Reinterpretation of the bicyclomycin-sodium methanethiolate reaction

1988 ◽  
Vol 110 (11) ◽  
pp. 3661-3663 ◽  
Author(s):  
Harold. Kohn ◽  
Syed. Abuzar
Keyword(s):  
Sodium Methanethiolate

scholarly journals Efficacy of Intravenous Hydroxocobalamin for Treatment of Sodium Methanethiolate Exposure in a Swine Model (Sus scrofa) of Severe Methanethiol Toxicity

2020 ◽  
Vol 16 (4) ◽  
pp. 388-397
Author(s):  
Joseph K. Maddry ◽  
R. Madelaine Paredes ◽  
Jennifer Rebeles ◽  
Glen Olson ◽  
Maria Castaneda ◽  
...  
Keyword(s):  
Sus Scrofa ◽  
Swine Model ◽  
Sodium Methanethiolate

scholarly journals Crystal structure of 2,3,5,6-tetrakis[(methylsulfanyl)methyl]pyrazine

2014 ◽  
Vol 70 (9) ◽  
pp. o887-o888 ◽  
Author(s):  
Tokouré Assoumatine ◽  
Helen Stoeckli-Evans
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bonds ◽  
Title Compound ◽  
Inversion Symmetry ◽  
Asymmetric Unit ◽  
Methyl Substituent ◽  
Torsion Angles ◽  
Pyrazine Ring ◽  
Compound C ◽  
Sodium Methanethiolate

The title compound, C12H20N2S4, synthesized by the reaction of 2,3,5,6-tetrakis(bromomethyl)pyrazine with sodium methanethiolate, crystallizes with a half -molecule in the asymmetric unit. The whole molecule is generated by inversion symmetry; the inversion centre being located in the centre of the pyrazine ring. The molecule has an S-shaped conformation with two (methylsulfanyl)methyl substituent arms directed above the plane of the pyrazine ring and two below. The C(H3)—S—C(H2)—C(aromatic) torsion angles are 70.47 (18) and −67.65 (17)°, respectively. In the crystal, molecules are linkedviaweak C—H...S hydrogen bonds, forming chains along [001] and enclosingR22(12) ring motifs. The chains are linked by further weak C—H...S hydrogen bonds, forming sheets lying parallel to (101).

A New Approach to Imidazo[1,5-a]indole Derivatives

2000 ◽  
Vol 65 (7) ◽  
pp. 1163-1172 ◽  
Author(s):  
Peter Kutschy ◽  
Mojmír Suchý ◽  
Milan Dzurilla ◽  
Mitsuo Takasugi ◽  
Vladimír Kováčik
Keyword(s):  
Antifungal Activity ◽  
Methyl Iodide ◽  
Potassium Carbonate ◽  
Lithium Hydride ◽  
Indole Derivatives ◽  
New Approach ◽  
Methyl Derivatives ◽  
Nucleophilic Reagents ◽  
Sodium Methanethiolate ◽  
Derivatives Of

Reaction of indole-2-carbonyl isothiocyanate (1) with sodium methanethiolate afforded 1-thioxo-1H-imidazo[1,5-a]indol-3(2H)-one (3). Its methylation with methyl iodide in the presence of lithium hydride in dimethylformamide, or potassium carbonate in acetone resulted in the formation of corresponding S- and N-methyl derivatives 4 and 5. N-(Indole-2-carbonyl)thiocarbamates and N-(indole-2-carbonyl)thioureas prepared by treatment of isothiocyanate 1 with corresponding nucleophilic reagents were S-methylated with methyl iodide in acetone in the presence of potassium carbonate. The obtained N-(indole- 2-carbonyl) substituted thiocarbonimidates 15, 16 and isothioureas 17-20 afforded by treatment with lithium hydride in dimethylformamide the derivatives of imidazo[1,5-a]- indol-3-one 23-28 in 49-87% yields. Antifungal activity of the prepared compounds has been examined, using the fungus Bipolaris leersiae. 1-Methylsulfanyl-3H-imidazo-[1,5-a]- indol-3-one (4) exhibited the highest antifungal activity.

Thioxanthene derivatives with neurotropic activity; synthesis of 9-(3-dimethylaminopropylidene)-2-(methylthiomethyl)thioxanthene and of some related compounds

1984 ◽  
Vol 49 (7) ◽  
pp. 1722-1730 ◽  
Author(s):  
Vojtěch Kmoníček ◽  
Václav Bártl ◽  
Miroslav Protiva
Keyword(s):  
Sulfuric Acid ◽  
Title Compound ◽  
Neurotropic Activity ◽  
Tertiary Alcohol ◽  
Dilute Sulfuric Acid ◽  
Acid Catalyzed ◽  
Sodium Methanethiolate ◽  
Related Compounds

A reaction of 2-(bromomethyl)thioxanthone with sodium methanethiolate with sodium methanethiolate gave 2-(methylthiomethyl)thioxanthone (II) which was transformed by treatment with 3-dimethylaminopropylmagnesium chloride to the tertiary alcohol IV. Its dehydration by heating with dilute sulfuric acid afforded the title compound I. An attempt at preparing the analogous 2-(methoxymethyl) derivative proceeded similarly but failed in the stage of the acid-catalyzed dehydration of the tertiary alcohol V. Acids VIII-XII and the nitrile XIII were prepared as potential intermediates. Compound I has properties of a tranquilizer with a weak cataleptic activity.

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