 3973-3978 ◽

Cited By ~ 81

Author(s):

Brian McRae ◽

Kiichiro Nakajima ◽

James Travis ◽

James C. Powers

Keyword(s):

Protease Inhibitor ◽

Human Leukocyte ◽

Cathepsin G ◽

Reactive Site ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Human Leukocyte Elastase ◽

Porcine Pancreatic Elastase ◽

Alpha 1 Antitrypsin

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Amino acids and peptides. XXX. Synthesis of eglin c(41-49) and eglin c(60-63) and examination of their inhibitory activity towards human leukocyte elastase, cathepsin G, porcine pancreatic elastase and .ALPHA.-chymotrypsin.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.39.184 ◽

1991 ◽

Vol 39 (1) ◽

pp. 184-186 ◽

Cited By ~ 2

Author(s):

Satoshi TSUBOI ◽

Miho TAKEDA ◽

Yoshio OKADA ◽

Yoko NAGAMATSU ◽

Junichiro YAMAMOTO

Keyword(s):

Amino Acids ◽

Inhibitory Activity ◽

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Human Leukocyte Elastase ◽

Eglin C ◽

Porcine Pancreatic Elastase

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Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G Inhibition with peptide chloromethyl ketones

Biochimica et Biophysica Acta (BBA) - Enzymology ◽

10.1016/0005-2744(77)90203-0 ◽

1977 ◽

Vol 485 (1) ◽

pp. 156-166 ◽

Cited By ~ 136

Author(s):

James C. Powers ◽

B.Frank Gupton ◽

A.Dale Harley ◽

Norikazu Nishino ◽

Ronald J. Whitley

Keyword(s):

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Human Leukocyte Elastase ◽

Porcine Pancreatic Elastase

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Specificity and reactivity of human leukocyte elastase, porcine pancreatic elastase, human granulocyte cathepsin G, and bovine pancreatic chymotrypsin with arylsulfonyl fluorides. Discovery of a new series of potent and specific irreversible elastase inhibitors.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)34637-4 ◽

1982 ◽

Vol 257 (9) ◽

pp. 5077-5084 ◽

Cited By ~ 2

Author(s):

T Yoshimura ◽

L N Barker ◽

J C Powers

Keyword(s):

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Human Leukocyte Elastase ◽

Porcine Pancreatic Elastase

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ChemInform Abstract: Inhibition of Human Leukocyte Elastase, Porcine Pancreatic Elastase and Chymotrypsin by Elasnin and Other 4-Hydroxy-2-pyrones.

Chemischer Informationsdienst ◽

10.1002/chin.198613191 ◽

1986 ◽

Vol 17 (13) ◽

Author(s):

R. W. SPENCER ◽

L. J. COPP ◽

J. R. PFISTER

Keyword(s):

Human Leukocyte ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Human Leukocyte Elastase ◽

Porcine Pancreatic Elastase

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Comparison of the Elastolytic Effects of Human Leukocyte Elastase and Porcine Pancreatic Elastase

Elastin and Elastic Tissue - Advances in Experimental Medicine and Biology ◽

10.1007/978-1-4684-9093-0_21 ◽

1977 ◽

pp. 249-258 ◽

Cited By ~ 10

Author(s):

Robert M. Senior ◽

David R. Bielefeld ◽

Barry C. Starcher

Keyword(s):

Human Leukocyte ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Human Leukocyte Elastase ◽

Porcine Pancreatic Elastase

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ChemInform Abstract: AMINO ACID DERIVED LATENT ISOCYANATES: IRREVERSIBLE INACTIVATION OF PORCINE PANCREATIC ELASTASE AND HUMAN LEUKOCYTE ELASTASE

Chemischer Informationsdienst ◽

10.1002/chin.198524212 ◽

1985 ◽

Vol 16 (24) ◽

Author(s):

W. C. GROUTAS ◽

W. R. ABRAMS ◽

M. C. THEODORAKIS ◽

A. M. KASPER ◽

S. A. RUDE ◽

...

Keyword(s):

Amino Acid ◽

Human Leukocyte ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Human Leukocyte Elastase ◽

Porcine Pancreatic Elastase

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