Cholesterol solubility by bile salts in pure and mixed states with various additives

1991 ◽  
Vol 95 (11) ◽  
pp. 4529-4534 ◽  
Author(s):  
A. Bandyopadhyay ◽  
S. P. Moulik
Keyword(s):  
Bile Salts ◽  
Mixed States ◽  
Cholesterol Solubility

scholarly journals In Vitro Hypocholesterolemic Effect of Coffee Compounds

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 437
Author(s):  
Filipe Manuel Coreta-Gomes ◽  
Guido R. Lopes ◽  
Cláudia P. Passos ◽  
Inês M. Vaz ◽  
Fernanda Machado ◽  
...  
Keyword(s):  
Bile Salt ◽  
Bile Salts ◽  
Soluble Fiber ◽  
Hexane Extraction ◽  
Selective Precipitation ◽  
Food Ingredients ◽  
Espresso Coffee ◽  
Coffee Lipids ◽  
Cholesterol Solubility

(1) Background: Cholesterol bioaccessibility is an indicator of cholesterol that is available for absorption and therefore can be a measure of hypocholesterolemic potential. In this work, the effect of commercial espresso coffee and coffee extracts on cholesterol solubility are studied in an in vitro model composed by glycodeoxycholic bile salt, as a measure of its bioaccessibility. (2) Methods: Polysaccharide extracts from coffees obtained with different extraction conditions were purified by selective precipitation with ethanol, and their sugars content were characterized by GC-FID. Hexane extraction allowed us to obtain the coffee lipids. Espresso coffee samples and extracts were tested regarding their concentration dependence on the solubility of labeled 13C-4 cholesterol by bile salt micelles, using quantitative 13C NMR. (3) Results and Discussion: Espresso coffee and coffee extracts were rich in polysaccharides, mainly arabinogalactans and galactomannans. These polysaccharides decrease cholesterol solubility and, simultaneously, the bile salts’ concentration. Coffee lipid extracts were also found to decrease cholesterol solubility, although not affecting bile salt concentration. (4) Conclusions: Coffee soluble fiber, composed by the arabinogalactans and galactomannans, showed to sequester bile salts from the solution, leading to a decrease in cholesterol bioaccessibility. Coffee lipids also decrease cholesterol bioaccessibility, although the mechanism of action identified is the co-solubilization in the bile salt micelles. The effect of both polysaccharides and lipids showed to be additive, representing the overall effect observed in a typical espresso coffee. The effect of polysaccharides and lipids on cholesterol bioaccessibility should be accounted on the formulation of hypocholesterolemic food ingredients.

The Biological Importance of Bile Salts

1979 ◽  
Vol 7 (6) ◽  
pp. 1323-1323
Author(s):  
H. DANIELSSON
Keyword(s):  
Bile Salts ◽  
Biological Importance

Functional intravital two-photon based imaging of bile salts transport in cholestasis: mechanisms and consequences of bile infarcts formation

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
A Ghallab ◽  
U Hofmann ◽  
N Vartak ◽  
R Hassan ◽  
P Godoy ◽  
...  
Keyword(s):  
Bile Salts ◽  
Two Photon

Metabolism of Bile Salts by Alimentary Bacteria During Transit in the Human Small Intestine

1994 ◽  
Vol 8 (4) ◽  
Author(s):  
P. Marteau ◽  
M. F. Gerhardt ◽  
A. Myara ◽  
E. Bouvier ◽  
F. Trivin ◽  
...  
Keyword(s):  
Small Intestine ◽  
Bile Salts ◽  
Human Small Intestine
Sign in / Sign up

Export Citation Format

Share Document