Catalytic Antibodies in Organic Synthesis. Asymmetric Synthesis of (-)-.alpha.-Multistriatin

1995 ◽  
Vol 117 (12) ◽  
pp. 3653-3654 ◽  
Author(s):  
Subhash C. Sinha ◽  
Ehud Keinan
Keyword(s):  
Asymmetric Synthesis ◽  
Organic Synthesis ◽  
Catalytic Antibodies

scholarly journals Asymmetric Synthesis of Quinine: A Landmark in Organic Synthesis

2006 ◽  
Vol 1 (10) ◽  
pp. 1934578X0600101 ◽  
Author(s):  
Vijay Nair ◽  
Rajeev S. Menon ◽  
Sreekumar Vellalath
Keyword(s):  
Organic Chemistry ◽  
Total Synthesis ◽  
Asymmetric Synthesis ◽  
Organic Synthesis ◽  
Chemical Industry ◽  
Crucial Role ◽  
Historical Perspective ◽  
Modern Medicine ◽  
Present Review ◽  
Catalytic Asymmetric Synthesis

Ever since its isolation in 1820, Quinine has played a crucial role in the development of organic chemistry, the chemical industry and modern medicine. A total synthesis of quinine, widely regarded as an event of epochal importance, was claimed by Woodward and Doering in 1945. This work, however, heavily relied on unsubstantiated literature reports and it appears that Woodward's work fell short of a total synthesis of quinine. The first total synthesis of quinine was reported by Uskokovic in the 1970s. The first stereoselective total synthesis of quinine was accomplished only in 2001, by Stork, who incidentally is the originator of the concept of stereoselectivity in total synthesis. Apart from the stereoselectivity, Stork's synthesis of quinine is remarkable for its conceptual uniqueness and retrosynthetic novelty. Naturally, this work has been attested as a landmark in organic synthesis by leaders in the field. Subsequently, Jacobson and Kobayashi reported the catalytic asymmetric synthesis of quinine in 2003 and 2004, respectively. Both these synthesis have followed a similar approach. The present review has attempted to provide a concise account of the synthesis of quinine from a historical perspective.

A Different Approach to Enantioselective Organic Synthesis: Absolute Asymmetric Synthesis of Organometallic Reagents

2009 ◽  
Vol 121 (17) ◽  
pp. 3183-3186 ◽  
Author(s):  
Anders Lennartson ◽  
Susanne Olsson ◽  
Jonas Sundberg ◽  
Mikael Håkansson
Keyword(s):  
Asymmetric Synthesis ◽  
Organic Synthesis ◽  
Organometallic Reagents ◽  
Absolute Asymmetric Synthesis

scholarly journals Recent Advances in Organocatalyzed Asymmetric Synthesis of Benzopyran and Benzodihydropyran (Chromane) Nuclei

Symmetry ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1510
Author(s):  
Renato Dalpozzo ◽  
Raffaella Mancuso
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
Organic Synthesis ◽  
Building Blocks ◽  
Core Structure ◽  
The Core ◽  
Recent Advances ◽  
Set Up

Benzopyran and benzodihydropyran (chromane) nuclei are the core structure of many natural products, in particular flavonoids. Many compounds possessing this structure are nutraceuticals, pharmaceutical nutrients. Therefore, benzopyran and chromane scaffolds are important building blocks in organic synthesis and many efforts have been made to set up efficient methods for their synthesis. In particular, asymmetric methods are of great importance, being natural products, and generally chiral substances. This review aims to cover literature in the range 2017–first half of 2019.

Bidentate Lewis acid catalysts in asymmetric synthesis

2002 ◽  
Vol 74 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Keiji Maruoka
Keyword(s):  
Asymmetric Synthesis ◽  
Organic Synthesis ◽  
Lewis Acid ◽  
Lewis Acids ◽  
Asymmetric Induction ◽  
Acid Catalysts ◽  
Lewis Acid Catalysts ◽  
High Chemical ◽  
Bidentate Lewis Acids

The chemistry of bidentate Lewis acids belongs to an unexplored field of science, and so far has been only poorly studied. This paper illustrates the design of several bidentate Al and Ti Lewis acids, and their successful application to selective organic synthesis, particularly to asymmetric synthesis. For example, a new, chiral bidentate Ti(IV) complex is successfully designed by adding commercially available Ti(OPri)4 and (S)-binaphthol sequentially to 2,2'-bis(tritylamino)-4,4'-dichlorobenzophenone in CH2Cl2, and can be utilized for simultaneous coordination to aldehyde carbonyls, thereby allowing the precise enantioface discrimination of such carbonyls for a new catalytic, practical enantioselective allylation of aldehydes with allyltributyltin. This chiral bidentate Ti(IV) catalyst exhibits uniformly high asymmetric induction as well as high chemical yields for various aldehydes. The present enantioselective allylation is highly chemoselective in the presence of other carbonyl moieties.

scholarly journals Asymmetric Organic Synthesis with Catalytic Antibodies.

1996 ◽  
Vol 50 ◽  
pp. 679-687 ◽  
Author(s):  
Ehud Keinan ◽  
Subhash C. Sinha ◽  
Doron Shabat ◽  
Harel Itzhaky ◽  
Jean-Louis Reymond ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Catalytic Antibodies
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