Prorocentrolide, a toxic nitrogenous macrocycle from a marine dinoflagellate, Prorocentrum lima

1988 ◽  
Vol 110 (23) ◽  
pp. 7876-7877 ◽  
Author(s):  
Koichiro. Torigoe ◽  
Michio. Murata ◽  
Takeshi. Yasumoto ◽  
Takashi. Iwashita
Keyword(s):  
Prorocentrum Lima ◽  
Marine Dinoflagellate

scholarly journals Identification of okadaic acid as a toxic component of a marine dinoflagellate Prorocentrum lima.

1982 ◽  
Vol 48 (1) ◽  
pp. 69-72 ◽  
Author(s):  
Yasutaka MURAKAMI ◽  
Yasukatsu OSHIMA ◽  
Takeshi YASUMOTO
Keyword(s):  
Okadaic Acid ◽  
Prorocentrum Lima ◽  
Marine Dinoflagellate ◽  
Toxic Component

Evidence for Reversible Tyrosine Protein Phosphorylation in the Okadaic Acid-Producing Marine Dinoflagellate Prorocentrum lima

1997 ◽  
Vol 44 (2) ◽  
pp. 89-95 ◽  
Author(s):  
JOHN F. DAWSON ◽  
HANNE L. OSTERGAARD ◽  
HEIDE KLIX ◽  
MARION P. BOLAND ◽  
CHARLES F. B. HOLMES
Keyword(s):  
Protein Phosphorylation ◽  
Okadaic Acid ◽  
Prorocentrum Lima ◽  
Marine Dinoflagellate

scholarly journals A Biomass Upscale System for the Marine Dinoflagellate Prorocentrum lima and the Production of Bioactive Lipophilic Toxins

2017 ◽  
Vol 5 (4) ◽  
pp. 479-485 ◽  
Author(s):  
Ioanna Varkitzi ◽  
Kalliopi Pagou ◽  
Christina Pyrgaki ◽  
Ioannis Hatzianestis
Keyword(s):  
Large Scale ◽  
Toxin Production ◽  
Shellfish Poisoning ◽  
Culture Volume ◽  
Prorocentrum Lima ◽  
Marine Dinoflagellate ◽  
Mass Cultures ◽  
Diarrheic Shellfish Poisoning ◽  
Marine Dinoflagellates ◽  
Lipophilic Toxins

Biotechnological applications of toxic marine dinoflagellates include seafood safety and biomedical, pharmaceutical and research purposes of their toxins among other bioproducts and bioactive compounds that they produce. The supply of sufficient quantities of phycotoxins for investigational uses remains in demand. Some of these toxins, available in small amounts, are quite expensive while their chemical synthesis is complex and costly. However, some quantities of these toxins could be produced with mass cultures of the appropriate dinoflagellates, which are however difficult to handle. Prorocentrum lima is a cosmopolitan marine dinoflagellate, which synthesizes toxins that cause a diarrheic syndrome to humans through the consumption of contaminated shellfish and fish (Diarrheic Shellfish Poisoning, DSP). The aim of this study was to design and develop a biomass upscale system for the production of the lipophilic toxins okadaic acid (OA) and dinophysistoxin 1 (DTX1) from the produced biomass of Prorocentrum lima. In our study, P. lima was grown in large scale semi-continuous cultures under controlled laboratory conditions. The maximum biomass produced was 20690 cells/mL. Maximum toxin production was 63.66 ng/mL for OA and 8.07 ng/mL for DTX1. Toxin quota in P. lima cells was 88.7% OA and 11.3% DTX1. The produced culture volume was 300 L and the total volume capacity of the upscale system could reach 500 L.Int. J. Appl. Sci. Biotechnol. Vol 5(4): 479-485

scholarly journals Prorocentin, a New Polyketide from the Marine Dinoflagellate Prorocentrum lima.

ChemInform ◽  
2006 ◽  
Vol 37 (1) ◽  
Author(s):  
Chung-Kuang Lu ◽  
Hong-Nong Chou ◽  
Ching-Kuo Lee ◽  
Tzong-Huei Lee
Keyword(s):  
Prorocentrum Lima ◽  
Marine Dinoflagellate

Limaol: A Polyketide from the Benthic Marine Dinoflagellate Prorocentrum lima

2017 ◽  
Vol 80 (5) ◽  
pp. 1688-1692 ◽  
Author(s):  
A Reum Yang ◽  
Sangbum Lee ◽  
Young Du Yoo ◽  
Hyung Seop Kim ◽  
Eun Ju Jeong ◽  
...  
Keyword(s):  
Prorocentrum Lima ◽  
Marine Dinoflagellate

New polyketides from marine dinoflagellate Amphidinium sp.

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
T Kubota ◽  
T Iwai ◽  
J Kobayashi
Keyword(s):  
Marine Dinoflagellate
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