Closed-Loop Control of Fed-Batch Bioreactors:  A Shrinking-Horizon Approach

2004 ◽  
Vol 43 (13) ◽  
pp. 3381-3393 ◽  
Author(s):  
Abhishek S. Soni ◽  
Robert S. Parker
Keyword(s):  
Closed Loop ◽  
Closed Loop Control ◽  
Fed Batch ◽  
Loop Control ◽  
Batch Bioreactors

scholarly journals Neural Network-Based State Estimation for a Closed-Loop Control Strategy Applied to a Fed-Batch Bioreactor

Complexity ◽  
2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Santiago Rómoli ◽  
Mario Serrano ◽  
Francisco Rossomando ◽  
Jorge Vega ◽  
Oscar Ortiz ◽  
...  
Keyword(s):  
Neural Network ◽  
Closed Loop ◽  
Rbf Neural Network ◽  
Control Strategies ◽  
Tracking Error ◽  
Closed Loop Control ◽  
Online Information ◽  
Fed Batch ◽  
Loop Control ◽  
Batch Bioreactor

The lack of online information on some bioprocess variables and the presence of model and parametric uncertainties pose significant challenges to the design of efficient closed-loop control strategies. To address this issue, this work proposes an online state estimator based on a Radial Basis Function (RBF) neural network that operates in closed loop together with a control law derived on a linear algebra-based design strategy. The proposed methodology is applied to a class of nonlinear systems with three types of uncertainties: (i) time-varying parameters, (ii) uncertain nonlinearities, and (iii) unmodeled dynamics. To reduce the effect of uncertainties on the bioreactor, some integrators of the tracking error are introduced, which in turn allow the derivation of the proper control actions. This new control scheme guarantees that all signals are uniformly and ultimately bounded, and the tracking error converges to small values. The effectiveness of the proposed approach is illustrated on the basis of simulated experiments on a fed-batch bioreactor, and its performance is compared with two controllers available in the literature.

Closed-loop control of fed-batch cultures of recombinantEscherichia coli using on-line HPLC

1994 ◽  
Vol 44 (7) ◽  
pp. 819-829 ◽  
Author(s):  
Claire Turner ◽  
Malcolm E. Gregory ◽  
Nina F. Thornhill
Keyword(s):  
Closed Loop ◽  
Closed Loop Control ◽  
Fed Batch ◽  
Loop Control ◽  
Batch Cultures ◽  
On Line

scholarly journals Adaptive Control of CO2 Production during Milk Fermentation in a Batch Bioreactor

Mathematics ◽  
2021 ◽  
Vol 9 (15) ◽  
pp. 1712
Author(s):  
Jožef Ritonja
Keyword(s):  
Adaptive Control ◽  
Control System ◽  
Closed Loop ◽  
Closed Loop Control ◽  
Adaptive Control System ◽  
Loop Control ◽  
Batch Bioreactor ◽  
Closed Loop Control System ◽  
Loop Control System ◽  
Batch Bioreactors

The basic characteristic of batch bioreactors is their inability to inflow or outflow the substances during the fermentation process. This follows in the simple construction and maintenance, which is the significant advantage of batch bioreactors. Unfortunately, this characteristic also results in the inability of the current industrial and laboratory batch bioreactors to control fermentation production during the process duration. In some recent studies, it was shown that changing the temperature could influence the execution of the fermentation process. The presented paper shows that this phenomenon could be used to develop the closed-loop control system for the fermentation production control in batch bioreactors. First, based on theoretical work, experiments, and numerical methods, the appropriate structure of the mathematical model was determined and parameters were identified. Next, the closed-loop control system structure for batch bioreactor was proposed, and the linear and adaptive control system based on this structure and the derived and identified model were developed. Both modeling and adaptive control system design are new and represent original contributions. As expected, due to the non-linearity of the controlled plant, the adaptive control represents a more successful approach. The simulation and experimental results were used to confirm the applicability of the proposed solution.

The Impact of Visual Feedback Type on the Mastery of Visuo-Motor Transformations

2012 ◽  
Vol 220 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Sandra Sülzenbrück
Keyword(s):  
Empirical Research ◽  
Visual Feedback ◽  
Closed Loop ◽  
Motor Planning ◽  
Visual Input ◽  
Closed Loop Control ◽  
Loop Control ◽  
Feedback Type ◽  
Effective Use ◽  
The Impact

For the effective use of modern tools, the inherent visuo-motor transformation needs to be mastered. The successful adjustment to and learning of these transformations crucially depends on practice conditions, particularly on the type of visual feedback during practice. Here, a review about empirical research exploring the influence of continuous and terminal visual feedback during practice on the mastery of visuo-motor transformations is provided. Two studies investigating the impact of the type of visual feedback on either direction-dependent visuo-motor gains or the complex visuo-motor transformation of a virtual two-sided lever are presented in more detail. The findings of these studies indicate that the continuous availability of visual feedback supports performance when closed-loop control is possible, but impairs performance when visual input is no longer available. Different approaches to explain these performance differences due to the type of visual feedback during practice are considered. For example, these differences could reflect a process of re-optimization of motor planning in a novel environment or represent effects of the specificity of practice. Furthermore, differences in the allocation of attention during movements with terminal and continuous visual feedback could account for the observed differences.

118-LB: Glucose Variability throughout the Menstrual Cycle on Closed-Loop Control in Type 1 DM

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 118-LB
Author(s):  
CAROL J. LEVY ◽  
GRENYE OMALLEY ◽  
SUE A. BROWN ◽  
DAN RAGHINARU ◽  
YOGISH C. KUDVA ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Closed Loop ◽  
Glucose Variability ◽  
Closed Loop Control ◽  
Loop Control ◽  
Type 1 Dm

101-LB: Eighteen-Month Use of Closed-Loop Control (CLC): A Randomized, Controlled Trial

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 101-LB
Author(s):  
SUE A. BROWN ◽  
DAN RAGHINARU ◽  
BRUCE A. BUCKINGHAM ◽  
YOGISH C. KUDVA ◽  
LORI M. LAFFEL ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Closed Loop ◽  
Controlled Trial ◽  
Closed Loop Control ◽  
Loop Control ◽  
Randomized Controlled
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