Ultrasonic investigation of solute-solvent and solute-solute interactions in aqueous solutions of bases, nucleosides, and nucleotides. 3. Solute-solute interactions: studies of base stacking by ultrasonic velocity measurements

1980 ◽  
Vol 84 (7) ◽  
pp. 699-703 ◽  
Author(s):  
Paul Hemmes ◽  
A. A. Maevskii ◽  
V. A. Bukin ◽  
A. P. Sarvazyan
Keyword(s):  
Aqueous Solutions ◽  
Ultrasonic Velocity ◽  
Velocity Measurements ◽  
Base Stacking ◽  
Solute Interactions ◽  
Ultrasonic Investigation

Apparent molar volume and adiabatic compressibility studies of aqueous solutions of some drug compounds at 25 °C

1989 ◽  
Vol 67 (4) ◽  
pp. 727-735 ◽  
Author(s):  
Mohammad Iqbal ◽  
R. E. Verrall
Keyword(s):  
Aqueous Solutions ◽  
Protein Interactions ◽  
Adiabatic Compressibility ◽  
Structural Features ◽  
Aromatic Rings ◽  
Velocity Measurements ◽  
Drug Molecules ◽  
Aqueous Solvent ◽  
Solute Interactions ◽  
Apparent Molar Adiabatic Compressibilities

Apparent molar adiabatic compressibilities and volumes of aqueous solutions of the following drugs (sodium salicylate, methyl orange, L-tryptophan, phenol, and the hydrochloride salts of propranalol, procaine, pilocarpene, and ephedrine) have been calculated from high precision density and sound velocity measurements at 25 °C. These drugs are considered important in several biochemical phenomena such as anomalous protein binding, anesthesia, or unique structure–activity relationship and this study is part of a comprehensive investigation of drug–protein interactions in biological systems. The data are qualitatively interpreted in terms of solute–solvent and solute–solute interactions. Some plausible modes of drug hydration are discussed with particular reference to the structure of the drug molecules. The adiabatic compressibility shows a strong correlation with the hydrational behaviour of the solute molecule and appears to be sensitive to the structural features of the solute, such as shape, size, branching, and presence of aromatic rings. It is argued that these aspects are important in terms of considering the geometrical fit of the solute into the ordered form of the aqueous solvent surrounding these solutes. Keywords: apparent molar adiabatic compressibilities, apparent molar volumes, hydration of drugs.

scholarly journals The Ultrasonic Velocity and Absorption of Aqueous Solutions of Polyvinyl Alcohol

1964 ◽  
Vol 37 (4) ◽  
pp. 559-563 ◽  
Author(s):  
Kiyoshi Arakawa ◽  
Nobuo Takenaka ◽  
Mineo Watase ◽  
Kazunari Kubota
Keyword(s):  
Polyvinyl Alcohol ◽  
Aqueous Solutions ◽  
Ultrasonic Velocity
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