Minor Groove Hydration Is Critical to the Stability of DNA Duplexes

2000 ◽  
Vol 122 (27) ◽  
pp. 6512-6513 ◽  
Author(s):  
Tao Lan ◽  
Larry W. McLaughlin
Keyword(s):  
Minor Groove ◽  
Dna Duplexes ◽  
The Stability

Importance of minor groove functional groups for the stability of DNA duplexes

Biopolymers ◽  
2002 ◽  
Vol 65 (3) ◽  
pp. 211-217 ◽  
Author(s):  
Zhenhua Sun ◽  
Dongli Chen ◽  
Tao Lan ◽  
Larry W. McLaughlin
Keyword(s):  
Functional Groups ◽  
Minor Groove ◽  
Dna Duplexes ◽  
The Stability

Stabilization of G•C-Containing DNA Duplexes by Polyamides with Parallel Orientation in the Minor Groove

2004 ◽  
Vol 30 (5) ◽  
pp. 502-504
Author(s):  
A. N. Sinyakov ◽  
A. S. Boutorine ◽  
C. Héléne ◽  
V. A. Ryabinin
Keyword(s):  
Minor Groove ◽  
Dna Duplexes ◽  
Parallel Orientation

Molecular Dynamics and Continuum Solvent Studies of the Stability of PolyG-PolyC and PolyA-PolyT DNA Duplexes in Solution

1998 ◽  
Vol 16 (2) ◽  
pp. 265-280 ◽  
Author(s):  
Thomas E. Cheatham ◽  
Jayashree Srinivasan ◽  
David A. Case ◽  
Peter A. Kollman
Keyword(s):  
Molecular Dynamics ◽  
Dna Duplexes ◽  
The Stability

scholarly journals Rapid assessment of the stability of DNA duplexes by impedimetric real-time monitoring of chemically induced denaturation

Lab on a Chip ◽  
2011 ◽  
Vol 11 (9) ◽  
pp. 1656 ◽  
Author(s):  
B. van Grinsven ◽  
N. Vanden Bon ◽  
L. Grieten ◽  
M. Murib ◽  
S. D. Janssens ◽  
...  
Keyword(s):  
Real Time ◽  
Rapid Assessment ◽  
Dna Duplexes ◽  
Real Time Monitoring ◽  
Chemically Induced ◽  
The Stability

Influence of dangling thymidine residues on the stability and structure of two DNA duplexes

Biochemistry ◽  
1988 ◽  
Vol 27 (10) ◽  
pp. 3879-3885 ◽  
Author(s):  
Mary Senior ◽  
Roger A. Jones ◽  
Kenneth J. Breslauer
Keyword(s):  
Dna Duplexes ◽  
The Stability

Novel aspects of the structure of the Escherichia coli nucleoid investigated by a rapid sedimentation assay

1982 ◽  
Vol 60 (10) ◽  
pp. 952-961 ◽  
Author(s):  
Jeremy S. Lee ◽  
A. Richard Morgan
Keyword(s):  
Escherichia Coli ◽  
Gamma Irradiation ◽  
Protein Interactions ◽  
The State ◽  
Condensed State ◽  
Dna Duplexes ◽  
Rna Triplex ◽  
Negative Supercoiling ◽  
The Stability ◽  
Dna Protein Interactions

The Escherichia coli nucleoid is maintained in its folded highly condensed state by constraints which involve RNA and protein. We have developed a rapid sedimentation assay to determine the state of folding of the membrane-free nucleoid. An approximate measure of the stability of the nucleoids under various conditions can then be estimated by measuring the temperature at which the nucleoids unfold. Using ethidium and gamma irradiation (which removes the negative supercoiling of the native nucleoid) as probes, it can be shown that there are two types of constraint involved in the condensation of the nucleoid. One of these constraints is destablized by ethidium but stabilized by negative supercoiling; the second constraint is unaffected by both ethidium and negative supercoiling. Several models can be proposed: (i) a DNA∙RNA duplex, (ii) a double-strand DNA (dsDNA)∙RNA triplex, (iii) DNA-protein interactions, (iv) a topological knot with RNA, and (v) a DNA tetraplex. The topological knot model is not consistent with the data and many combinations of the others can be excluded. If RNA is involved in both constraints then RNA∙DNA duplexes and dsDNA∙RNA triplexes are involved in stabilizing the nucleoid.

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