Activation of amide nitrogen-hydrogen bonds by iron and ruthenium phosphine complexes

1990 ◽  
Vol 112 (4) ◽  
pp. 1628-1629 ◽  
Author(s):  
David R. Schaad ◽  
Clark R. Landis
Keyword(s):  
Hydrogen Bonds ◽  
Amide Nitrogen ◽  
Phosphine Complexes ◽  
Nitrogen Hydrogen Bonds

scholarly journals Crystal structure of atazanavir, C38H52N6O7

2020 ◽  
Vol 35 (2) ◽  
pp. 129-135
Author(s):  
James A. Kaduk ◽  
Amy M. Gindhart ◽  
Thomas N. Blanton
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bonds ◽  
Powder Diffraction ◽  
Density Functional ◽  
Carbonyl Oxygen ◽  
Hydroxyl Group ◽  
Amide Nitrogen ◽  
Classical Hydrogen Bond ◽  
Intramolecular Hydrogen ◽  
Atazanavir Sulfate

The crystal structure of atazanavir has been solved and refined using synchrotron X-ray powder diffraction data and optimized using density functional techniques. Atazanavir crystallizes in space group P21 (#4) with a = 15.33545(7), b = 5.90396(3), c = 21.56949(13) Å, β = 96.2923(4)°, V = 1941.134(11) Å3, and Z = 2. Despite being labeled as “atazanavir sulfate”, the commercial reagent sample consisted of atazanavir free base. The structure consists of an array of extended-conformation molecules parallel to the ac-plane. Although the atazanavir molecule contains only four classical hydrogen bond donors, hydrogen bonding is, surprisingly, important to the crystal energy. Both intra- and intermolecular hydrogen bonds are significant. The hydroxyl group forms bifurcated intramolecular hydrogen bonds to a carbonyl oxygen atom and an amide nitrogen. Several amide nitrogens act as donors to the hydroxyl group and carbonyl oxygen atoms. An amide nitrogen acts as a donor to another amide nitrogen. Several methyl, methylene, methyne, and phenyl hydrogens participate in hydrogen bonds to carbonyl oxygens, an amide nitrogen, and the pyridine nitrogen. The powder pattern is included in the Powder Diffraction File™ as entry 00-065-1426.

Cleavage of Nitrogen–Hydrogen Bonds of Ammonia Induced by Triruthenium Polyhydrido Clusters

2006 ◽  
Vol 45 (6) ◽  
pp. 950-952 ◽  
Author(s):  
Yumiko Nakajima ◽  
Hajime Kameo ◽  
Hiroharu Suzuki
Keyword(s):  
Hydrogen Bonds ◽  
Nitrogen Hydrogen Bonds
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