Active site dynamics of xylene hydroxylation by cytochrome P-450 as revealed by kinetic deuterium isotope effects

Robert P. Hanzlik; Kah Hiing John Ling

doi:10.1021/ja00074a001

Active site dynamics of xylene hydroxylation by cytochrome P-450 as revealed by kinetic deuterium isotope effects

Journal of the American Chemical Society ◽

10.1021/ja00074a001 ◽

1993 ◽

Vol 115 (21) ◽

pp. 9363-9370 ◽

Cited By ~ 34

Author(s):

Robert P. Hanzlik ◽

Kah Hiing John Ling

Keyword(s):

Active Site ◽

Isotope Effects ◽

Deuterium Isotope Effects ◽

Cytochrome P 450

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Deuterium isotope effects on toluene metabolism. Product release as a rate-limiting step in cytochrome P-450 catalysis

Biochemical and Biophysical Research Communications ◽

10.1016/0006-291x(89)92511-4 ◽

1989 ◽

Vol 160 (2) ◽

pp. 844-849 ◽

Cited By ~ 34

Author(s):

Kah-Hiing John Ling ◽

Robert P. Hanzlik

Keyword(s):

Isotope Effects ◽

Product Release ◽

Rate Limiting Step ◽

Limiting Step ◽

Deuterium Isotope Effects ◽

Rate Limiting ◽

Cytochrome P 450

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Secondary deuterium isotope effects on olefin epoxidation by cytochrome P-450

Biochemical Pharmacology ◽

10.1016/0006-2952(78)90099-0 ◽

1978 ◽

Vol 27 (10) ◽

pp. 1441-1444 ◽

Cited By ~ 30

Author(s):

Robert P. Hanzlik ◽

Greg O. Shearer

Keyword(s):

Isotope Effects ◽

Olefin Epoxidation ◽

Deuterium Isotope Effects ◽

Cytochrome P 450

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ChemInform Abstract: Regioselectivity and Deuterium Isotope Effects in Geraniol Hydroxylation by the Cytochrome P-450 Monooxygenase from Catharanthus roseus (L.) G. Don.

ChemInform ◽

10.1002/chin.198716144 ◽

1987 ◽

Vol 18 (16) ◽

Author(s):

H. FRETZ ◽

W.-D. WOGGON

Keyword(s):

Catharanthus Roseus ◽

Isotope Effects ◽

Deuterium Isotope Effects ◽

Cytochrome P 450

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Inter- and intramolecular deuterium isotope effects on the cytochrome P-450-catalyzed oxidative dehalogenation of 1,1,2,2-tetrachloroethane

Biochemical and Biophysical Research Communications ◽

10.1016/0006-291x(87)90369-x ◽

1987 ◽

Vol 149 (2) ◽

pp. 319-325 ◽

Cited By ~ 8

Author(s):

Dale B. Hales ◽

Bert Ho ◽

John A. Thompson

Keyword(s):

Isotope Effects ◽

Deuterium Isotope Effects ◽

Cytochrome P 450

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Inhibitor Binding to the Binuclear Active Site of Tyrosinase: Temperature, pH, and Solvent Deuterium Isotope Effects

Biochemistry ◽

10.1021/bi00185a010 ◽

1994 ◽

Vol 33 (19) ◽

pp. 5739-5744 ◽

Cited By ~ 38

Author(s):

Jennifer S. Conrad ◽

Sharon R. Dawso ◽

Esmine R. Hubbard ◽

Theresa E. Meyers ◽

Kenneth G. Strothkamp

Keyword(s):

Active Site ◽

Isotope Effects ◽

Inhibitor Binding ◽

Deuterium Isotope Effects

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Kinetic deuterium isotope effects on the N-demethylation of tertiary amides by cytochrome P-450.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)38353-x ◽

1990 ◽

Vol 265 (21) ◽

pp. 12349-12355

Author(s):

L R Hall ◽

R P Hanzlik

Keyword(s):

Isotope Effects ◽

Deuterium Isotope Effects ◽

Tertiary Amides ◽

Cytochrome P 450

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Studies of the catalytic mechanism of an active-site mutant (Y14F) of .DELTA.5-3-ketosteroid isomerase by kinetic deuterium isotope effects

Biochemistry ◽

10.1021/bi00109a008 ◽

1991 ◽

Vol 30 (45) ◽

pp. 10858-10865 ◽

Cited By ~ 26

Author(s):

Liang Xue ◽

Paul Talalay ◽

Albert S. Mildvan

Keyword(s):

Active Site ◽

Catalytic Mechanism ◽

Isotope Effects ◽

Ketosteroid Isomerase ◽

Deuterium Isotope Effects

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Kinetic isotope effects in cytochrome P-450-catalyzed oxidation reactions. Intermolecular and intramolecular deuterium isotope effects during the N-demethylation of N,N-dimethylphentermine.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)43699-x ◽

1980 ◽

Vol 255 (13) ◽

pp. 6049-6054 ◽

Cited By ~ 3

Author(s):

G.T. Miwa ◽

W.A. Garland ◽

B.J. Hodshon ◽

A.Y. Lu ◽

D.B. Northrop

Keyword(s):

Isotope Effects ◽

Kinetic Isotope Effects ◽

Oxidation Reactions ◽

Kinetic Isotope ◽

Deuterium Isotope Effects ◽

Cytochrome P 450 ◽

Catalyzed Oxidation

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Insights into deuterium isotope effects on the metabolism of steroid hormones and foreign compounds by cytochrome P-450 enzymes

Life Sciences ◽

10.1016/0024-3205(91)90573-t ◽

1991 ◽

Vol 49 (1) ◽

pp. 1-14 ◽

Cited By ~ 5

Author(s):

James R. Gillette

Keyword(s):

Steroid Hormones ◽

Isotope Effects ◽

Deuterium Isotope Effects ◽

Cytochrome P 450

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Regioselectivity and Deuterium Isotope Effects in Geraniol Hydroxylation by the Cytochrome P-450 Monooxygenase fromCatharanthus roseus (L.) G. DON

Helvetica Chimica Acta ◽

10.1002/hlca.19860690822 ◽

1986 ◽

Vol 69 (8) ◽

pp. 1959-1970 ◽

Cited By ~ 18

Author(s):

Heinz Fretz ◽

Wolf-Dietrich Woggon

Keyword(s):

Isotope Effects ◽

Deuterium Isotope Effects ◽

Cytochrome P 450

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