Enhanced Oxygen Diffusion through a Porous Membrane Chemically Modified with Cobalt Porphyrin on Its Pore Surface

1994 ◽  
Vol 116 (10) ◽  
pp. 4503-4504 ◽  
Author(s):  
Hiroyuki Nishide ◽  
Takayuki Suzuki ◽  
Ryuji Nakagawa ◽  
Eishun Tsuchida
1995 ◽  
Vol 99 (32) ◽  
pp. 12312-12317 ◽  
Author(s):  
Hiroyuki Nishide ◽  
Takayuki Suzuki ◽  
Ryuji Nakagawa ◽  
Keita Itakura ◽  
Eishun Tsuchida

1988 ◽  
Vol 92 (22) ◽  
pp. 6461-6464 ◽  
Author(s):  
Eishun Tsuchida ◽  
Hiroyuki Nishide ◽  
Manshi Ohyanagi ◽  
Osamu Okada

MEMBRANE ◽  
2010 ◽  
Vol 35 (2) ◽  
pp. 86-92 ◽  
Author(s):  
Shinya Matsuno ◽  
Akio Iwanade ◽  
Daisuke Umeno ◽  
Kyoichi Saito ◽  
Hajime Ito ◽  
...  

1991 ◽  
Vol 24 (23) ◽  
pp. 6306-6309 ◽  
Author(s):  
Hiroyuki Nishide ◽  
Hiroyoshi Kawakami ◽  
Takayuki Suzuki ◽  
Yasutaka Azechi ◽  
Yuji Soejima ◽  
...  

Langmuir ◽  
1998 ◽  
Vol 14 (25) ◽  
pp. 7112-7118 ◽  
Author(s):  
Toshihiko Jimbo ◽  
Akihiko Tanioka ◽  
Norihiko Minoura

Author(s):  
R.L. Sabatini ◽  
Yimei Zhu ◽  
Masaki Suenaga ◽  
A.R. Moodenbaugh

Low temperature annealing (<400°C) of YBa2Cu3O7x in a ozone containing oxygen atmosphere is sometimes carried out to oxygenate oxygen deficient thin films. Also, this technique can be used to fully oxygenate thinned TEM specimens when oxygen depletion in thin regions is suspected. However, the effects on the microstructure nor the extent of oxygenation of specimens has not been documented for specimens exposed to an ozone atmosphere. A particular concern is the fact that the ozone gas is so reactive and the oxygen diffusion rate at these temperatures is so slow that it may damage the specimen by an over-reaction. Thus we report here the results of an investigation on the microstructural effects of exposing a thinned YBa2Cu3O7-x specimen in an ozone atmosphere using transmission electron microscopy and energy loss spectroscopy techniques.


1989 ◽  
Vol 61 (01) ◽  
pp. 131-136 ◽  
Author(s):  
Richard A Harvey ◽  
Hugh C Kim ◽  
Jonathan Pincus ◽  
Stanley Z Trooskin ◽  
Josiah N Wilcox ◽  
...  

SummaryTissue plasminogen activator labeled with radioactive iodine (125I-tPA) was immobilized on vascular prostheses chemically modified with a thin coating of water-insoluble surfactant, tridodecylmethylammonium chloride (TDM AC). Surfactant- treated Dacron, polytetrafluoroethylene (PTFE), silastic, polyethylene and polyurethane bound appreciable amounts of 125I- tPA (5-30 μg 125I-tPA/cm2). Upon exposure to human plasma, the amount of 125I-tPA bound to the surface shows an initial drop during the first hour of incubation, followed by a slower, roughly exponential release with a t½ of appoximately 75 hours. Prostheses containing bound tPA show fibrinolytic activity as measured both by lysis of clots formed in vitro, and by hydrolysis of a synthetic polypeptide substrate. Prior to incubation in plasma, tPA bound to a polymer surface has an enzymic activity similar, if not identical to that of the native enzyme in buffered solution. However, exposure to plasma causes a decrease in the fibrinolytic activity of both bound tPA and enzyme released from the surface of the polymer. These data demonstrate that surfactant-treated prostheses can bind tPA, and that these chemically modified devices can act as a slow-release drug delivery system with the potential for reducing prosthesis-induced thromboembolism.


Sign in / Sign up

Export Citation Format

Share Document