Free Radical Production by Sonolysis of Aqueous Mixtures of N,N-Dimethylformamide: An EPR Spin Trapping Study

1995 ◽  
Vol 99 (16) ◽  
pp. 5970-5976 ◽  
Author(s):  
Vladimir Misik ◽  
Louis J. Kirschenbaum ◽  
Peter Riesz
Keyword(s):  
Free Radical ◽  
Spin Trapping ◽  
Aqueous Mixtures ◽  
Free Radical Production ◽  
Radical Production ◽  
Epr Spin Trapping

scholarly journals The oxidation of oxyhaemoglobin by glyceraldehyde and other simple monosaccharides

1984 ◽  
Vol 217 (3) ◽  
pp. 615-622 ◽  
Author(s):  
P J Thornalley ◽  
S P Wolff ◽  
M J C Crabbe ◽  
A Stern
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Phosphate Buffer ◽  
Spin Trap ◽  
Spin Trapping ◽  
Free Radical Production ◽  
Radical Production ◽  
Hydroxyalkyl Radical ◽  
Aldehyde Derivative

Glyceraldehyde and other simple monosaccharides oxidize oxyhaemoglobin to methaemoglobin in phosphate buffer at pH 7.4 and 37 degrees C, with the concomitant production of H2O2 and an alpha-oxo aldehyde derivative of the monosaccharide. Simple monosaccharides also reduce methaemoglobin to ferrohaemichromes (non-intact haemoglobin) at pH 7.4 and 37 degrees C. Carbonmonoxyhaemoglobin is unreactive towards oxidation by autoxidizing glyceraldehyde. Free-radical production from autoxidizing monosaccharides with haemoglobins was observed by the e.s.r. technique of spin trapping with the spin trap 5,5-dimethyl-l-pyrroline N-oxide. Hydroxyl and l-hydroxyalkyl radical production observed from monosaccharide autoxidation was quenched in the presence of oxyhaemoglobin and methaemoglobin. The haemoglobins appear to quench the free radicals by reaction with the free radicals and/or the ene-diol precursor of the free radical.

Chemiluminescence as an index of drug-induced free radical production in pancreatic islets

Diabetes ◽  
1984 ◽  
Vol 33 (2) ◽  
pp. 160-163 ◽  
Author(s):  
K. Asayama ◽  
D. English ◽  
A. E. Slonim ◽  
I. M. Burr
Keyword(s):  
Free Radical ◽  
Pancreatic Islets ◽  
Drug Induced ◽  
Free Radical Production ◽  
Radical Production
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