Convergent functional groups. 13. High-affinity complexation of adenosine derivatives within induced binding pockets

1993 ◽  
Vol 115 (9) ◽  
pp. 3548-3557 ◽  
Author(s):  
M. Morgan Conn ◽  
Ghislain Deslongchamps ◽  
Javier de Mendoza ◽  
Julius Rebek
Keyword(s):  
Functional Groups ◽  
High Affinity ◽  
Binding Pockets ◽  
Adenosine Derivatives

scholarly journals N6-Cycloalkyl- andN6-Bicycloalkyl-C5′(C2′)-modified Adenosine Derivatives as High-Affinity and Selective Agonists at the Human A1Adenosine Receptor with Antinociceptive Effects in Mice

2009 ◽  
Vol 52 (10) ◽  
pp. 3430-3430 ◽  
Author(s):  
Palmarisa Franchetti ◽  
Loredana Cappellacci ◽  
Patrizia Vita ◽  
Riccardo Petrelli ◽  
Antonio Lavecchia ◽  
...  
Keyword(s):  
High Affinity ◽  
Antinociceptive Effects ◽  
Adenosine Derivatives ◽  
Selective Agonists

Involvement of nitrogen functional groups in high-affinity copper binding in tomato and wheat root apoplasts: spectroscopic and thermodynamic evidence

Metallomics ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 366-376 ◽  
Author(s):  
Stéphanie Guigues ◽  
Matthieu N. Bravin ◽  
Cédric Garnier ◽  
Armand Masion ◽  
Claire Chevassus-Rosset ◽  
...  
Keyword(s):  
Functional Groups ◽  
Local Environment ◽  
Wheat Root ◽  
Copper Binding ◽  
High Affinity

A dual local environment of Cu in root apoplasts was identified.

scholarly journals Agarose Hydrogels Enriched by Humic Acids as the Complexation Agent

Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 687 ◽  
Author(s):  
Martina Klučáková
Keyword(s):  
Methylene Blue ◽  
Humic Substances ◽  
Functional Groups ◽  
Humic Acids ◽  
Diffusion Coefficients ◽  
Rhodamine 6G ◽  
Effective Diffusion ◽  
High Affinity ◽  
Effective Diffusion Coefficients ◽  
Complexation Agent

The transport properties of agarose hydrogels enriched by humic acids were studied. Methylene blue, rhodamine 6G and Cu(II) ions were incorporated into hydrogel as diffusion probes, and then their release into water was monitored. Cu(II) ions as well as both the dyes studied in this work have high affinity to humic substances and their interactions strongly affected their diffusion in hydrogels. It was confirmed that humic acids retarded the transport of diffusion probes. Humic acids’ enrichment caused the decrease in the values of effective diffusion coefficients due to their complexation with diffusion probes. In general, the diffusion of dyes was more affected by the complexation with humic acids in comparison with Cu(II) ions. The effect of complexation was selective for the particular diffusion probe. The strongest effect was obtained for the diffusion of methylene blue. It was assumed that metal ions interacted preferentially with acidic functional groups. In contrast to Cu(II) ions, dyes can interact with acidic functional groups, and the condensed cyclic structures of the dye probes supported their interactions with the hydrophobic domains of humic substances.

2-Pyrazolyl-N6-Substituted Adenosine Derivatives as High Affinity and Selective Adenosine A3Receptor Agonists

2004 ◽  
Vol 47 (19) ◽  
pp. 4766-4773 ◽  
Author(s):  
Elfatih Elzein ◽  
Venkata Palle ◽  
Yuzhi Wu ◽  
Tenning Maa ◽  
Dewan Zeng ◽  
...  
Keyword(s):  
High Affinity ◽  
Adenosine Derivatives

scholarly journals PGM-Free ORR Catalysts Designed by Templating PANI-Type Polymers Containing Functional Groups with High Affinity to Iron

2019 ◽  
Vol 166 (7) ◽  
pp. F3240-F3245 ◽  
Author(s):  
Xi Yin ◽  
Hoon T. Chung ◽  
Ulises Martinez ◽  
Ling Lin ◽  
Kateryna Artyushkova ◽  
...  
Keyword(s):  
Functional Groups ◽  
High Affinity

N6-Cycloalkyl- andN6-Bicycloalkyl-C5′(C2′)-modified Adenosine Derivatives as High-Affinity and Selective Agonists at the Human A1Adenosine Receptor with Antinociceptive Effects in Mice

2009 ◽  
Vol 52 (8) ◽  
pp. 2393-2406 ◽  
Author(s):  
Palmarisa Franchetti ◽  
Loredana Cappellacci ◽  
Patrizia Vita ◽  
Riccardo Petrelli ◽  
Antonio Lavecchia ◽  
...  
Keyword(s):  
High Affinity ◽  
Antinociceptive Effects ◽  
Adenosine Derivatives ◽  
Selective Agonists

Synthesis and applications of functionalized silsesquioxane polymers attached to organic and inorganic matrices

2008 ◽  
Vol 80 (7) ◽  
pp. 1593-1611 ◽  
Author(s):  
Yoshitaka Gushikem ◽  
Edilson V. Benvenutti ◽  
Yuriy V. Kholin
Keyword(s):  
Functional Groups ◽  
Metal Ion ◽  
Adsorption Process ◽  
Electrochemical Sensors ◽  
Water Soluble ◽  
Soluble Form ◽  
High Affinity ◽  
Insoluble Form ◽  
Amine Groups ◽  
Electroactive Species

Organofunctionalized silsesquioxane polymers obtained in a water-soluble form can be used to coat various substrates such as SiO2, SiO2/Al2O3, Al2O3, cellulose/Al2O3, and graphite or, when obtained in a water-insoluble form, can be used directly. These organofunctionalized silsesquioxanes can also be attached to poly(dimethylsiloxane) (PDMS) polymers. The functional groups constituted by neutral amine groups or cationic groups (pyridinium, 3- and 4-picolinium, or 1,4-diazabicyclo[2.2.2]octane (DABCO), mono- or -dicationic) have relatively high affinity for metal ion in ethanol solutions, as shown by their stability constants. Materials containing attached cationic functional groups have also been efficiently used to immobilize various electroactive species and to construct electrochemical sensors for analytical applications. This work discusses the preparation of silsesquioxane derivatives, their characterization as prepared and when dispersed on several substrates, and comments on some applications of these materials, with an emphasis on the metal adsorption process and manufacture of electrochemical sensors.

scholarly journals Structure of a lectin from the sea musselCrenomytilus grayanus(CGL)

2015 ◽  
Vol 71 (11) ◽  
pp. 1429-1436 ◽  
Author(s):  
Michał Jakób ◽  
Jacek Lubkowski ◽  
Barry R. O'Keefe ◽  
Alexander Wlodawer
Keyword(s):  
Crystal Structure ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
Cancer Cells ◽  
Sequence Homology ◽  
Structural Comparison ◽  
High Affinity ◽  
Significant Interest ◽  
Binding Pockets ◽  
Antiviral Activities

CGL is a 150 amino-acid residue lectin that was originally isolated from the sea musselCrenomytilus grayanus. It is specific for binding GalNAc/Gal-containing carbohydrate moieties and in general does not share sequence homology with other known galectins or lectins. Since CGL displays antibacterial, antifungal and antiviral activities, and interacts with high affinity with mucin-type receptors, which are abundant on some cancer cells, knowledge of its structure is of significant interest. Conditions have been established for the expression, purification and crystallization of a recombinant variant of CGL. The crystal structure of recombinant CGL was determined and refined at a resolution of 2.12 Å. The amino-acid sequence of CGL contains three homologous regions (73% similarity) and the folded protein has a β-trefoil topology. Structural comparison of CGL with the closely related lectin MytiLec allowed description of the glycan-binding pockets.

Sign in / Sign up

Export Citation Format

Share Document