Combined use of stereospecific deuteration, NMR, distance geometry, and energy minimization for the conformational analysis of the highly .delta. opioid receptor selective peptide [D-Pen2,D-Pen5]enkephalin

1990 ◽  
Vol 112 (2) ◽  
pp. 822-829 ◽  
Author(s):  
Henry I. Mosberg ◽  
Katarzyna Sobczyk-Kojiro ◽  
Pullachipatti Subramanian ◽  
Gordon M. Crippen ◽  
Kondareddiar Ramalingam ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Opioid Receptor ◽  
Energy Minimization ◽  
Distance Geometry ◽  
Delta Opioid Receptor ◽  
Combined Use

scholarly journals Combined use of NMR, distance geometry, and restrained energy minimization for the conformational analysis of 8-lysine–vasopressin

1992 ◽  
Vol 70 (7) ◽  
pp. 1950-1955 ◽  
Author(s):  
Chin Yu ◽  
Ta-Horng Yang ◽  
Chao-Jung Yeh ◽  
Li-Chin Chuang
Keyword(s):  
Conformational Analysis ◽  
Energy Minimization ◽  
Distance Geometry ◽  
2D Nmr ◽  
Membered Ring ◽  
Dmso Solution ◽  
Tail Region ◽  
Lysine Vasopressin ◽  
Combined Use ◽  
Neurohypophyseal Hormone

The conformation of the neurohypophyseal hormone, 8-lysine–vasopressin, in DMSO solution has been determined from 2D-NMR and distance geometry followed by the restrained energy minimization calculation. The conformation of 8-lysin–vasopressin in the 20-membered ring region is well defined but the acyclic tripeptide tail region is disordered.

Levels of Delta-Opioid Receptor mRNA in Morphine-Tolerant Mice

Analgesia ◽  
1995 ◽  
Vol 1 (3) ◽  
pp. 195-200 ◽  
Author(s):  
Benjamin Kest ◽  
Shirzad Jenab ◽  
Charles E. Inturrisi
Keyword(s):  
Opioid Receptor ◽  
Delta Opioid Receptor ◽  
Receptor Mrna

scholarly journals A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding.

1993 ◽  
Vol 268 (31) ◽  
pp. 23055-23058
Author(s):  
H Kong ◽  
K Raynor ◽  
K Yasuda ◽  
S.T. Moe ◽  
P.S. Portoghese ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Opioid Receptor ◽  
Delta Opioid Receptor ◽  
Agonist Binding ◽  
High Affinity
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