Mixed Micelle Formation between an Amino Acid-Based Anionic Gemini Surfactant and Bile Salts

2014 ◽  
Vol 53 (24) ◽  
pp. 10112-10118 ◽  
Author(s):  
Célia M. C. Faustino ◽  
Cláudia S. Serafim ◽  
Inês N. Ferreira ◽  
Mafalda A. Branco ◽  
António R. T. Calado ◽  
...  
Keyword(s):  
Amino Acid ◽  
Bile Salts ◽  
Mixed Micelle ◽  
Gemini Surfactant ◽  
Micelle Formation ◽  
Mixed Micelle Formation ◽  
Anionic Gemini Surfactant

Influence of taurocholate, taurochenodeoxycholate, and taurodehydrocholate on sulfobromophthalein transport into bile.

1979 ◽  
Vol 236 (1) ◽  
pp. E10
Author(s):  
S Binet ◽  
Y Delage ◽  
S Erlinger
Keyword(s):  
Bile Salts ◽  
Mixed Micelle ◽  
Mixed Micelles ◽  
Important Determinant ◽  
Micelle Formation ◽  
Similar Increase ◽  
Mixed Micelle Formation ◽  
Series Of Experiments

To test the hypothesis that incorporation of sulfobromophthalein (BSP) into mixed micelles could account for the increase in its biliary transport maximum (Tmax) by bile salts, we have compared in hamsters the influence on BSP Tmax of taurocholate and taurochenodeoxycholate (two micelle-forming physiological bile salts) to that of taurodehydrocholate, a bile salt which, in vitro, does not form micelles. In a first series of experiments, it was observed that taurocholate and taurochenodeoxycholate increased the secretion of phospholipid (40 and 53%, respectively), and cholesterol (50 and 110%, respectively), whereas taurodehydrocholate decreased the secretion of phospholipid (-31%) and cholesterol (-43%). This result suggests that, in vivo, taurodehydrocholate or its metabolites do not form mixed micelles. In a second series of experiments, it was seen that the three bile salts induced a similar increase in BSP Tmax (63% with taurocholate, 52% with taurochenodeoxycholate, and 51% with taurodehydrocholate). These results provide circumstantial evidence for the hypothesis that mixed micelle formation is not an important determinant of maximal BSP secretion into bile.

Biliary Inter-Relationship between Phospholipid, Bilirubin and Taurocholate in the Anaesthetized Rat

1984 ◽  
Vol 67 (5) ◽  
pp. 499-504 ◽  
Author(s):  
J. J. García-Marín ◽  
A. Esteller
Keyword(s):  
Body Weight ◽  
Bile Flow ◽  
Bile Salts ◽  
Mixed Micelle ◽  
Enterohepatic Circulation ◽  
Important Determinant ◽  
Sodium Taurocholate ◽  
Micelle Formation ◽  
Mixed Micelle Formation ◽  
Anaesthetized Rat

1. The interference between biliary phospholipid and bilirubin secretion was investigated in rats with bile fistulae, under conditions of normal and maximal bilirubin secretion. The enterohepatic circulation of bile salts was interrupted and the animals received infusions of sodium taurocholate, a micelle-forming physiological bile salt. 2. Sodium taurocholate infusion (0.19 μmol min−1 100 g−1 body weight) induced an increase in bile flow and phospholipid secretion, while basal bilirubin secretion was not increased. 3. Bilirubin infusion (0.26 μmol min−1 100 g−1 body weight) induced a decrease in basal and taurocholate-stimulated phospholipid secretion. Biliary mixed micelle formation was presumably altered during bilirubin infusion, although bile taurocholate concentration, taurocholate secretion rate and bile flow were not modified. 4. When sodium taurocholate was infused during bilirubin-decreased phospholipid secretion, this secretion was restored but maximal biliary bilirubin secretion was not increased. 5. These results provide circumstantial evidence for the hypothesis that mixed micelle formation is not an important determinant of maximal bilirubin transport into bile.

Mixed micelle formation between amino acid-based surfactants and phospholipids

2011 ◽  
Vol 359 (2) ◽  
pp. 493-498 ◽  
Author(s):  
Célia M.C. Faustino ◽  
António R.T. Calado ◽  
Luís Garcia-Rio
Keyword(s):  
Amino Acid ◽  
Mixed Micelle ◽  
Micelle Formation ◽  
Mixed Micelle Formation

Determination of Surfactants Based on Mixed-Micelle Formation

1995 ◽  
Vol 67 (11) ◽  
pp. 1872-1880 ◽  
Author(s):  
Dolores. Sicilia ◽  
Soledad. Rubio ◽  
Dolores. Perez-Bendito
Keyword(s):  
Mixed Micelle ◽  
Micelle Formation ◽  
Mixed Micelle Formation

scholarly journals Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Shuaijiang Jin ◽  
Roberto J. Brea ◽  
Andrew K. Rudd ◽  
Stuart P. Moon ◽  
Matthew R. Pratt ◽  
...  
Keyword(s):  
Mixed Micelle ◽  
Micelle Formation ◽  
Native Chemical Ligation ◽  
Chemical Ligation ◽  
Mixed Micelle Formation
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