Probing the structural determinants of a catalytic RNA with isomerase activity

1995 ◽  
Vol 117 (40) ◽  
pp. 10145-10146 ◽  
Author(s):  
James R. Prudent ◽  
Joanna Staunton ◽  
Peter G. Schultz
Keyword(s):  
Catalytic Rna ◽  
Structural Determinants ◽  
Isomerase Activity

Induction of Endothelial Tissue Factor by Endotoxin and Its Precursors

1993 ◽  
Vol 70 (04) ◽  
pp. 702-706 ◽  
Author(s):  
Charles F Moldow ◽  
Ronald R Bach ◽  
Katherine Staskus ◽  
Paul D Rick
Keyword(s):  
Tissue Factor ◽  
Lipid A ◽  
Umbilical Vein ◽  
Structural Determinants ◽  
Monophosphoryl Lipid A ◽  
Maximal Induction ◽  
Umbilical Vein Endothelial Cells ◽  
Acyloxyacyl Hydrolase ◽  
Endothelial Tissue ◽  
Specific Mrna

SummaryThe structural determinants of lipopolysaccharide required for the induction of tissue factor in human umbilical vein endothelial cells were studied. Intact lipid A was essential for the induction of tissue factor whereas the incomplete lipid A precursors lipid IVA and lipid X, as well as monophosphoryl lipid A and acyloxyacyl hydrolase-treated lipopolysaccharide, were unable to induce tissue factor and tissue factor specific mRNA. However, the lipid A precursor, lipid IVA, was able to inhibit LPS-mediated induction of tissue factor; structural determinants distal to lipid A were found to be required for maximal induction of tissue factor activity and tissue factor mRNA. The presence of serum in the assay was found to amplify but was not obligate for tissue factor induction by LPS.

Structural Determinants of Homelessness in the United States

1991 ◽  
Vol 38 (1) ◽  
pp. 113-131 ◽  
Author(s):  
Marta Elliott ◽  
Lauren J. Krivo
Keyword(s):  
United States ◽  
The United States ◽  
Structural Determinants

Social Justice and Dietetic Education: Are We Preparing Practitioners to Lead?

2020 ◽  
Vol 81 (3) ◽  
pp. 120-126
Author(s):  
Jennifer Brady
Keyword(s):  
Social Justice ◽  
Education And Training ◽  
Determinants Of Health ◽  
Structural Determinants ◽  
Social Justice Advocacy ◽  
Dietetic Education ◽  
Qualitative Survey ◽  
The Social ◽  
Reflexive Practice ◽  
And Training

Purpose: To explore dietetic practitioners’ perceptions of their education and training in the knowledge, skills, and confidence to understand social justice issues and to engage in socially just dietetic practice and social justice advocacy. Methods: An online semi-qualitative survey sent to Canadian dietitians. Results: Most respondents (n = 264; 81.5%) felt that knowledge- and skill-based learning about social justice and social justice advocacy should be a part of dietetic education and training. Reasons given by respondents for the importance of social justice learning include: client-centred care and reflexive practice, effecting change to the social and structural determinants of health, preventing dietitian burnout, and relevance of the profession. Yet, over half of respondents either strongly disagreed or disagreed that they were adequately prepared with the knowledge (n = 186; 57.4%), skills (n = 195; 60.2%), or confidence (n = 196; 60.5%) to engage in advocacy related to social justice concerns. Some questioned the practicality of adding social justice learning via additional courses to already full programs, while others proposed infusing a social justice lens across dietetic education and practice areas. Conclusions: Dietetic education and training must do more to prepare dietitians to answer calls for dietitians to engage in social justice issues through practice and advocacy.

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