Recovery of Very Dilute Acetic Acid Using Ion Exchange

1995 ◽  
Vol 34 (7) ◽  
pp. 2464-2467 ◽  
Author(s):  
Frikkie L. D. Cloete ◽  
Arno P. Marais
Keyword(s):  
Acetic Acid ◽  
Ion Exchange

scholarly journals Ion-exchange-resin-catalyzed adamantylation of phenol derivatives with adamantanols: Developing a clean process for synthesis of 2-(1-adamantyl)-4-bromophenol, a key intermediate of adapalene

2012 ◽  
Vol 8 ◽  
pp. 227-233 ◽  
Author(s):  
Nan Wang ◽  
Ronghua Wang ◽  
Xia Shi ◽  
Gang Zou
Keyword(s):  
Acetic Acid ◽  
Ion Exchange ◽  
Sulfonic Acid ◽  
Exchange Resin ◽  
Ion Exchange Resin ◽  
Phenol Derivatives ◽  
Resin Catalyst ◽  
Acid Resin ◽  
Free Process ◽  
Sulfonic Acid Resin

A clean process has been developed for the synthesis of 2-adamantylphenol derivatives through adamantylation of substituted phenols with adamantanols catalyzed by commercially available and recyclable ion-exchange sulfonic acid resin in acetic acid. The sole byproduct of the adamantylation reaction, namely water, could be converted into the solvent acetic acid by addition of a slight excess of acetic anhydride during the work-up procedure, making the process waste-free except for regeneration of the ion-exchange resin, and facilitating the recycling of the resin catalyst. The ion-exchange sulfonic acid resin catalyst could be readily recycled by filtration and directly reused at least ten times without a significant loss of activity. The key intermediate of adapalene, 2-(1-adamantyl)-4-bromophenol, could be produced by means of this waste-free process.

scholarly journals Eine neue Methode zur Herstellung und Reinigung von 5-Methyltetrahydrofolsäure / A New Method for Preparation and Purification of 5-M ethyltetrahydrofolic Acid

1973 ◽  
Vol 28 (11-12) ◽  
pp. 650-652
Author(s):  
Harold Rüdiger ◽  
Reinhard Siede
Keyword(s):  
Acetic Acid ◽  
Folic Acid ◽  
Ion Exchange ◽  
Sodium Borohydride ◽  
Sodium Salt ◽  
Barium Salt ◽  
Borohydride Reduction ◽  
Methyl Derivative ◽  
Crude Product ◽  
Sodium Borohydride Reduction

Abstract 5-Methyltetrahydrofolic acid is prepared from folic acid by sodium borohydride reduction, reac­ tion with formaldehyde and reduction to the methyl derivative by sodium borohydride. The crude product is precipitated as barium salt which after having been converted to the sodium salt by ion exchange is adsorbed to QAE-Sephadex and eluted by different acetic acid gradients in subsequent chromatographies. This method allows to process gram quantities on reasonably small columns

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