Conformational energy calculations and proton nuclear Overhauser enhancements reveal a unique conformation for blood group A oligosaccharides

1986 ◽  
Vol 108 (20) ◽  
pp. 6168-6173 ◽  
Author(s):  
C. Allen. Bush ◽  
Zhen Yi. Yan ◽  
B. N. Narasinga. Rao
Keyword(s):  
Blood Group ◽  
Conformational Energy ◽  
Energy Calculations ◽  
Blood Group A ◽  
Conformational Energy Calculations ◽  
Group A ◽  
Nuclear Overhauser

Conformational Energy Calculations on the Eosinophil Chemotactic Peptide Analog Val-Gly-Ala-Glu: Comparison of Theory and Experiment

1988 ◽  
Vol 41 (12) ◽  
pp. 1841
Author(s):  
J Bremer ◽  
GL Mendz
Keyword(s):  
Theoretical Calculations ◽  
Chemical Shifts ◽  
Minimum Energy ◽  
Conformational Energy ◽  
Coupling Constants ◽  
Amide Proton ◽  
Energy Calculations ◽  
Peptide Analog ◽  
Conformational Energy Calculations ◽  
Nuclear Overhauser

Conformational energy calculations have been employed to obtain minimum energy conformations of the peptide Val- Gly-Ala-Glu , an analogue of eosinophil chemotactic tetrapeptides. The calculated conformations of the peptide can be described as an ensemble of structures in which the C-terminal and N-terminal regions of the molecule are in close proximity. The charge state of the peptide showed a marked effect on the calculated conformation, and the results were also sensitive to the electrostatic environment. The calculations performed on the dianionic form of the molecule showed good agreement with experimental n.m.r . Data on coupling constants, amide-proton resonance chemical shifts and temperature coefficients, nuclear Overhauser effects, side-chain rotamer populations, and binding of paramagnetic ions, obtained in dimethyl sulfoxide solutions. The calculations demonstrate some of the inherent problems facing theoretical calculations of peptide structure.

Conformational energy calculations on the glycan chain of peptidoglycan

1986 ◽  
Vol 14 (3) ◽  
pp. 629-630 ◽  
Author(s):  
ALAN MARSDEN ◽  
BARRY ROBSON ◽  
J. STUART THOMPSON
Keyword(s):  
Conformational Energy ◽  
Energy Calculations ◽  
Glycan Chain ◽  
Conformational Energy Calculations

scholarly journals Isolation and characterization of novel glycolipids with blood group A-related structures: galactosyl-A and sialosylgalactosyl-A.

1987 ◽  
Vol 262 (29) ◽  
pp. 14228-14234
Author(s):  
H Clausen ◽  
S B Levery ◽  
E D Nudelman ◽  
M Stroud ◽  
M E Salyan ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Group A ◽  
Isolation And Characterization ◽  
Group A

scholarly journals ABO groups can play a role in susceptibility and severity of COVID-19

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
S. Samra ◽  
M. Habeb ◽  
R. Nafae
Keyword(s):  
Blood Group ◽  
Abo Blood Group ◽  
Infection Group ◽  
Mechanically Ventilated ◽  
Blood Group A ◽  
Group A ◽  
Study Population ◽  
Group B ◽  
The Relationship ◽  
Seriously Ill

Abstract Background A few people infected by the coronavirus become seriously ill, while others show little to no signs of the symptoms, or are asymptomatic. Recent researches are pointing to the fact that the ABO blood group might play an important role in a person’s susceptibility and severity of COVID-19 infection. Aim of the study: try to understand the relationship between ABO groups and COVID-19 (susceptibility and severity). Results A total of (507) patients were included in this study. The study population was divided based on the ABO blood group into types A+, A−, B+, AB, O+, and O−. Blood group A was associated with high susceptibility of infection: group A, 381 (75.1%); and less common in group O, 97 (19.2%), group B, 18 (3.5%), and group AB, 11 (2.2%). The severity of COVID-19 infection was common in non-blood group O where (20 (7.1%), 4 (26.7%), 2 (11%), and 1 (9%) in type A+, A−, B+, and AB, respectively), while in type O 3.1%. And mechanically ventilated patients were 22 (5.9%), 2 (13.4%), 2 (11.1%), and 1 (1%). Mortality was high in blood groups A and B, 16 (4.37%) and 1 (5.5%), respectively, while in blood group O, it was 1%. Conclusion The incidence, severity, and mortality of COVID-19 were common in non-blood group O. While blood group O was protected against COVID-19.

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