Optically induced Kerr constants for pure liquids: homologous series of n-alkanes, 1-alkenes, and 1-alkynes

1993 ◽  
Vol 97 (8) ◽  
pp. 1511-1514 ◽  
Author(s):  
Neil J. Harrison ◽  
Barry R. Jennings
Keyword(s):  
Homologous Series ◽  
Kerr Constants ◽  
Optically Induced

scholarly journals Measurements of dc Kerr Constants for a Homologous Series of Nematic Compounds

1977 ◽  
Vol 43 (3-4) ◽  
pp. 287-294 ◽  
Author(s):  
T. Bischofberger ◽  
Robert Yu ◽  
Y. R. Shen
Keyword(s):  
Homologous Series ◽  
Kerr Constants

The Kerr constants and relaxation times in the isotropic phase of nematic homologous series

1978 ◽  
Vol 69 (4) ◽  
pp. 276-278 ◽  
Author(s):  
R. Yamamoto ◽  
S. Ishihara ◽  
S. Hayakawa ◽  
K. Morimoto
Keyword(s):  
Homologous Series ◽  
Relaxation Times ◽  
Isotropic Phase ◽  
Kerr Constants

NOVEL SMECTIC POLYMORPHIC BEHAVIOUR IN HOMOLOGOUS SERIES OF MESOGENS

1975 ◽  
Vol 36 (C1) ◽  
pp. C1-365-C1-374 ◽  
Author(s):  
D. COATES ◽  
G. W. GRAY
Keyword(s):  
Homologous Series

COMPARISON OF OPTICALLY INDUCED LOCALIZED STATES IN CHALCOGENIDE GLASSES AND THEIR CRYSTALLINE COUNTERPARTS

1981 ◽  
Vol 42 (C4) ◽  
pp. C4-383-C4-386 ◽  
Author(s):  
S. G. Bishop ◽  
B. V. Shanabrook ◽  
U. Strom ◽  
P. C. Taylor
Keyword(s):  
Chalcogenide Glasses ◽  
Localized States ◽  
Optically Induced

Homologation: A Versatile Molecular Modification Strategy to Drug Discovery

2019 ◽  
Vol 19 (19) ◽  
pp. 1734-1750 ◽  
Author(s):  
Lídia M. Lima ◽  
Marina A. Alves ◽  
Daniel N. do Amaral
Keyword(s):  
Protein Structure ◽  
Homologous Series ◽  
Molecular Conformation ◽  
Chemical Properties ◽  
Lead Optimization ◽  
Pharmacokinetic Property ◽  
Molecular Modification ◽  
Physico Chemical ◽  
Pharmacokinetic Properties ◽  
Lead Identification

Homologation is a concept introduced by Gerhard in 1853 to describe a homologous series in organic chemistry. Since then, the concept has been adapted and used in medicinal chemistry as one of the most important strategies for molecular modification. The homologation types, their influence on physico-chemical properties and molecular conformation are presented and discussed. Its application in lead-identification and lead optimization steps, as well as its impact on pharmacodynamics/pharmacokinetic properties and on protein structure is highlighted from selected examples. <p> • Homologation: definition and types <p> • Homologous series in nature <p> • Comparative physico-chemical and conformational properties <p> • Application in lead-identification and lead-optimization <p> • Impact on pharmacodynamic property <p> • Impact on pharmacokinetic property <p> • Impact on protein structure <p> • Concluding remarks <p> • Acknowledgment <p> • References

Sign in / Sign up

Export Citation Format

Share Document