Chemical Degradation Studies on a Series of Dithiophosphinic Acids

2014 ◽  
Vol 53 (9) ◽  
pp. 3606-3611 ◽  
Author(s):  
Melissa E. Freiderich ◽  
Dean R. Peterman ◽  
John R. Klaehn ◽  
Philippe Marc ◽  
Lætitia H. Delmau
Keyword(s):  
Chemical Degradation ◽  
Dithiophosphinic Acids ◽  
Degradation Studies

scholarly journals 4-O-(1-carboxyethyl)-d-galactose. A new acidic sugar from the extracellular polysaccharide produced by Butyrivibrio fibrisolvens strain 49

1988 ◽  
Vol 256 (3) ◽  
pp. 769-773 ◽  
Author(s):  
R J Stack ◽  
T M Stein ◽  
R D Plattner
Keyword(s):  
Extracellular Polysaccharide ◽  
Chemical Degradation ◽  
Butyrivibrio Fibrisolvens ◽  
Degradation Studies

The structure of a new acidic sugar from the extracellular polysaccharide of Butyrivibrio fibrisolvens strain 49 was determined as 4-O-(1-carboxyethyl)-D-galactose on the basis of 13C-n.m.r. and 1H-n.m.r. spectroscopy, m.s. and chemical degradation studies.

Catecholate Siderophores from Chryseomonas luteola

1996 ◽  
Vol 51 (5-6) ◽  
pp. 281-285 ◽  
Author(s):  
M. Adolphs ◽  
K. Taraz ◽  
H. Budzikiewicz
Keyword(s):  
Culture Medium ◽  
2D Nmr ◽  
Chemical Degradation ◽  
Spectroscopic Methods ◽  
Iron Deficient ◽  
Nmr Techniques ◽  
Degradation Studies ◽  
Chryseomonas Luteola

Abstract Two catecholate siderophores (chrysobactin and chryseomonin) were isolated from an iron-deficient culture medium of Chryseomonas luteola. Their structures were elucidated by chemical degradation studies and spectroscopic methods, especially 2D-NMR techniques, and confirmed by synthesis. Chryseomonin constitutes a novel type of catecholate siderophore.

A generic fluticasone propionate and salmeterol dry powder inhaler: Evidence of usability, function, and robustness

2021 ◽  
Vol 42 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Donald P. Tashkin ◽  
Arkady Koltun ◽  
Róisín Wallace
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Fluticasone Propionate ◽  
Healthy Volunteers ◽  
Pulmonary Disease ◽  
Dry Powder Inhaler ◽  
Chemical Degradation ◽  
Chronic Obstructive ◽  
Dry Powder ◽  
Obstructive Pulmonary Disease ◽  
Flow Rates

Background: A generic combination of fluticasone propionate and salmeterol xinafoate inhalation powder in a premetered, multidose, nonreusable inhaler was recently approved. Objective: To assess the performance of the generic device. Methods: Findings from three studies with regard to device usability, function, and robustness were reviewed. Results: In a study to assess device function in patients and healthy volunteers, the generic device was successfully used by patients with asthma and chronic obstructive pulmonary disease who were either dry powder inhaler users or dry powder inhaler‐naive, even though they were not trained beyond being provided the instructions for use. In a study to measure inhaled flow rates generated by patients and healthy volunteers, the generic device consistently simulated the delivery of a full dose of drug, even to patients with severe respiratory disease and reduced inspiratory flow rates. Although the generic device had a slightly higher airflow resistance, this study demonstrated that this difference did not result in any clinically meaningful differences in terms of drug delivery. Pressure drop, a key parameter that drives the fluidization and aerosolization of the powder dose, was found to be comparable between the devices. In an open-label study, the generic device met all U.S. Food and Drug Administration specifications for device robustness after 21.5 days of twice-daily dosing via oral inhalation among 111 participants with asthma or chronic obstructive pulmonary disease. All inhalers tested demonstrated conformity with a pharmacopeia with respect to key quality parameters (assay, delivered dose uniformity, aerodynamic size distribution). There was no evidence of chemical degradation of the active ingredients, nor of microbial or water ingress into the powder, as a result of inhaler use.

Mechanism of Perfluorsulfonic Acid Membrane Chemical Degradation Under Low RH Conditions

2013 ◽  
Vol 50 (2) ◽  
pp. 907-918 ◽  
Author(s):  
F. D. Coms ◽  
H. Xu ◽  
T. McCallum ◽  
C. Mittelsteadt
Keyword(s):  
Chemical Degradation

Preparation and characterisation of liquid epoxidised natural rubber in latex stage by chemical degradation

2021 ◽  
Author(s):  
Nurul Hayati Yusof ◽  
Dazylah Darji ◽  
Fatimah Rubaizah Mohd Rasdi ◽  
Krishna Veni Baratha Nesan
Keyword(s):  
Natural Rubber ◽  
Chemical Degradation
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