Kinetic isotope effects and tunneling in cyclic double and triple proton transfer between acetic acid and methanol in tetrahydrofuran studied by dynamic proton and deuteron NMR spectroscopy

1984 ◽  
Vol 106 (4) ◽  
pp. 869-879 ◽  
Author(s):  
Detlef Gerritzen ◽  
Hans Heinrich Limbach
Keyword(s):  
Acetic Acid ◽  
Nmr Spectroscopy ◽  
Proton Transfer ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Kinetic Isotope ◽  
Deuteron Nmr

scholarly journals Heavy-Enzyme Kinetic Isotope Effects on Proton Transfer in Alanine Racemase

2013 ◽  
Vol 135 (7) ◽  
pp. 2509-2511 ◽  
Author(s):  
Michael D. Toney ◽  
Joan Nieto Castro ◽  
Trevor A. Addington
Keyword(s):  
Proton Transfer ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Alanine Racemase ◽  
Enzyme Kinetic ◽  
Kinetic Isotope

α-DEUTERIUM KINETIC ISOTOPE EFFECTS IN SOLVOLYSES OF endo-NORBORNYL p-BROMOBENZENESULFONATE

1965 ◽  
Vol 43 (8) ◽  
pp. 2254-2258 ◽  
Author(s):  
C. C. Lee ◽  
Edward W. C. Wong
Keyword(s):  
Acetic Acid ◽  
Formic Acid ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Aqueous Dioxane ◽  
Kinetic Isotope ◽  
Different Temperatures

endo-Norbornyl-2-d p-bromobenzenesulfonate was synthesized and the isotope effects, as measured by kH/kD, were determined over a range of temperatures for solvolyses in 30% water – 70% dioxane, acetic acid, and formic acid. Values of kH/kD are of the order of 1.20. The data appear to indicate slightly higher isotope effects as the solvents are changed from aqueous dioxane to acetic acid to formic acid, as well as somewhat higher isotope effects at lower temperatures. Possible mechanistic implications of these results are presented. Relative titrimetric acetolysis rates, kexo/kendo, at different temperatures, and enthalpies and entropies of activation for these acetolyses are evaluated and discussed.

Kinetic Isotope Effects in Multiple Proton Transfer

2005 ◽  
pp. 521-548 ◽  
Author(s):  
Willem Siebrand ◽  
Zorka Smedarchina ◽  
Antonio Fernández-Ramos
Keyword(s):  
Proton Transfer ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Kinetic Isotope
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