Observation of tightly bound boron-11 nuclear magnetic resonance signals on serine proteases. Direct solution evidence for tetrahedral geometry around the boron in the putative transition-state analogs

1991 ◽  
Vol 113 (25) ◽  
pp. 9429-9435 ◽  
Author(s):  
Sheng Zhong ◽  
Frank Jordan ◽  
Charles Kettner ◽  
Laszlo Polgar
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Transition State ◽  
Serine Proteases ◽  
Direct Solution ◽  
Tetrahedral Geometry ◽  
Transition State Analogs ◽  
Nuclear Magnetic

scholarly journals Phosphorus nuclear-magnetic-resonance studies of a transition-state analogue complex of creatine kinase

1977 ◽  
Vol 167 (3) ◽  
pp. 827-829 ◽  
Author(s):  
E J Milner-White ◽  
D S Rycroft
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Creatine Kinase ◽  
Magnetic Resonance ◽  
Transition State ◽  
Magnetic Resonance Studies ◽  
High Affinity ◽  
Transition State Analogue ◽  
Nuclear Magnetic Resonance Spectra ◽  
High Affinity Site ◽  
Nuclear Magnetic

31P nuclear-magnetic-resonance spectra of MgADP bound to creatine kinase in the presence of creatine NO3- ions show that there are two non-identical forms of the bound nucleotide. The sites have different affinities for the nucleotide. MgADP at the high-affinity site is in slow exchange (k less than 125s-1 at 27 degrees C) with free MgADP.

Nuclear magnetic resonance and neutron diffraction studies of the complex of ribonuclease A with uridine vanadate, a transition-state analog

Biochemistry ◽  
1985 ◽  
Vol 24 (8) ◽  
pp. 2058-2067 ◽  
Author(s):  
Babul Borah ◽  
Chi Wan Chen ◽  
William Egan ◽  
Maria Miller ◽  
Alexander Wlodawer ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Neutron Diffraction ◽  
Transition State ◽  
Ribonuclease A ◽  
Transition State Analog ◽  
Nuclear Magnetic

Orientation of azide addition to homoconjugated dienes

1970 ◽  
Vol 48 (2) ◽  
pp. 345-350 ◽  
Author(s):  
R. S. McDaniel ◽  
A. C. Oehlschlager
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Double Bond ◽  
Magnetic Resonance ◽  
Transition State ◽  
Phenyl Azide ◽  
Nuclear Magnetic Resonance Spectra ◽  
Bicyclic Dienes ◽  
Magnetic Resonance Spectra ◽  
Nuclear Magnetic

The 1,3-dipolarcycloaddition of phenyl azide to bicyclic dienes 8–10 proceeds readily at the angle strained double bond to give both 1,2,3-Δ2-triazoline isomers which would result from the two possible orientations of addition. The major triazoline isomer in each case is that resulting from stabilization of the dipolar transition state by the neighboring unreactive double bond. The structures of the triazolines were deduced from their nuclear magnetic resonance spectra in CCl4, CDCl3, and C6H6.

An emerging technology: Nuclear magnetic resonance microscopy

1988 ◽  
Vol 46 ◽  
pp. 1000-1001
Author(s):  
M.J. Hennessy ◽  
E. Kwok
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Relaxation Times ◽  
Basic Research ◽  
Local Environment ◽  
Magnetic Resonance Images ◽  
Nmr Microscopy ◽  
Mri Scans ◽  
Temperature Relaxation ◽  
Nuclear Magnetic

Much progress in nuclear magnetic resonance microscope has been made in the last few years as a result of improved instrumentation and techniques being made available through basic research in magnetic resonance imaging (MRI) technologies for medicine. Nuclear magnetic resonance (NMR) was first observed in the hydrogen nucleus in water by Bloch, Purcell and Pound over 40 years ago. Today, in medicine, virtually all commercial MRI scans are made of water bound in tissue. This is also true for NMR microscopy, which has focussed mainly on biological applications. The reason water is the favored molecule for NMR is because water is,the most abundant molecule in biology. It is also the most NMR sensitive having the largest nuclear magnetic moment and having reasonable room temperature relaxation times (from 10 ms to 3 sec). The contrast seen in magnetic resonance images is due mostly to distribution of water relaxation times in sample which are extremely sensitive to the local environment.

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