Photoresponsive molecular tweezers. Photoregulated ion capture and release using thioindigo derivatives having ethylenedioxy side groups

1985 ◽  
Vol 107 (4) ◽  
pp. 1024-1028 ◽  
Author(s):  
Masahiro Irie ◽  
Masatoshi Kato
Keyword(s):  
Molecular Tweezers ◽  
Capture And Release

scholarly journals Sulfoxide hemithioindigo tweezers – visible light addressable capture and release

2021 ◽  
Author(s):  
Thomas Bartelmann ◽  
Frederik Gnannt ◽  
Max Zitzmann ◽  
Peter Mayer ◽  
Henry Dube
Keyword(s):  
Visible Light ◽  
Sulfur Atom ◽  
Molecular Tweezers ◽  
Capture And Release ◽  
Property Profile

Hemithioindigo based molecular tweezers with a comprehensively improved property profile are obtained by simple oxidation of the sulfur atom.

Biomimetic recognition strategy for efficient capture and release of circulating tumor cells

2021 ◽  
Vol 188 (6) ◽  
Author(s):  
Ji Zheng ◽  
Dayong Li ◽  
Jin Jiao ◽  
Chengjie Duan ◽  
Youjing Gong ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Capture And Release

scholarly journals Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Annika Meiners ◽  
Sandra Bäcker ◽  
Inesa Hadrović ◽  
Christian Heid ◽  
Christine Beuck ◽  
...  
Keyword(s):  
Nuclear Export ◽  
Rational Design ◽  
Nuclear Export Signal ◽  
Signal Interference ◽  
Receptor Interaction ◽  
Dual Function ◽  
Experimental Proof ◽  
Molecular Tweezers ◽  
Recognition Element ◽  
Dynamics Simulations

AbstractSurvivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. This protein–protein interaction represents an attractive target in cancer research and therapy. Here, we report a sophisticated strategy addressing Survivin’s nuclear export signal (NES), the binding site of CRM1, with advanced supramolecular tweezers for lysine and arginine. These were covalently connected to small peptides resembling the natural, self-complementary dimer interface which largely overlaps with the NES. Several biochemical methods demonstrated sequence-selective NES recognition and interference with the critical receptor interaction. These data were strongly supported by molecular dynamics simulations and multiscale computational studies. Rational design of lysine tweezers equipped with a peptidic recognition element thus allowed to address a previously unapproachable protein surface area. As an experimental proof-of-principle for specific transport signal interference, this concept should be transferable to any protein epitope with a flanking well-accessible lysine.

Clog-free cell filtration using resettable cell traps

Lab on a Chip ◽  
2014 ◽  
Vol 14 (15) ◽  
pp. 2657-2665 ◽  
Author(s):  
William Beattie ◽  
Xi Qin ◽  
Lin Wang ◽  
Hongshen Ma
Keyword(s):  
High Throughput ◽  
Cell Separation ◽  
Free Cell ◽  
Separation Mechanism ◽  
Cell Filtration ◽  
Capture And Release

A microfluidic cell separation mechanism created using constrictions with adjustable size that can selectively capture and release cells, thereby enabling high throughput size and deformability based cell separation without clogging.

Molecular Tweezers: Synthesis and Formation of Host-Guest Complexes

2010 ◽  
Vol 2010 (28) ◽  
pp. 5503-5508 ◽  
Author(s):  
Béatrice Legouin ◽  
Maud Gayral ◽  
Philippe Uriac ◽  
Jean-François Cupif ◽  
Nicolas Levoin ◽  
...  
Keyword(s):  
Molecular Tweezers

scholarly journals Molecular Complexation of Arenediazonium Ions by a Calix[4]arene Possessing Two Ester Groups: Molecular Tweezers

2004 ◽  
Vol 53 (6) ◽  
pp. 313-317 ◽  
Author(s):  
Takashi ARIMURA ◽  
Takuya NISHIOKA ◽  
Seiji IDE ◽  
Satoshi KUMAMOTO ◽  
Shigeo MURATA ◽  
...  
Keyword(s):  
Molecular Tweezers ◽  
Molecular Complexation

Using molecular tweezers to move and image nanoparticles

Nanoscale ◽  
2013 ◽  
Vol 5 (10) ◽  
pp. 4070 ◽  
Author(s):  
Haimei Zheng
Keyword(s):  
Molecular Tweezers
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