Total Synthesis of Aplyronine A, a Potent Antitumor Substance of Marine Origin

1994 ◽  
Vol 116 (16) ◽  
pp. 7443-7444 ◽  
Author(s):  
Hideo Kigoshi ◽  
Makoto Ojika ◽  
Takeshi Ishigaki ◽  
Kiyotake Suenaga ◽  
Tsuyoshi Mutou ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Marine Origin ◽  
Aplyronine A

Aplyronine A, a Potent Antitumor Substance of Marine Origin, Aplyronines B and C, and Artificial Analogues:  Total Synthesis and Structure−Cytotoxicity Relationships

1996 ◽  
Vol 61 (16) ◽  
pp. 5326-5351 ◽  
Author(s):  
Hideo Kigoshi ◽  
Kiyotake Suenaga ◽  
Tsuyoshi Mutou ◽  
Takeshi Ishigaki ◽  
Toshiyuki Atsumi ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Marine Origin ◽  
Aplyronine A

ChemInform Abstract: Total Synthesis of Aplyronine A (I), a Potent Antitumor Substance of Marine Origin.

ChemInform ◽  
2010 ◽  
Vol 26 (15) ◽  
pp. no-no
Author(s):  
H. KIGOSHI ◽  
M. OJIKA ◽  
T. ISHIGAKI ◽  
K. SUENAGA ◽  
T. MUTOU ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Marine Origin ◽  
Aplyronine A

Cytotoxicity and actin-depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and its analogs

Tetrahedron ◽  
2002 ◽  
Vol 58 (6) ◽  
pp. 1075-1102 ◽  
Author(s):  
Hideo Kigoshi ◽  
Kiyotake Suenaga ◽  
Masaki Takagi ◽  
Atsushi Akao ◽  
Kengo Kanematsu ◽  
...  
Keyword(s):  
Marine Origin ◽  
Aplyronine A

Aplyronine A, a potent antitumor macrolide of marine origin, and the congeners aplyronines B and C: isolation, structures, and bioactivities

Tetrahedron ◽  
2007 ◽  
Vol 63 (15) ◽  
pp. 3138-3167 ◽  
Author(s):  
Makoto Ojika ◽  
Hideo Kigoshi ◽  
Yoshifumi Yoshida ◽  
Takeshi Ishigaki ◽  
Masanori Nisiwaki ◽  
...  
Keyword(s):  
Marine Origin ◽  
Aplyronine A

Total Synthesis of Biselide A, A Cytotoxic Macrolide of Marine Origin

Synthesis ◽  
2017 ◽  
Vol 49 (13) ◽  
pp. 2958-2970 ◽  
Author(s):  
Ichiro Hayakawa ◽  
Hideo Kigoshi ◽  
Masami Okamura ◽  
Kazuaki Suzuki ◽  
Mami Shimanuki ◽  
...  
Keyword(s):  
Enzymatic Hydrolysis ◽  
Total Synthesis ◽  
Functional Group ◽  
Aldol Reaction ◽  
Oxygen Functional Group ◽  
Asymmetric Aldol ◽  
Marine Origin ◽  
Asymmetric Aldol Reaction ◽  
Cytotoxic Macrolide

The total synthesis of biselide A based on our earlier strategy of synthesizing haterumalides is reported. The highlights of this approach are the use of regioselective enzymatic hydrolysis for the installation of a C20 oxygen functional group and an asymmetric aldol reaction for the stereoselective introduction of a C3 oxygen functional group.

Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B–H: chemistry and biology

2009 ◽  
Vol 26 (1) ◽  
pp. 27-43 ◽  
Author(s):  
Kiyoyuki Yamada ◽  
Makoto Ojika ◽  
Hideo Kigoshi ◽  
Kiyotake Suenaga
Keyword(s):  
Marine Origin ◽  
Aplyronine A
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