Kinetic study of the substitution reaction of benzyl chloride with triphenylphosphine to synthesize benzyltriphenylphosphonium chloride. Solvent effects

1988 ◽  
Vol 27 (4) ◽  
pp. 555-559 ◽  
Author(s):  
Maw Ling Wang ◽  
Anhong Liu ◽  
Jing Jer Jwo
Keyword(s):  
Kinetic Study ◽  
Solvent Effects ◽  
Substitution Reaction ◽  
Benzyl Chloride

scholarly journals Synergistic Experimental and Computational Investigation of the Bioorthogonal Reactivity of Substituted Aryltetrazines

2021 ◽  
Author(s):  
Umberto Battisti ◽  
Rocío García-Vázquez ◽  
Dennis Svatunek ◽  
Barbara Herrmann ◽  
Andreas Löffler ◽  
...  
Keyword(s):  
Kinetic Study ◽  
Solvent Effects ◽  
Rate Constants ◽  
Biomedical Applications ◽  
Aqueous Systems ◽  
Phenyl Substituent ◽  
Computational Investigation ◽  
Radiation Burden ◽  
Intrinsic Reactivity

Tetrazines (Tz) have been applied as bioorthogonal agents for various biomedical applications including pretargeted imaging approaches. In radioimmunoimaging, pretargeting increases the target-to-background ratio while simultaneously reducing the radiation burden. We have recently reported a strategy to directly 18F-label highly reactive tetrazines based on a 3-(3-fluorophenyl)-Tz core structure. Herein, we report a kinetic study on this versatile scaffold. A library of 40 different tetrazines was prepared, fully characterized, and investigated with emphasis on second order rate constants for the reaction with trans-cyclooctene (TCO). Our results reveal the effects of various substitution patterns and moreover demonstrate the importance of measuring reactivities in the solvent of interest, as click rates in different solvents do not necessarily correlate well. In particular, we report that tetrazines modified in 2-position of the phenyl substituent show high intrinsic reactivity towards TCO, which is diminished in aqueous systems by unfavorable solvent effects. The obtained results enable the prediction of the bioorthogonal reactivity and thereby facilitate the development of the next-generation of substituted aryltetrazines for in vivo application.

Kinetic study of thermolysis of diarylhomonaphthoquinones. Endo/exo substituent and solvent effects

2000 ◽  
pp. 135-141 ◽  
Author(s):  
Takumi Oshima ◽  
Kazushi Tamada ◽  
Hatsue Tamura ◽  
Toshikazu Nagai
Keyword(s):  
Kinetic Study ◽  
Solvent Effects

A mechanistic study on the SHi reaction at tin atoms in a radical cascade reaction

2015 ◽  
Vol 2 (6) ◽  
pp. 713-720 ◽  
Author(s):  
Akio Kamimura ◽  
Tatsuro Yoshinaga ◽  
Fumiaki Noguchi ◽  
Koichiro Miyazaki ◽  
Hidemitsu Uno
Keyword(s):  
Kinetic Study ◽  
Substitution Reaction ◽  
Cascade Reaction ◽  
Mechanistic Study ◽  
Radical Cascade ◽  
Radical Substitution ◽  
Radical Substitution Reaction

A kinetic study on the intramolecular direct radical substitution reaction on tin atoms was undertaken.

scholarly journals Mechanistic study on substitution reaction of a citrato(p-cymene)Ru(ii) complex with sulfur-containing amino acids

RSC Advances ◽  
2019 ◽  
Vol 9 (43) ◽  
pp. 25177-25183
Author(s):  
Sen-ichi Aizawa ◽  
Kohei Takizawa ◽  
Momoko Aitani
Keyword(s):  
Amino Acids ◽  
Reaction Mechanism ◽  
Kinetic Study ◽  
Substitution Reaction ◽  
Mechanistic Study ◽  
Sulfur Containing

Thorough kinetic study revealed characteristics of the reaction mechanism for arene ruthenium(ii) complexes with bio-related ligands.

The reaction of naphthalene with benzyl chloride over an MCM-41 solid acid catalyst: a kinetic study

2002 ◽  
Vol 232 (1-2) ◽  
pp. 265-276 ◽  
Author(s):  
Paolo Beltrame ◽  
Francesco Demartin ◽  
Giovanni Zuretti
Keyword(s):  
Kinetic Study ◽  
Benzyl Chloride ◽  
Solid Acid ◽  
Solid Acid Catalyst ◽  
Acid Catalyst ◽  
Mcm 41
Sign in / Sign up

Export Citation Format

Share Document