Effect of Temperature and Pressure on the Behavior of Poly(ε-caprolactone) in the Presence of Supercritical Carbon Dioxide

2013 ◽  
Vol 52 (44) ◽  
pp. 15594-15601 ◽  
Author(s):  
Elena Markočič ◽  
Mojca Škerget ◽  
Željko Knez
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Effect Of Temperature ◽  
Temperature And Pressure ◽  
Supercritical Carbon

scholarly journals Effect of Temperature and Pressure on Surface Tension of Polystyrene in Supercritical Carbon Dioxide

2007 ◽  
Vol 111 (15) ◽  
pp. 3859-3868 ◽  
Author(s):  
H. Park ◽  
R. B. Thompson ◽  
N. Lanson ◽  
C. Tzoganakis ◽  
C. B. Park ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Surface Tension ◽  
Supercritical Carbon Dioxide ◽  
Effect Of Temperature ◽  
Temperature And Pressure ◽  
Supercritical Carbon

scholarly journals Experimental and thermodynamic modeling decitabine anti cancer drug solubility in supercritical carbon dioxide

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mahboubeh Pishnamazi ◽  
Samyar Zabihi ◽  
Sahar Jamshidian ◽  
Fatemeh Borousan ◽  
Ali Zeinolabedini Hezave ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Solubility Data ◽  
Effect Of Temperature ◽  
Cancer Drug ◽  
Direct Relation ◽  
Anti Cancer ◽  
Temperature And Pressure ◽  
The Cross ◽  
Supercritical Carbon

AbstractDesign and development of efficient processes for continuous manufacturing of solid dosage oral formulations is of crucial importance for pharmaceutical industry in order to implement the Quality-by-Design paradigm. Supercritical solvent-based manufacturing can be utilized in pharmaceutical processing owing to its inherent operational advantages. However, in order to evaluate the possibility of supercritical processing for a particular medicine, solubility measurement needs to be carried out prior to process design. The current work reports a systematic solubility analysis on decitabine as an anti-cancer medicine. The solvent is supercritical carbon dioxide at different conditions (temperatures and pressures), while gravimetric technique is used to obtain the solubility data for decitabine. The results indicated that the solubility of decitabine varies between 2.84 × 10–05 and 1.07 × 10–03 mol fraction depending on the temperature and pressure. In the experiments, temperature and pressure varied between 308–338 K and 12–40 MPa, respectively. The solubility of decitabine was plotted against temperature and pressure, and it turned out that the solubility had direct relation with the pressure due to the effect of pressure on solvating power of solvent. The effect of temperature on solubility was shown to be dependent on the cross-over pressure. Below the cross-over pressure, there is a reverse relation between temperature and solubility, while a direct relation was observed above the cross-over pressure (16 MPa). Theoretical study was carried out to correlate the solubility data using several thermodynamic-based models. The fitting and model calibration indicated that the examined models were of linear nature and capable to predict the measured decitabine solubilities with the highest average absolute relative deviation percent (AARD %) of 8.9%.

scholarly journals Thermodynamic modeling of solid solubility in supercritical carbon dioxide: Comparison between mixing rules

2013 ◽  
Vol 19 (3) ◽  
pp. 389-398 ◽  
Author(s):  
Hadi Baseri ◽  
Ali Haghighi-Asl ◽  
Nader Lotfollahi
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Thermodynamic Modeling ◽  
Pressure Range ◽  
The Other ◽  
Mixing Rules ◽  
Calculation Results ◽  
Temperature And Pressure ◽  
Robinson Equation ◽  
Supercritical Carbon

In this paper, Peng Robinson equation of state is used for thermodynamic modeling of the solubility of various solid components in the supercritical carbon dioxide. Moreover, the effects of three mixing rules of Van der Waals mixing rules, Panagiotopoulos and Reid mixing rules and modified Kwak and Mansoori mixing rules on the accuracy of calculation results were studied. Good correlations between calculated and experimental data were obtained in the wide temperature and pressure range. A comparison between used models shows that modified Kwak and Mansoori mixing rules give better correlations in comparison with the other mixing rules.

Research on Polypropylene Dyeing in Supercritical Carbon Dioxide

2011 ◽  
Vol 175-176 ◽  
pp. 646-650 ◽  
Author(s):  
Hong Jie Zhang ◽  
Zhi Li Zhong ◽  
Li Li Feng ◽  
Xiao Ping Quan
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Disperse Dyes ◽  
Polypropylene Fibers ◽  
Temperature And Pressure ◽  
Supercritical Carbon

Polypropylene fibers were dyed with Disperse dyes Blue 2B in Supercritical Carbon Dioxide at different temperature, pressure and time. The K/S value were determined and the effect of as temperature, pressure and dyeing time on the dyeing behaviours of disperse dyes on Polypropylene fibers were discussed. It was found that with the increase of dyeing temperature and pressure, the K/S value increased gradually, and dyeing effect was best after the fiber was dyed at 120 °C, 28 MPa for 20 min.

Free-Radical Chemistry in Supercritical Carbon Dioxide

2004 ◽  
Author(s):  
J. M. Tanko
Keyword(s):  
Carbon Dioxide ◽  
Free Radical ◽  
Supercritical Carbon Dioxide ◽  
Green Chemistry ◽  
Chemical Reactions ◽  
Environmentally Benign ◽  
Supercritical State ◽  
Liquid Phases ◽  
Temperature And Pressure ◽  
Supercritical Carbon

During the 1990s, the chemical industry has focused on ways to reduce and prevent pollution caused by chemical synthesis and manufacturing. The goal of this approach is to modify existing reaction conditions and/or to develop new chemistries that do not require the use of toxic reagents or solvents, or that do not produce toxic by-products. The terms “environmentally benign synthesis and processing” and “green chemistry” have been coined to describe this approach where the environmental impact of a process is as important an issue as reaction yield, efficiency, or cost. Most chemical reactions require the use of a solvent that may serve several functions in a reaction: for example, ensuring homogeneity of the reactants, facilitating heat transfer, extraction of a product (or by-product), or product purification via chromatography. However, because the solvent is only indirectly involved in a reaction (i.e., it is not consumed), its disposal becomes an important issue. Thus, one obvious approach to “green chemistry” is to identify alternative solvents that are nontoxic and/or environmentally benign. Supercritical carbon dioxide (sc CO2) has been identified as a solvent that may be a viable alternative to solvents such as CCl4, benzene, and chloroflurocarbons (CFCs), which are either toxic or damaging to the environment. The critical state is achieved when a substance is taken above its critical temperature and pressure (Tc, Pc). Above this point on a phase diagram, the gas and liquid phases become indistinguishable. The physical properties of the supercritical state (e.g., density, viscosity, solubility parameter, etc.) are intermediate between those of a gas and a liquid, and vary considerably as a function of temperature and pressure. The interest in sc CO2 specifically is related to the fact that CO2 is nontoxic and naturally occurring. The critical parameters of CO2 are moderate (Tc = 31 °C, Pc = 74 bar), which means that the supercritical state can be achieved without a disproportionate expenditure of energy. For these two reasons, there is a great deal of interest in sc CO2 as a solvent for chemical reactions. This chapter reviews the literature pertaining to free-radical reactions in sc CO2 solvent.

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