Identification of the catalytically important amino acid residue resonances in ferric low-spin horseradish peroxidase with nuclear Overhauser effect measurements

1987 ◽  
Vol 109 (24) ◽  
pp. 7516-7525 ◽  
Author(s):  
V. Thanabal ◽  
Jeffrey S. De Ropp ◽  
Gerd N. La Mar
Keyword(s):  
Amino Acid ◽  
Horseradish Peroxidase ◽  
Amino Acid Residue ◽  
Nuclear Overhauser Effect ◽  
Important Amino Acid ◽  
Overhauser Effect ◽  
Nuclear Overhauser ◽  
Important Amino Acid Residue

scholarly journals Mutation of Important Amino Acid Residue of Asp104Lys in Human β1-Adrenergic Receptor Triggers Functional and Constitutive Inactivation

2008 ◽  
Vol 31 (8) ◽  
pp. 1517-1522 ◽  
Author(s):  
Murad Hossain ◽  
Maruf Ahmed ◽  
Mohiuddin Ahmed Bhuiyan ◽  
Masaji Ishiguro ◽  
Takashi Nakamura ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Residue ◽  
Adrenergic Receptor ◽  
Important Amino Acid ◽  
Important Amino Acid Residue

1H NMR studies of [N-MeAib1, Tyr(Me)4]ANGII and [N-MeAib1, Tyr(Me)4, Ile8]ANGII in dimethylsulfoxide by nuclear Overhauser effect (NOE) enhancement spectroscopy: cis-trans Isomerism of the His-Pro bond

1990 ◽  
Vol 55 (4) ◽  
pp. 1106-1111 ◽  
Author(s):  
John Matsoukas ◽  
Paul Cordopatis ◽  
Raghav Yamdagni ◽  
Graham J. Moore
Keyword(s):  
1H Nmr ◽  
Nuclear Overhauser Effect ◽  
Nmr Studies ◽  
Restricted Rotation ◽  
Overhauser Effect ◽  
Major Isomer ◽  
Conformational Properties ◽  
Nuclear Overhauser

The conformational properties of the Sarmesin analogues [N-MeAib1, Tyr(Me)4]ANGII and [N-MeAib1, Tyr(Me)4, Ile8]ANGII in hexadeutero-dimethysulfoxide were investigated by Nuclear Overhauser Effect (NOE) Enhancement Studies. Cis-trans isomers (ratio 1 : 6) due to restricted rotation of the His-Pro bond were observed. Interresidue interactions between the His Cα proton and the two Pro Cδ protons revealed that the major isomer was the trans.

scholarly journals Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1080
Author(s):  
Imran Khan ◽  
Jing Peng ◽  
Zhuangjie Fang ◽  
Wei Liu ◽  
Wenjun Zhang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Nuclear Overhauser Effect ◽  
Inhibition Activity ◽  
Tyrosinase Inhibition ◽  
Bioactive Natural Products ◽  
Chemical Structures ◽  
Overhauser Effect ◽  
Spectroscopic Analyses ◽  
Potential Resource ◽  
Nuclear Overhauser

The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as Tolypocladium cylindrosporum. A new compound, cylindromicin (1), and seven known secondary metabolites (2–8) were isolated from this strain. The chemical structures of these compounds were elucidated by comprehensive spectroscopic analyses. Cylindromicin (1) featured a 3,4-dihydro-2H-pyran skeleton. The absolute configuration of compound 1 was assigned via interpretation of key Nuclear Overhauser Effect Spectroscopy (NOESY) correlations and Electronic Circular Dichroism (ECD) calculation. Cylindromicin (1) exhibited significant tyrosinase inhibition activity. This study highlights Polar fungi as a potential resource for new bioactive natural products.

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