Model for the aspartate proteinases. Hydrolysis of a distorted amide catalyzed by dicarboxylic acids capable of forming cyclic anhydrides

1988 ◽  
Vol 110 (8) ◽  
pp. 2625-2629 ◽  
Author(s):  
V. Somayaji ◽  
Jeff. Keillor ◽  
R. S. Brown
Keyword(s):  
Dicarboxylic Acids ◽  
Cyclic Anhydrides ◽  
Hydrolysis Of

Oligomeric stannoxanes

1968 ◽  
Vol 46 (14) ◽  
pp. 2409-2413 ◽  
Author(s):  
Shmuel Migdal ◽  
David Gertner ◽  
Albert Zilkha
Keyword(s):  
Dicarboxylic Acids ◽  
Molar Ratio ◽  
Sodium Salts ◽  
Interfacial Conditions ◽  
Organotin Polyesters ◽  
Basic Hydrolysis ◽  
Hydrolysis Of

The controlled basic hydrolysis of tetrabutyl-1,3-dichlorodistannoxane under interfacial conditions was found to lead to α,ω-dichlorooligostannoxanes, Cl(SnBu2O)nSnBu2Cl, n being controlled by the molar ratio of base to distannoxane. These oligostannoxanes were identical with those prepared by other methods. They were used in the preparation of oligostannoxane dicarboxylates and organotin polyesters, having stannoxane recurring units in their backbone, by reaction with the sodium salts of mono- or dicarboxylic acids under interfacial conditions.

Hydrolytic products of 4-aryl-2,3-dicyano-1-naphthol derivatives

1981 ◽  
Vol 46 (9) ◽  
pp. 2207-2216 ◽  
Author(s):  
Jiří Křepelka ◽  
Iva Vančurová ◽  
Jiří Holubek ◽  
Jiří Roubík
Keyword(s):  
Dicarboxylic Acids ◽  
Ring Closure ◽  
Partial Hydrolysis ◽  
H Nmr ◽  
Antiviral Effects ◽  
Hydrolysis Of ◽  
Derivatives Of ◽  
Naphthol Derivatives ◽  
Intramolecular Ring

Depending on the conditions of hydrolysis, vicinal aromatic dicyano derivatives Ia-Ic gave anhydrides IIa-IIe and imides of 4-aryl-1-alkoxynaphthalene-2,3-dicarboxylic acids, IIIa,b, along with products of partial hydrolysis, decarboxylation and demethylation, IVa-IVd, IVf-IVg, and derivatives of benzo(c)fluorene, Va-Vc. The derivatives Va-Vc were also obtained by acid hydrolysis of dicyano derivatives Id-Ig. Methanolysis of the anhydride IId gave a mixture of positional isomers, IVh, which was esterified to the diester IVe. Intramolecular ring closure of the isomers IVh afforded derivatives of benzo(c)fluorene, VIa-VIb. The structures of the selected compounds were corroborated by IR and 1H NMR spectra. The compounds Va-Vc exhibited antiviral effects and interferonogenic activities in vivo.

ChemInform Abstract: Reactions of Cyclic Anhydrides. Part 21. Carbon-Carbon Coupling on Attempted Hydrolysis of Bromomaleimides.

ChemInform ◽  
2010 ◽  
Vol 23 (1) ◽  
pp. no-no
Author(s):  
V. BALASUBRAMANIYAN ◽  
G. K. LADDHA ◽  
N. P. ARGADE
Keyword(s):  
Cyclic Anhydrides ◽  
Hydrolysis Of

Facile and Efficient Synthesis of Cyclic Anhydrides from Dicarboxylic Acids

ACS Catalysis ◽  
2014 ◽  
Vol 4 (10) ◽  
pp. 3586-3589 ◽  
Author(s):  
Carine Robert ◽  
Frédéric de Montigny ◽  
Christophe M. Thomas
Keyword(s):  
Dicarboxylic Acids ◽  
Efficient Synthesis ◽  
Cyclic Anhydrides

scholarly journals (2R,3R)-1,4-Dioxaspiro[4.4]nonane-2,3-dicarboxylic and (2R,3R)-1,4-dioxaspiro[4.5]decane-2,3-dicarboxylic acids

2018 ◽  
Vol 74 (8) ◽  
pp. 1058-1062
Author(s):  
Mikhail E. Minyaev ◽  
Dmitrii M. Roitershtein ◽  
Alexey A. Vinogradov ◽  
Ivan V. Ananyev ◽  
Ilya E. Nifant'ev
Keyword(s):  
Hydrogen Bonds ◽  
Ethyl Acetate ◽  
Single Crystals ◽  
Crystal Structures ◽  
Single Molecule ◽  
Dicarboxylic Acids ◽  
Two Dimensional ◽  
Asymmetric Unit ◽  
Hydrolysis Of

The title compounds, C9H12O6 and C10H14O6, were formed by careful hydrolysis of the corresponding diethyl esters. Their single crystals were grown from an ethyl acetate/hexane mixture. Crystals of both compounds have monoclinic (P21) symmetry with a single molecule in the asymmetric unit. Both crystal structures are very similar and display four –CO—OH...O=C(OH)– hydrogen bonds, forming a two-dimensional double-layered framework.

scholarly journals Studies on Cyclic Anhydrides. IV. Rate Constants for the Hydrolysis of Some Cyclic Anhydrides Exhibiting Ring Strain.

1972 ◽  
Vol 26 ◽  
pp. 239-249 ◽  
Author(s):  
L. Eberson ◽  
L. Landström ◽  
Per-Olof Kinell ◽  
Jean Galy ◽  
W. B. Pearson ◽  
...  
Keyword(s):  
Rate Constants ◽  
Ring Strain ◽  
Cyclic Anhydrides ◽  
Hydrolysis Of

2,2-Dimethylsuccinic acid derivatives in isoprenoid synthesis: a 2,2-dimethylvinyl anion equivalent in the synthesis of ar-atlantone, ar-turmerone, and prenylated aromatic compounds

1992 ◽  
Vol 70 (5) ◽  
pp. 1317-1322 ◽  
Author(s):  
George M. Strunz ◽  
Li Ya
Keyword(s):  
Aromatic Compounds ◽  
Dicarboxylic Acids ◽  
Lead Tetraacetate ◽  
Keto Acid ◽  
Acid Catalyzed ◽  
Crotonyl Chloride ◽  
Hydrolysis Of

The anion of methyl 2,2-dimethylsuccinate was alkylated with benzylic bromides to give the corresponding 3-substituted-2,2-dimethylsuccinates. Hydrolysis to the dicarboxylic acids, followed by bisdecarboxylation with lead tetraacetate, afforded 1-aryl-3-methyl-2-butenes, which are model prenylated aromatic compounds. Acylation of methyl 2,2-dimethylsuccinate with E-3-(4′-methylphenyl) crotonyl chloride gave the substituted succinate 9. Hydrolysis of the ester groups and acid-catalyzed decarboxylation of the resulting β-ketoacid produced the keto acid 10, which was decarboxylated by the Kochi method, furnishing ar-atlantone. Hydrogenation of 10 yielded 12, which on similar decarboxylation afforded ar-turmerone.

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