Interaction of bis(platinum) complexes with the mononucleotide 5'-guanosine monophosphate. Effect of diamine linker and the nature of the bis(platinum) complex on product formation

1991 ◽  
Vol 113 (13) ◽  
pp. 4851-4857 ◽  
Author(s):  
Yun Qu ◽  
Nicholas Farrell
Keyword(s):  
Platinum Complex ◽  
Platinum Complexes ◽  
Product Formation ◽  
Guanosine Monophosphate

Bildung wasserlöslicher Histidin-Platin- Komplexe aus metallischem Platin und Histidin / Formation of Water Soluble Histidine Platinum Complexes from Metallic Platinum and Histidine

1988 ◽  
Vol 43 (4) ◽  
pp. 499-500 ◽  
Author(s):  
Eva Ehrenstorfer-Schäfers ◽  
Helmut Hartl ◽  
Wolfgang Beck
Keyword(s):  
Atomic Absorption ◽  
Absorption Spectroscopy ◽  
Atomic Absorption Spectroscopy ◽  
Platinum Complex ◽  
Platinum Complexes ◽  
Water Soluble ◽  
Oxygen Atmosphere ◽  
Metallic Platinum

AbstractMetallic Platinum dissolves under oxygen atmosphere in aqueous histidine solution. About 0.1 to 0.3 μmol of a water soluble histidine platinum complex per ml solution have been found by atomic absorption spectroscopy.

scholarly journals Synthesis, Characterization and Cytotoxic Activity of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide and Its Pt(II) Complex

2019 ◽  
pp. 1-12
Author(s):  
Nasser Mohammed Hosny ◽  
Lamiaa A. A. Barakat
Keyword(s):  
Cytotoxic Activity ◽  
Anthranilic Acid ◽  
Platinum Complex ◽  
Platinum Complexes ◽  
Ehrlich Ascites Carcinoma ◽  
Morphological Characterization ◽  
Spherical Particles ◽  
Spectral Techniques ◽  
Average Size

Since the discovery of the platinum based complex, cisplatin, medicinal inorganic chemistry has attracted much more attention and a large number of platinum complexes with promising pharmacological properties have been synthesized. In this work a new platinum complex of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide (HL) has been synthesized and characterized by physical and spectral techniques, as elemental analysis, IR, EI-MS, 1H-NMR, thermal analysis, transmittance electron microscope (TEM) and magnetic moment. The results indicated that the ligand binds to Pt(II) in the enol form. Square-planar stereochemistry was suggested for the Pt(II) complex. The morphological characterization showed nano-sized spherical particles with average size 92 nm of the isolated complex. The synthesized Pt(II) complex exhibited a significant cytotoxic activity against HCT116 and HEPG2. Also in vivo study of the Pt(II) complex showed cytotoxic activity towards Ehrlich ascites carcinoma (EAC).

scholarly journals Characterization of platinum(II) complexes exhibiting inhibitory activity against the 20S proteasome

2020 ◽  
Vol 7 (8) ◽  
pp. 200545
Author(s):  
Tatsuto Kiwada ◽  
Hiromu Katakasu ◽  
Serina Okumura ◽  
Akira Odani
Keyword(s):  
Inhibitory Activity ◽  
Chemical Structure ◽  
Competitive Inhibition ◽  
Proteasome Inhibitors ◽  
Platinum Complex ◽  
Platinum Complexes ◽  
Binding Mode ◽  
Structure Activity Relationships ◽  
Structure Activity

Proteasome inhibitors are useful for biochemical research and clinical treatment. In our previous study, we reported that the 4N-coordinated platinum complexes with anthracenyl ring and heterocycle exhibited proteasome-inhibitory activity. In the present study, the structure–activity relationships and characterization of these complexes were determined for the elucidation of the role of aromatic ligands. Lineweaver–Burk analysis revealed that the chemical structure of heterocycles affects the binding mode of platinum complexes. Platinum complexes with anthracenyl ring and pyridine showed competitive inhibition, although platinum complexes with anthracenyl ring and phenanthroline showed non-competitive inhibition. The structure–activity relationships demonstrated that anthracenyl moiety plays a crucial role in proteasome-inhibitory activity. The platinum complexes with naphthyl or phenyl rings exhibited lower inhibitory activities than the platinum complex with anthracenyl ring. The reactivity with N-acetylcysteine varied according to the chemical structure of complexes.

Molecular isomeric engineering of naphthyl-quinoline-containing dinuclear platinum complexes to tune emission from deep red to near infrared

2019 ◽  
Vol 7 (3) ◽  
pp. 630-638 ◽  
Author(s):  
Wenjing Xiong ◽  
Fanyuan Meng ◽  
Caifa You ◽  
Pu Wang ◽  
Junting Yu ◽  
...  
Keyword(s):  
Near Infrared ◽  
Platinum Complex ◽  
Platinum Complexes ◽  
Dinuclear Platinum ◽  
Dinuclear Platinum Complex ◽  
Dinuclear Platinum Complexes ◽  
Tunable Emission

A type of isomeric dinuclear platinum complex of (C^N)2Pt2(μ-C8PhOXT)2 is synthesized with different C^N isomers of naphthyl-quinoline. These complexes exhibit tunable emission with different emissive efficiencies.

scholarly journals Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes

2018 ◽  
Vol 5 (2) ◽  
pp. 171340 ◽  
Author(s):  
Marcelo Echeverri ◽  
Amparo Alvarez-Valdés ◽  
Francisco Navas ◽  
Josefina Perles ◽  
Isabel Sánchez-Pérez ◽  
...  
Keyword(s):  
Single Crystal ◽  
Platinum Complex ◽  
Platinum Complexes ◽  
Phosphine Ligands ◽  
Biological Role ◽  
Biological Models ◽  
X Ray Diffraction ◽  
X Ray ◽  
Calf Thymus ◽  
The Stability

Three platinum complexes with cis and trans configuration cis -[Pt(TCEP) 2 Cl 2 ], cis -[Pt(tmTCEP) 2 Cl 2 ] and trans -[Pt(TCEP) 2 Cl 2 ], where TCEP is tris(2-carboxyethyl)phosphine, have been synthesized and fully characterized by usual techniques including single-crystal X-ray diffraction for trans -[Pt(TCEP) 2 Cl 2 ] and cis -[Pt(tmTCEP) 2 Cl 2 ]. Here, we also report on an esterification process of TCEP, which takes place in the presence of alcohols, leading to a platinum complex coordinated to an ester tmTCEP (2-methoxycarbonylethyl phosphine) ligand. The stability in solution of the three compounds and their interaction with biological models such as DNA (pBR322 and calf thymus DNA) and proteins (lysozyme and RNase) have also been studied.

scholarly journals N-Heterocyclic Carbene-Platinum Complexes Featuring an Anthracenyl Moiety: Anti-Cancer Activity and DNA Interaction

2019 ◽  
Vol 20 (17) ◽  
pp. 4198 ◽  
Author(s):  
Sébastien Harlepp ◽  
Edith Chardon ◽  
Mathilde Bouché ◽  
Georges Dahm ◽  
Mounir Maaloum ◽  
...  
Keyword(s):  
Optical Tweezers ◽  
Platinum Complex ◽  
Platinum Complexes ◽  
Dna Interaction ◽  
Contour Length ◽  
State Behavior ◽  
Force Microscopy ◽  
Pt Complex ◽  
Dna Strands

A platinum (II) complex stabilized by a pyridine and an N-heterocyclic carbene ligand featuring an anthracenyl moiety was prepared. The compound was fully characterized and its molecular structure was determined by single-crystal X-ray diffraction. The compound demonstrated high in vitro antiproliferative activities against cancer cell lines with IC50 ranging from 10 to 80 nM. The presence of the anthracenyl moiety on the N-heterocyclic carbene (NHC) Pt complex was used as a luminescent tag to probe the metal interaction with the nucleobases of the DNA through a pyridine-nucleobase ligand exchange. Such interaction of the platinum complex with DNA was corroborated by optical tweezers techniques and liquid phase atomic force microscopy (AFM). The results revealed a two-state interaction between the platinum complex and the DNA strands. This two-state behavior was quantified from the different experiments due to contour length variations. At 24 h incubation, the stretching curves revealed multiple structural breakages, and AFM imaging revealed a highly compact and dense structure of platinum complexes bridging the DNA strands.

Preparation of Pt/activated carbon and Pt/alumina catalysts by impregnation with platinum complexes

1983 ◽  
Vol 48 (2) ◽  
pp. 517-526 ◽  
Author(s):  
Vladimír Machek ◽  
Vlastimil Růžička ◽  
Marie Šourková ◽  
Jiří Kunz ◽  
Leoš Janáček
Keyword(s):  
Activated Carbon ◽  
Liquid Phase ◽  
Platinum Complex ◽  
Platinum Complexes ◽  
Nonuniform Distribution ◽  
Platinum Compound ◽  
Chloroplatinic Acid ◽  
Platinum Compounds ◽  
Adsorption Rates ◽  
Alumina Catalysts

Activated carbon and alumina catalysts were prepared by impregnation with solutions of platinum compounds differing substantially in the nature of their interaction with the supports: chloroplatinic acid (dissolved in water or acetone), tetraammineplatinum dichloride, and tetrakis (triphenylphosphine)platinum complex. The relations between the course of impregnation, distribution of platinum across the catalyst grain, and the activity of the catalyst in liquid phase hydrogenations were studied. Lower adsorption rates and amounts of the platinum compound adsorbed on the support bring about a more uniform platinum distribution across the grain. Catalysts with a uniform distribution exhibit higher activities than those with nonuniform distribution. The highest activity was achieved with Pt/alumina catalysts prepared from triphenylphosphine platinum comlex thermally treated in oxygen atmosphere prior to the reduction.

scholarly journals Heterogeneous hydrosilylation reaction catalysed by platinum complexes immobilized on bipyridine-periodic mesoporous organosilicas

2019 ◽  
Vol 48 (17) ◽  
pp. 5534-5540 ◽  
Author(s):  
Yuki Naganawa ◽  
Yoshifumi Maegawa ◽  
Haiqing Guo ◽  
Sandeep Suryabhan Gholap ◽  
Shinji Tanaka ◽  
...  
Keyword(s):  
Platinum Complex ◽  
Platinum Complexes ◽  
Product Yield ◽  
Periodic Mesoporous Organosilica ◽  
Hydrosilylation Reaction ◽  
Periodic Mesoporous Organosilicas ◽  
Mesoporous Organosilica ◽  
Mesoporous Organosilicas

A platinum complex immobilized on a bipyridine-periodic mesoporous organosilica (BPy-PMO) effectively catalysed the hydrosilylation reaction and showed good reusability without the loss of the product yield.

Effects of Buffers and pH on the Reaction of atrans-Platinum Complex with 5′-Guanosine Monophosphate

2015 ◽  
Vol 2015 (29) ◽  
pp. 4914-4920 ◽  
Author(s):  
Chan Li ◽  
Yi Ding ◽  
Lanjun Cheng ◽  
Yuchuan Zheng ◽  
Einar Sletten ◽  
...  
Keyword(s):  
Platinum Complex ◽  
Guanosine Monophosphate
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