On the mechanism of action of superoxide dismutase: a theoretical study

1984 ◽  
Vol 106 (19) ◽  
pp. 5710-5714 ◽  
Author(s):  
Roman Osman ◽  
Harold Basch
Keyword(s):  
Superoxide Dismutase ◽  
Mechanism Of Action ◽  
Theoretical Study

scholarly journals The involvement of the bridging imidazolate in the catalytic mechanism of action of bovine superoxide dismutase

1977 ◽  
Vol 167 (1) ◽  
pp. 271-274 ◽  
Author(s):  
M E McAdam ◽  
E M Feilden ◽  
F Lavelle ◽  
L Calabrese ◽  
D Cocco ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Nitrogen Atom ◽  
Mechanism Of Action ◽  
Pulse Radiolysis ◽  
Catalytic Mechanism ◽  
Catalytic Reduction ◽  
Rapid Change ◽  
Proton Donor ◽  
Spectral Changes ◽  
Rapid Protonation

The pulse-radiolysis method has been used to study the catalytic mechanism of O2 leads to dismutation by the Co(II)-substituted bovine erythrocuprein (superoxide dismutase, EC 1.15.1.1). Catalysis is accompanied by spectral changes that may be interpreted in terms of rapid protonation and deprotonation of the Cu-facing nitrogen atom of the imidazolate that bridges the Cu(II) and the Co(II) [or Zn(II)] in the oxidized enzyme. This rapid change permits the possibility that the imidazole is a proton donor in the catalytic reduction of O2 leads to.

On the Effect of a Point Mutation on the Reactivity of CuZn Superoxide Dismutase:  A Theoretical Study

2006 ◽  
Vol 110 (14) ◽  
pp. 7538-7544 ◽  
Author(s):  
Andrea Amadei ◽  
Maira D'Alessandro ◽  
Maurizio Paci ◽  
Alfredo Di Nola ◽  
Massimiliano Aschi
Keyword(s):  
Superoxide Dismutase ◽  
Point Mutation ◽  
Theoretical Study ◽  
Cuzn Superoxide Dismutase

scholarly journals Comparative Transcriptome Analysis Reveals the Mechanism Related to Fluazinam Stress of Panonychus citri (Acarina: Tetranychidae)

Insects ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 730
Author(s):  
Yi Shang ◽  
Yanbo Wang ◽  
Jianyu Deng ◽  
Xunyue Liu ◽  
Yihao Fang ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Mechanism Of Action ◽  
Good Control ◽  
Glutathione S Transferase ◽  
Control Effect ◽  
Panonychus Citri ◽  
Transcriptomic Sequencing ◽  
Cytochrome P450 Genes ◽  
Differential Expression Genes ◽  
And Control

The use of a large number of chemical acaricides to control these pest mites has led to an increasing problem of pesticide resistance, which has always been the difficulty in integrated pest management (IPM). Fluazinam has a good control effect on Panonychus citri, the serious pest on citrus; however, we only know the mechanism of action of fluazinam as a fungicide and its mechanism of action on mites remains unclear. Through analysis using Illumina high-throughput transcriptomic sequencing and differential expression genes in P. citri treated with fluazinam, 59 cytochrome P450 genes, 23 glutathione s-transferase genes, five carboxylate esterase genes, 11 superoxide dismutase genes and 15 catalase genes were identified. The Gene Ontology enrichment and the enrichment of KEGG results showed that the treatment were enrichment for redox enzyme pathways. Evaluating the efficacy of fluazinam, and analyzing the transcriptome data of P. citri under fluazinam stress, potentially provide a new agent for prevention and control of P. citri, and also preliminary research results for exploring the mechanism of action of fluazinam on P. citri. Given the up-regulated expression levels of genes for Mn-superoxide dismutase and catalase, we speculate that they play an important role in fluazinam-stress action on P. citri.

scholarly journals Antioxidant and antiaggregant effects of covalent bienzyme superoxide dismutase - chondroitin sulfate - catalase conjugate in platelet interactions

2012 ◽  
Vol 58 (3) ◽  
pp. 300-309
Author(s):  
A.V. Vavaev ◽  
L.I. Buryachkovskaya ◽  
E.G. Tischenko ◽  
I.A. Uchitel ◽  
A.V. Maksimenko
Keyword(s):  
Hydrogen Peroxide ◽  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Platelet Aggregation ◽  
Chondroitin Sulfate ◽  
Mechanism Of Action ◽  
Inhibitory Action ◽  
Induced Aggregation ◽  
Dose Dependent ◽  
Aggregation Of Platelets

A covalent bienzyme superoxide dismutase-chondroitin sulfate-catalase conjugate (SOD-CHS-CAT) demonstrated the dose-dependent inhibitory action on induced aggregation of platelets in the presence of hydrogen peroxide. Antioxidant activity of SOD-CHS-CAT appeared at much lower doses than for other CAT derivatives. We detected the antiaggregation effect of SOD-CHS-CAT for platelet aggregation induced by ADP, serotonin, TRAP (with their different mechanism of action). Novel properties of SOD-CHS-CAT confirmed with its action agains spread-eagle platelets on glass surface. The new characteristics of SOD-CHS-CAT conjugate underline the prospects of its biopharmaceutical development for antioxidant therapy.

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