Short Enantioselective Synthesis of (-)-Ovalicin, a Potent Inhibitor of Angiogenesis, Using Substrate-Enhanced Catalytic Asymmetric Dihydroxylation

1994 ◽  
Vol 116 (26) ◽  
pp. 12109-12110 ◽  
Author(s):  
E. J. Corey ◽  
Angel Guzman-Perez ◽  
Mark C. Noe
Keyword(s):  
Potent Inhibitor ◽  
Enantioselective Synthesis ◽  
Asymmetric Dihydroxylation ◽  
Catalytic Asymmetric

Enantioselective synthesis of 20(S)-camptothecin using sharpless catalytic asymmetric dihydroxylation

1995 ◽  
Vol 6 (6) ◽  
pp. 1245-1248 ◽  
Author(s):  
Sang-sup Jew ◽  
Kwang-dae Ok ◽  
Hee-jin Kim ◽  
Myoung Goo Kim ◽  
Jong Min Kim ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Asymmetric Dihydroxylation ◽  
Catalytic Asymmetric

Total Synthesis of Camptothecins: An Update

Synlett ◽  
2017 ◽  
Vol 28 (10) ◽  
pp. 1134-1150 ◽  
Author(s):  
Fen-Er Chen ◽  
Lei Chen
Keyword(s):  
Total Synthesis ◽  
Stereoselective Synthesis ◽  
Enantioselective Synthesis ◽  
The Novel ◽  
Asymmetric Dihydroxylation ◽  
New Methods ◽  
Considerable Research ◽  
Catalytic Asymmetric ◽  
Synthetic Approaches ◽  
Asymmetric Hydroxylation

Over the last few decades, considerable research efforts have been directed toward the development of effective chemical syntheses of camptothecin and its analogs. The last comprehensive review of this area was published in 2003 and many effective new methods have since been reported for the stereoselective synthesis of the camptothecin alkaloids. In this account, we have summarized most of the novel synthetic approaches developed for the synthesis of camptothecins during the last decade. We have focused on strategies for the construction of the pentacyclic ring system and the different methods used to install the chiral quaternary center on the E ring of camptothecin.1 Introduction2 Synthesis of Racemic Camptothecins3 Enantioselective Synthesis of Camptothecins3.1 Sharpless Asymmetric Dihydroxylation3.2 Catalytic Asymmetric Cyanosilylation3.3 Auxiliary-Induced Asymmetric Carbonyl Addition3.4 Catalytic Asymmetric Ethylation3.5 Asymmetric Hydroxylation4 Conclusion

Enantioselective Synthesis of Eucomols Using Sharpless Catalytic Asymmetric Dihydroxylation

Heterocycles ◽  
1997 ◽  
Vol 46 (1) ◽  
pp. 65 ◽  
Author(s):  
Sang-sup Jew ◽  
Hyun-ah Kim ◽  
Jeong-hoon Kim ◽  
Hyeung-geun Park
Keyword(s):  
Enantioselective Synthesis ◽  
Asymmetric Dihydroxylation ◽  
Catalytic Asymmetric

ChemInform Abstract: Catalytic Asymmetric Dihydroxylation of Olefins with New Catalysts: The First Example of Heterogenization of OsO42- by Ion-Exchange Technique.

ChemInform ◽  
2010 ◽  
Vol 33 (4) ◽  
pp. no-no
Author(s):  
Boyapati M. Choudary ◽  
Naidu S. Chowdari ◽  
Mannepalli L. Kantam ◽  
Kondapuram V. Raghavan
Keyword(s):  
Ion Exchange ◽  
Asymmetric Dihydroxylation ◽  
Catalytic Asymmetric ◽  
Exchange Technique

scholarly journals Enantioselective synthesis of (−)-chloramphenicol via silver-catalysed asymmetric isocyanoacetate aldol reaction

2016 ◽  
Vol 14 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Allegra Franchino ◽  
Pavol Jakubec ◽  
Darren J. Dixon
Keyword(s):  
Aldol Reaction ◽  
Enantioselective Synthesis ◽  
Asymmetric Aldol ◽  
Asymmetric Aldol Reaction ◽  
Catalytic Asymmetric

A concise synthesis of (−)-chloramphenicol, based on the catalytic asymmetric aldol reaction between 4-nitrobenzaldehyde and benzhydryl isocyanoacetate, is reported.

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