Chemical Probe for Glycosidic Conformation in Telomeric DNAs

1994 ◽  
Vol 116 (10) ◽  
pp. 4479-4480 ◽  
Author(s):  
Eric Dias ◽  
John L. Battiste ◽  
James R. Williamson
Keyword(s):  
Chemical Probe ◽  
Glycosidic Conformation

SGC-CK2-1: The First Selective Chemical Probe for the Pleiotropic Kinase CK2

2020 ◽  
Author(s):  
Carrow Wells ◽  
David Drewry ◽  
Julie E. Pickett ◽  
Alison D. Axtman
Keyword(s):  
Cell Lines ◽  
Small Molecule ◽  
Chemical Probe ◽  
High Quality ◽  
Extensive Evaluation ◽  
Key Driver ◽  
Selective Chemical ◽  
Kinase Ck2 ◽  
Ck2 Inhibitors

Building upon a wealth of published knowledge surrounding the pyrazolopyrimidine scaffold, we designed a small library around the most selective small molecule CK2 inhibitors reported. Through extensive evaluation of this library we identified inhibitor 24 (SGC-CK2-1) as a potent, selective, and cell-active CK2 chemical probe. Remarkably, despite years of research pointing to CK2 as a key driver in cancer, our probe did not elicit an antiproliferative phenotype in cell lines tested. While many publications have attempted tocharacterize CK2 function, CK2 biology is complex and a high-quality chemical tool like SGC-CK2-1 will aid in connecting CK2 functions to phenotypes.

Bevel Structure Based XPS Analysis as a Non‐Destructive Chemical Probe for Complex Interfacial Structures of Organic Semiconductors

Small Methods ◽  
2021 ◽  
pp. 2001264
Author(s):  
Dong‐Jin Yun ◽  
Seunghyup Lee ◽  
Seong Heon Kim ◽  
Changhoon Jung ◽  
Yong Su Kim ◽  
...  
Keyword(s):  
Organic Semiconductors ◽  
Xps Analysis ◽  
Chemical Probe ◽  
Interfacial Structures ◽  
Non Destructive

A macrophage uptaking near-infrared chemical probe CDnir7 for in vivo imaging of inflammation

2014 ◽  
Vol 50 (50) ◽  
pp. 6589 ◽  
Author(s):  
Nam-Young Kang ◽  
Sung-Jin Park ◽  
Xiao Wei Emmiline Ang ◽  
Animesh Samanta ◽  
Wouter H. P. Driessen ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Near Infrared ◽  
Chemical Probe

A dual-function chemical probe for detecting erasers of lysine lipoylation

2021 ◽  
Author(s):  
Yusheng Xie ◽  
Jie Zhang ◽  
Liu Yang ◽  
Qingxin Chen ◽  
Quan Hao ◽  
...  
Keyword(s):  
Dual Function ◽  
Chemical Probe
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