A Phase Study of Commercial Soap and Water

1941 ◽  
Vol 33 (8) ◽  
pp. 1049-1055 ◽  
Author(s):  
James W. McBain ◽  
Marjorie J. Vold ◽  
John L. Porter
Keyword(s):  
Phase Study ◽  
Commercial Soap

scholarly journals Three-Dimensional Analysis of the In Vivo Motion of Implantable Cardioverter Defibrillator Leads

2021 ◽  
Author(s):  
Tamas Szili-Torok ◽  
Jens Rump ◽  
Torsten Luther ◽  
Sing-Chien Yap
Keyword(s):  
Three Dimensional ◽  
Second Phase ◽  
Two Phase ◽  
Maximum Curvature ◽  
Phase Study ◽  
Absolute Curvature ◽  
Icd Leads ◽  
Lead Testing ◽  
Design And Testing

Abstract Better understanding of the lead curvature, movement and their spatial distribution may be beneficial in developing lead testing methods, guiding implantations and improving life expectancy of implanted leads. Objective The aim of this two-phase study was to develop and test a novel biplane cine-fluoroscopy-based method to evaluate input parameters for bending stress in leads based on their in vivo 3D motion using precisely determined spatial distributions of lead curvatures. Potential tensile, compressive or torque forces were not subjects of this study. Methods A method to measure lead curvature and curvature evolution was initially tested in a phantom study. In the second phase using this model 51 patients with implanted ICD leads were included. A biplane cine-fluoroscopy recording of the intracardiac region of the lead was performed. The lead centerline and its motion were reconstructed in 3D and used to define lead curvature and curvature changes. The maximum absolute curvature Cmax during a cardiac cycle, the maximum curvature amplitude Camp and the maximum curvature Cmax@amp at the location of Camp were calculated. These parameters can be used to characterize fatigue stress in a lead under cyclical bending. Results The medians of Camp and Cmax@amp were 0.18 cm−1 and 0.42 cm−1, respectively. The median location of Cmax was in the atrium whereas the median location of Camp occurred close to where the transit through the tricuspid valve can be assumed. Increased curvatures were found for higher slack grades. Conclusion Our results suggest that reconstruction of 3D ICD lead motion is feasible using biplane cine-fluoroscopy. Lead curvatures can be computed with high accuracy and the results can be implemented to improve lead design and testing.

Initial development of the Dance Imagery Questionnaire for Children (DIQ-C): establishing content validity

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Irene Muir ◽  
Krista Munroe-Chandler
Keyword(s):  
Content Validity ◽  
Cognitive Interviews ◽  
Item Pool ◽  
Initial Development ◽  
Expert Rating ◽  
Content Relevance ◽  
Phase Study ◽  
Initial Item ◽  
Item Content ◽  
Dance Imagery

AbstractGiven the differences between young dancers’ and adult dancers’ use of imagery, a valid and reliable questionnaire specific to young dancers was necessary. The current study is the first phase of a multi-phase study in the development of the Dance Imagery Questionnaire for Children (DIQ-C). Specifically, the purpose of this study was to establish content validity of the DIQ-C. This was achieved through the following three stages: (1) definition, item, and scale development, (2) assessment of item clarity and appropriateness via cognitive interviews, and (3) assessment of item-content relevance via an expert rating panel. Guided by previous qualitative research with young dancers, 46 items representing seven subscales (i.e., imagery types) were developed. The initial item pool was then implemented during cognitive interviews with 16 dancers (15 females; Mage=10.63, SD=1.82), which led to the removal of 13 items and the modification of 21 items. Consequently, the revised 33-item pool was then administered to an expert panel of four imagery researchers and four dance instructors to measure item-content relevance. This resulted in the removal of eight items, the revision of four items, and the merging of two subscales. Overall, the current study provides content validity evidence for a 25-item pool (representing five subscales) to be used in further development of the DIQ-C (i.e., identifying and establishing factor structure).

scholarly journals Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: a case–control discovery phase study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
E. W. Harville ◽  
Y.-Y. Li ◽  
K. Pan ◽  
S. McRitchie ◽  
W. Pathmasiri ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Predictive Power ◽  
Gestational Hypertension ◽  
Predictive Biomarkers ◽  
First Trimester ◽  
Resonance Spectroscopy ◽  
Renal Secretion ◽  
Global Alliance ◽  
Phase Study ◽  
High Resolution Mass Spectroscopy

AbstractUnderstanding of causal biology and predictive biomarkers are lacking for hypertensive disorders of pregnancy (HDP) and preterm birth (PTB). First-trimester serum specimens from 51 cases of HDP, including 18 cases of pre-eclampsia (PE) and 33 cases of gestational hypertension (GH); 53 cases of PTB; and 109 controls were obtained from the Global Alliance to Prevent Prematurity and Stillbirth repository. Metabotyping was conducted using liquid chromatography high resolution mass spectroscopy and nuclear magnetic resonance spectroscopy. Multivariable logistic regression was used to identify signals that differed between groups after controlling for confounders. Signals important to predicting HDP and PTB were matched to an in-house physical standards library and public databases. Pathway analysis was conducted using GeneGo MetaCore. Over 400 signals for endogenous and exogenous metabolites that differentiated cases and controls were identified or annotated, and models that included these signals produced substantial improvements in predictive power beyond models that only included known risk factors. Perturbations of the aminoacyl-tRNA biosynthesis, l-threonine, and renal secretion of organic electrolytes pathways were associated with both HDP and PTB, while pathways related to cholesterol transport and metabolism were associated with HDP. This untargeted metabolomics analysis identified signals and common pathways associated with pregnancy complications.

Multicenter Transversal Two-Phase Study to Determine a National Prevalence of Epilepsy in Algeria

2012 ◽  
Vol 39 (2) ◽  
pp. 131-134 ◽  
Author(s):  
Dalila Moualek ◽  
Lamia Ali Pacha ◽  
Samira Abrouk ◽  
Mohamed Islam Kediha ◽  
Sonia Nouioua ◽  
...  
Keyword(s):  
Two Phase ◽  
Phase Study ◽  
National Prevalence

A condensed phase study of the benzene B2u←A1g three-photon transition

1986 ◽  
Vol 85 (6) ◽  
pp. 3155-3164 ◽  
Author(s):  
J. R. Cable ◽  
A. C. Albrecht
Keyword(s):  
Condensed Phase ◽  
Photon Transition ◽  
Phase Study

Endometrial Adenocarcinoma in SurePath™ Cervical Samples: Cytological Features Revisited

2016 ◽  
Vol 60 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Nalini Gupta ◽  
John Crossley ◽  
Nick Dudding ◽  
John H.F. Smith
Keyword(s):  
Phase 1 ◽  
Endometrial Adenocarcinoma ◽  
Nuclear Chromatin ◽  
Phase 2 ◽  
Cervical Lesions ◽  
Two Phase ◽  
Endometrial Cells ◽  
Phase Study ◽  
Cytological Features ◽  
Liquid Based Cytology

Objective: The cytomorphological criteria of malignant endometrial lesions in cervical samples are less well described than those of cervical lesions. We wished to investigate if there were features in SurePath™ liquid-based cytology samples that would facilitate more accurate differentiation between benign and malignant endometrial cells. Study Design: This was a two-phase study, with a review of all SurePath™ samples reported as endometrial adenocarcinoma (n = 42) evaluating 12 cytological features in the first phase. In phase 2 (test set), all initial cases plus an additional 83 cases were reviewed using these 12 cytological features to predict the outcome. Results: Out of 12 cytological features evaluated in phase 1 (training set), nuclear chromatin pattern, apoptotic bodies and tingible body macrophages were found to be the most significant features determining malignant histological outcome. These 12 cytological features were re-evaluated in phase 2 (n = 125). Of 125 cases, 54 had a benign and 71 had a malignant or premalignant histological outcome, with a positive predictive value of 56.8%. Conclusion: Granular nuclear chromatin, tingible body macrophages and apoptosis in the background are the most significant factors in determining whether endometrial cells present in cervical samples represent malignancy or are benign. Using these features, relatively accurate predictions of endometrial pathology can be made.

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