A new class of Norrish type I processes: .alpha.-bond cleavage upon 1(n,.pi.*(C = O)) excitation in the acid halides

1992 ◽  
Vol 96 (5) ◽  
pp. 2021-2023 ◽  
Author(s):  
M. D. Person ◽  
P. W. Kash ◽  
L. J. Butler
Keyword(s):  
Bond Cleavage ◽  
Type I ◽  
New Class ◽  
Norrish Type

Structural Effects on the Norrish Type I α-Bond Cleavage of Tropospherically Important Carbonyls

2019 ◽  
Vol 123 (48) ◽  
pp. 10381-10396
Author(s):  
Keiran N. Rowell ◽  
Scott H. Kable ◽  
Meredith J. T. Jordan
Keyword(s):  
Bond Cleavage ◽  
Type I ◽  
Structural Effects ◽  
Norrish Type

scholarly journals Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response

2017 ◽  
Vol 61 (10) ◽  
Author(s):  
Marianne Lucas-Hourani ◽  
Daniel Dauzonne ◽  
Hélène Munier-Lehmann ◽  
Samira Khiar ◽  
Sébastien Nisole ◽  
...  
Keyword(s):  
Metabolic Pathway ◽  
Defense Mechanisms ◽  
De Novo ◽  
Pyrimidine Biosynthesis ◽  
Interferon Response ◽  
Type I ◽  
Innate Defense ◽  
New Class ◽  
Biosynthesis Inhibitors ◽  
Tightly Coupled

ABSTRACT De novo pyrimidine biosynthesis is a key metabolic pathway involved in multiple biosynthetic processes. Here, we identified an original series of 3-(1H-indol-3-yl)-2,3-dihydro-4H-furo[3,2-c]chromen-4-one derivatives as a new class of pyrimidine biosynthesis inhibitors formed by two edge-fused polycyclic moieties. We show that identified compounds exhibit broad-spectrum antiviral activity and immunostimulatory properties, in line with recent reports linking de novo pyrimidine biosynthesis with innate defense mechanisms against viruses. Most importantly, we establish that pyrimidine deprivation can amplify the production of both type I and type III interferons by cells stimulated with retinoic acid-inducible gene 1 (RIG-I) ligands. Altogether, our results further expand the current panel of pyrimidine biosynthesis inhibitors and illustrate how the production of antiviral interferons is tightly coupled to this metabolic pathway. Functional and structural similarities between this new chemical series and dicoumarol, which was reported before to inhibit pyrimidine biosynthesis at the dihydroorotate dehydrogenase (DHODH) step, are discussed.

1‐Aryl‐2‐(triisopropylsilyl)ethane‐1,2‐diones: Toward a New Class of Visible Type I Photoinitiators for Free Radical Polymerization of Methacrylates

2019 ◽  
Vol 40 (20) ◽  
pp. 1900319 ◽  
Author(s):  
Julie Kirschner ◽  
Alexandre Baralle ◽  
Bernadette Graff ◽  
Jean‐Michel Becht ◽  
Joachim E. Klee ◽  
...  
Keyword(s):  
Free Radical ◽  
Radical Polymerization ◽  
Free Radical Polymerization ◽  
Type I ◽  
New Class

2D NMR Nutation Analysis of Non-Thermal Polarization of Coupled Multi-Spin Systems

2003 ◽  
Vol 217 (12) ◽  
pp. 1641-1659 ◽  
Author(s):  
K. L. Ivanov ◽  
K. Miesel ◽  
Hans-Martin Vieth ◽  
A. V. Yurkovskaya ◽  
R. Z. Sagdeev
Keyword(s):  
Pulse Length ◽  
2D Nmr ◽  
Mutual Orientation ◽  
Type I ◽  
Equilibrium System ◽  
Rate Determining Step ◽  
Chemically Induced ◽  
Norrish Type ◽  
Radio Frequency Excitation ◽  
Thermal Polarization

AbstractA new, convenient method of analyzing the spin polarization of a non-equilibrium system of N coupled nuclei is described and applied to photo-reactions exhibiting chemically induced dynamic nuclear polarization (CIDNP). It is based on the Fourier analysis of the variation of NMR line intensities as a function of the radio frequency excitation pulse length. A relationship between the spectral components at various harmonic order and the alignment in the spin multiplet is established. In application to the Norrish type I photolysis of cyclodecanone we demonstrate that at low magnetic field the rate determining step in the reaction kinetics depends on the mutual orientation of at least four pairs of non-equivalent spins.

Naphthalimide Aryl Sulfide Derivative Norrish Type I Photoinitiators with Excellent Stability to Sunlight under Near-UV LED

2019 ◽  
Vol 52 (4) ◽  
pp. 1707-1717 ◽  
Author(s):  
Jia Yu ◽  
Yanjing Gao ◽  
Shengling Jiang ◽  
Fang Sun
Keyword(s):  
Type I ◽  
Uv Led ◽  
Norrish Type ◽  
Aryl Sulfide ◽  
Excellent Stability
Sign in / Sign up

Export Citation Format

Share Document