Crystal structure of HIV-1 protease in complex with VX-478, a potent and orally bioavailable inhibitor of the enzyme

1995 ◽  
Vol 117 (3) ◽  
pp. 1181-1182 ◽  
Author(s):  
E. E. Kim ◽  
C. T. Baker ◽  
M. D. Dwyer ◽  
M. A. Murcko ◽  
B. G. Rao ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Orally Bioavailable ◽  
Hiv 1

An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease:  Computational Analysis and X-ray Crystal Structure of the Enzyme Complex

1997 ◽  
Vol 40 (16) ◽  
pp. 2440-2444 ◽  
Author(s):  
Amos B. Smith ◽  
Ralph Hirschmann ◽  
Alexander Pasternak ◽  
Wenquing Yao ◽  
Paul A. Sprengeler ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Computational Analysis ◽  
Enzyme Complex ◽  
X Ray ◽  
Orally Bioavailable ◽  
Hiv 1

scholarly journals Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450

1996 ◽  
Vol 3 (4) ◽  
pp. 301-314 ◽  
Author(s):  
C. Nicholas Hodge ◽  
Paul E. Aldrich ◽  
Lee T. Bacheler ◽  
Chong-Hwan Chang ◽  
Charles J. Eyermann ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Human Pharmacokinetics ◽  
Resistance Profile ◽  
X Ray ◽  
Hiv 1

Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action

2010 ◽  
Vol 122 (10) ◽  
pp. 1849-1852 ◽  
Author(s):  
Séverine Freisz ◽  
Guillaume Bec ◽  
Marco Radi ◽  
Philippe Wolff ◽  
Emmanuele Crespan ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Reverse Transcriptase ◽  
Mechanism Of Action ◽  
Hiv 1

Crystal Structure of the Broadly Cross-Reactive HIV-1-Neutralizing Fab X5 and Fine Mapping of Its Epitope†,‡

Biochemistry ◽  
2004 ◽  
Vol 43 (6) ◽  
pp. 1410-1417 ◽  
Author(s):  
Ramalakshmi Darbha ◽  
Sanjay Phogat ◽  
Aran F. Labrijn ◽  
Yuuei Shu ◽  
Yijun Gu ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Fine Mapping ◽  
Hiv 1

scholarly journals Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein

2008 ◽  
Vol 6 (11) ◽  
pp. 2297-2307 ◽  
Author(s):  
Felix F. Vajdos ◽  
Sanghee Yoo ◽  
Megan Houseweart ◽  
Wesley I. Sundquist ◽  
Christopher P. Hill
Keyword(s):  
Crystal Structure ◽  
Binding Site ◽  
Capsid Protein ◽  
Cyclophilin A ◽  
Hiv 1
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