Quantitative evidence for the mechanism of RNA cleavage by enzyme mimics. Cleavage and isomerization of UpU by morpholine buffers

1993 ◽  
Vol 115 (23) ◽  
pp. 10705-10713 ◽  
Author(s):  
Ronald Breslow ◽  
Ruo Xu
Keyword(s):  
Rna Cleavage ◽  
Enzyme Mimics ◽  
Quantitative Evidence

Living Same-Name Siblings and British Historical Demography

2011 ◽  
pp. 15-36 ◽  
Author(s):  
Chris Galley ◽  
Eilidh Garrett ◽  
Ros Davies ◽  
Alice Reid
Keyword(s):  
Nineteenth Century ◽  
Eighteenth Century ◽  
Historical Demography ◽  
Vital Registration ◽  
Regional Variations ◽  
Quantitative Evidence ◽  
Registration Data ◽  
Vital Registration Data ◽  
The Rich ◽  
Isle Of Skye

This article examines the extent to which living siblings were given identical first names. Whilst the practice of sibling name-sharing appeared to have died out in England during the eighteenth century, in northern Scotland it persisted at least until the end of the nineteenth century. Previously it has not been possible to provide quantitative evidence of this phenomenon, but an analysis of the rich census and vital registration data for the Isle of Skye reveals that this practice was widespread, with over a third of eligible families recording same-name siblings. Our results suggest that further research should focus on regional variations in sibling name-sharing and the extent to which this northern pattern occurred in other parts of Britain.

Numbers

2017 ◽  
Author(s):  
Mark Edele
Keyword(s):  
Second World War ◽  
Prisoners Of War ◽  
World War ◽  
Quantitative Evidence ◽  
Methodological Problems ◽  
Second World

How many Soviet soldiers defected to the Germans? Vague statements abound in the literature, but few scholars have tried to systematically investigate the available quantitative evidence. This chapter discusses the available numbers on defectors from both Soviet and German sources. It discusses the methodological problems involved in establishing the total number and the share of defectors among Soviet prisoners of war (POWs). It also compares these numbers with comparative cases in other fronts of the Second World War in Europe. It shows that despite methodological and source problems we can be confident that defection was much more prevalent at the German–Soviet front than elsewhere.

Doubtful Readers

2020 ◽  
Author(s):  
Erin A. McCarthy
Keyword(s):  
William Shakespeare ◽  
Early Modern ◽  
English Literature ◽  
John Donne ◽  
Early Modern England ◽  
Aemilia Lanyer ◽  
Quantitative Evidence ◽  
Early Modern Poetry ◽  
Literary Histories ◽  
Over Time

Doubtful Readers: Print, Poetry, and the Reading Public in Early Modern England focuses on early modern publishers’ efforts to identify and accommodate new readers of verse that had previously been restricted to particular social networks in manuscript. Focusing on the period between the maturing of the market for printed English literature in the 1590s and the emergence of the professional poet following the Restoration, this study shows that poetry was shaped by—and itself shaped—strong print publication traditions. By reading printed editions of poems by William Shakespeare, Aemilia Lanyer, John Donne, and others, this book shows how publishers negotiated genre, gender, social access, reputation, literary knowledge, and the value of English literature itself. It uses literary, historical, bibliographical, and quantitative evidence to show how publishers’ strategies changed over time. Ultimately, Doubtful Readers argues that although—or perhaps because—publishers’ interpretive and editorial efforts are often elided in studies of early modern poetry, their interventions have had an enduring impact on our canons, texts, and literary histories.

scholarly journals Role of efficient testing and contact tracing in mitigating the COVID-19 pandemic: a network modelling study

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e045886
Author(s):  
Yiying Hu ◽  
Jianying Guo ◽  
Guanqiao Li ◽  
Xi Lu ◽  
Xiang Li ◽  
...  
Keyword(s):  
Real World ◽  
Case Fatality ◽  
Contact Tracing ◽  
Secondary Outcome ◽  
Time Interval ◽  
Fatality Rate ◽  
Real World Data ◽  
Network Modelling ◽  
World Data ◽  
Quantitative Evidence

ObjectivesThis study quantified how the efficiency of testing and contact tracing impacts the spread of COVID-19. The average time interval between infection and quarantine, whether asymptomatic cases are tested or not, and initial delays to beginning a testing and tracing programme were investigated.SettingWe developed a novel individual-level network model, called CoTECT (Testing Efficiency and Contact Tracing model for COVID-19), using key parameters from recent studies to quantify the impacts of testing and tracing efficiency. The model distinguishes infection from confirmation by integrating a ‘T’ compartment, which represents infections confirmed by testing and quarantine. The compartments of presymptomatic (E), asymptomatic (I), symptomatic (Is), and death with (F) or without (f) test confirmation were also included in the model. Three scenarios were evaluated in a closed population of 3000 individuals to mimic community-level dynamics. Real-world data from four Nordic countries were also analysed.Primary and secondary outcome measuresSimulation result: total/peak daily infections and confirmed cases, total deaths (confirmed/unconfirmed by testing), fatalities and the case fatality rate. Real-world analysis: confirmed cases and deaths per million people.Results(1) Shortening the duration between Is and T from 12 to 4 days reduces infections by 85.2% and deaths by 88.8%. (2) Testing and tracing regardless of symptoms reduce infections by 35.7% and deaths by 46.2% compared with testing only symptomatic cases. (3) Reducing the delay to implementing a testing and tracing programme from 50 to 10 days reduces infections by 35.2% and deaths by 44.6%. These results were robust to sensitivity analysis. An analysis of real-world data showed that tests per case early in the pandemic are critical for reducing confirmed cases and the fatality rate.ConclusionsReducing testing delays will help to contain outbreaks. These results provide policymakers with quantitative evidence of efficiency as a critical value in developing testing and contact tracing strategies.

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