Design and Synthesis of NovelN,N‘-Bis(1-carboxy-15-hydroxy-n-pentadec-8-yl)alkyl or -Aryl Diamides by Acid-Catalyzed Addition of Nitriles To Ambrettoleic Acid via Amido−Imidol Tautomerization:  An Approach for Their Biological Importance and Possible Industrial Utilization

2004 ◽  
Vol 43 (23) ◽  
pp. 7435-7444 ◽  
Author(s):  
Kallappa M. Hosamani ◽  
Raviraj S. Pattanashettar
Keyword(s):  
Design And Synthesis ◽  
Biological Importance ◽  
Industrial Utilization ◽  
Acid Catalyzed

Formic acid catalyzed isomerization of protonated cytosine: a lower barrier reaction for tautomer production of potential biological importance

2017 ◽  
Vol 19 (21) ◽  
pp. 13515-13523 ◽  
Author(s):  
Lingxia Jin ◽  
Mengdan Lv ◽  
Mengting Zhao ◽  
Rui Wang ◽  
Caibin Zhao ◽  
...  
Keyword(s):  
Formic Acid ◽  
Unimolecular Reaction ◽  
Small Reduction ◽  
Biological Importance ◽  
Acid Catalyzed ◽  
Protonated Cytosine

Isomerization barrier for isolated unimolecular reaction is quite high, and its probability may be very small. Reduction of isomerization barrier is over 36 kJ mol−1 in going from H2O to HCOOH⋯H2O group catalysts.

scholarly journals Design and Synthesis of Hyperbranched Aromatic Polymers for Catalysis

Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1344 ◽  
Author(s):  
Yuta Nabae ◽  
Masa-aki Kakimoto
Keyword(s):  
Heterogeneous Catalysts ◽  
Aerobic Oxidation ◽  
Review Article ◽  
Linear Polymers ◽  
Design And Synthesis ◽  
Oxidation Of Alcohols ◽  
Aromatic Polymers ◽  
Acid Catalyzed ◽  
Ether Ketone ◽  
Catalyzed Reactions

Aromatic polymers such as poly(ether sulfone), poly(ether ketone), and polyimide have been widely used in industry due to their thermal, mechanical, and chemical stabilities. Although their application to catalysis has been limited, the introduction of a hyperbranched architecture to such aromatic polymers is effective in developing catalytic materials that combine the advantages of homogenous and heterogeneous catalysts. This review article overviews the recent progress on the design and synthesis of hyperbranched aromatic polymers. Several acid catalyzed reactions and the aerobic oxidation of alcohols have been demonstrated using hyperbranched aromatic polymers as catalysts. The advantage of hyperbranched polymers against linear polymers is also discussed.

scholarly journals A Chiral Sulfoxide-Based C–H Acid

Synlett ◽  
2021 ◽  
Author(s):  
Benjamin List ◽  
Denis Höfler ◽  
Karl Kaupmees ◽  
Ivo Leito
Keyword(s):  
Single Crystal ◽  
Lewis Acid ◽  
Absolute Configuration ◽  
X Ray ◽  
Design And Synthesis ◽  
High Acidity ◽  
Acid Catalyzed ◽  
Brønsted And Lewis Acid

We report the design and synthesis of a strong, chiral, enantiopure sulfoxide-based C–H acid. Single crystal X-ray analysis confirms the proposed structure and its absolute configuration. The new motif shows a high acidity and activity in Brønsted and Lewis acid catalyzed transformations. So far, only low enantioselectivities were achieved.

scholarly journals Correction: Formic acid catalyzed isomerization of protonated cytosine: a lower barrier reaction for tautomer production of potential biological importance

2017 ◽  
Vol 19 (48) ◽  
pp. 32741-32741
Author(s):  
Lingxia Jin ◽  
Mengdan Lv ◽  
Mengting Zhao ◽  
Rui Wang ◽  
Caibin Zhao ◽  
...  
Keyword(s):  
Formic Acid ◽  
Chem Phys ◽  
Biological Importance ◽  
Acid Catalyzed ◽  
Protonated Cytosine ◽  
Phys Chem Chem Phys

Correction for ‘Formic acid catalyzed isomerization of protonated cytosine: a lower barrier reaction for tautomer production of potential biological importance’ by Lingxia Jin et al., Phys. Chem. Chem. Phys., 2017, 19, 13515–13523.

Environmentally friendly approaches to the synthesis of new antibiotics from sugars

2012 ◽  
Vol 84 (3) ◽  
pp. 803-816 ◽  
Author(s):  
Nuno M. Xavier ◽  
Amélia P. Rauter
Keyword(s):  
Drug Discovery ◽  
Antimicrobial Agents ◽  
Environmentally Friendly ◽  
Design And Synthesis ◽  
Biological Importance ◽  
New Antibiotics ◽  
Synthetic Carbohydrate ◽  
Novel Structures ◽  
Antibiotic Agents

In light of the biological importance of carbohydrates and their role when present in antibiotic agents, the design and synthesis of carbohydrate-based antibiotics has occupied a prominent place in drug discovery. This review focuses on synthetic carbohydrate antimicrobial agents, giving special emphasis to novel structures easily accessible from readily available carbohydrate precursors.

Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

1975 ◽  
Vol 33 ◽  
pp. 450-451
Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Phosphate Buffer ◽  
Prostatic Carcinoma ◽  
Prostatic Acid Phosphatase ◽  
Chemotherapeutic Agents ◽  
Specific Substrate ◽  
Acid Phosphate ◽  
Lysosomal Acid ◽  
Design And Synthesis ◽  
New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

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