Design of Optimal Operating Conditions of Simulated Moving Bed Adsorptive Separation Units

1995 ◽  
Vol 34 (1) ◽  
pp. 288-301 ◽  
Author(s):  
Giuseppe Storti ◽  
Renato Baciocchi ◽  
Marco Mazzotti ◽  
Massimo Morbidelli
Keyword(s):  
Operating Conditions ◽  
Simulated Moving Bed ◽  
Optimal Operating ◽  
Moving Bed ◽  
Adsorptive Separation

scholarly journals Online estimation of optimal operating conditions for simulated moving bed chromatographic processes

2019 ◽  
Vol 1602 ◽  
pp. 266-272 ◽  
Author(s):  
P. Suvarov ◽  
J.-W. Lee ◽  
A. Vande Wouwer ◽  
A. Seidel-Morgenstern ◽  
A. Kienle
Keyword(s):  
Operating Conditions ◽  
Simulated Moving Bed ◽  
Optimal Operating ◽  
Online Estimation ◽  
Moving Bed

Supercritical Fluid Extraction of Polygonum cuspidatum and Subsequent Isolation by Simulated Moving Bed Chromatography

2013 ◽  
Vol 704 ◽  
pp. 18-30
Author(s):  
Ming Tsai Liang ◽  
Ru Chien Liang ◽  
Shu Qi Yu ◽  
Ri An Yan ◽  
Ku Yuan Liang
Keyword(s):  
Carbon Dioxide ◽  
Crude Extract ◽  
Operating Conditions ◽  
Effect Of Temperature ◽  
Simulated Moving Bed ◽  
Polygonum Cuspidatum ◽  
Two Stage ◽  
Moving Bed ◽  
Second Stage ◽  
Simulated Moving Bed Chromatography

In this work, supercritical carbon dioxide with ethanol as cosolvent was employed to extract bioactive compounds fromPolygonum Cuspidatum. Effect of temperature for 40 and 50 C on the extraction at 35 MPa was examined. It was found that extraction at 50 C resulted in high yield. A two-stage extraction at 50 C and 35 MPa was then designed to investigate effect of cosolvent on the recovery of resveratrol and emodin. The first stage extraction by solely using carbon dioxide can rarely extract resveratrol, but adding ethanol as cosolvent in the second stage significantly increases the extraction of resverarol and emodin. The crude extract obtained in the second stage was very stable against agglomeration and precipitation, because the first stage extraction helped to remove impurities from thePolygonum Cuspidatum. The stable crude extract was subsequently used as the feed for the SMB (simulated moving bed) separation. In this work, experimental validation was completed by solely using single SMB to isolate resveratrol, emodin, and physcion from the crude extract. As conducting the SMB experiments, the Triangle theory was used to help to determine the separable operating conditions. From the discussion of the experimental results, the criterion to obtain the pure resveratrol and physcion, and the concentrated emodin were depicted. Since both the extraction and the purification are conducted at low temperature, the bioactivity of the produced natural products will totally be preserved. The two-stage extraction and subsequent purification in this paper will provide greener and effective alternative for the development of botanical drugs.

Improving the Operating Conditions of Gradient Ion-Exchange Simulated Moving Bed for Protein Separation

2013 ◽  
Vol 52 (15) ◽  
pp. 5407-5417 ◽  
Author(s):  
Xiaodan Wu ◽  
Harvey Arellano-Garcia ◽  
Weirong Hong ◽  
Günter Wozny
Keyword(s):  
Ion Exchange ◽  
Protein Separation ◽  
Operating Conditions ◽  
Simulated Moving Bed ◽  
Moving Bed

scholarly journals Multi-Objective Optimizations of Non-Isothermal Simulated Moving Bed Reactor: Parametric Analyses

Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 360
Author(s):  
Jian Wang ◽  
Wenwei Chen ◽  
Yan Li ◽  
Jin Xu ◽  
Weifang Yu ◽  
...  
Keyword(s):  
Optimization Problems ◽  
Optimal Solution ◽  
Simulated Moving Bed ◽  
Model Parameters ◽  
Feed Concentration ◽  
Moving Bed ◽  
Adsorptive Separation ◽  
Parametric Analyses ◽  
Rate Ratios ◽  
Isothermal Operation

Simulated moving bed reactor (SMBR), a multicolumn multifunctional integrated reactor system, which can be exploited with on-site adsorptive separation to enhance conversion of equilibrium-limited reversible chemical reaction. In this article, for generality, a dimensionless SMBR model was developed and effects of five representative temperature distributions among different zones on the performance of an SMBR for reversible reaction in the general form of a reactant decomposed to two products were evaluated based on simultaneous maximization of unit throughput and product purity. Multipliers were applied to adjust some of the model parameters such that different operation modes can be compared under various conditions in the parametric space. The multiobjective optimization problems were solved using the non-dominated sorting genetic algorithm. All simulations were carried out using FORTRAN codes. The results showed that both kinetics and adsorptive separation play important roles in SMBR. When kinetics is fast or adsorptive potency of the reactant is higher than the desired product (B) but lower than byproduct (C), non-isothermal operation can significantly improve unit throughput. On the contrary, feed concentration and reaction enthalpy have minor effects on the optimal solutions. Decision variables based on flow rate ratios and internal concentration profiles were used to explain the trends of Pareto optimal solution.

scholarly journals Simulated moving bed chromatography separation of galacto-oligosaccharides

2013 ◽  
Vol 6 (2) ◽  
pp. 206-210 ◽  
Author(s):  
Łukasz Wiśniewski ◽  
Monika Antošová ◽  
Milan Polakovič
Keyword(s):  
Cation Exchanger ◽  
Separation Efficiency ◽  
Packed Bed ◽  
Operating Conditions ◽  
Simulated Moving Bed ◽  
Moving Bed ◽  
Simulated Moving Bed Chromatography ◽  
Triangle Theory ◽  
Maximum Separation ◽  
Theoretical Plates

Abstract A mixture of galacto-oligosaccharides and non-prebiotic sugars was separated using a simulated moving bed unit equipped with eight packed-bed columns of a cation exchanger. In order to determine operating conditions using triangle theory, equilibrium adsorption isotherms of galactose, glucose, lactose, tri- and tetragalacto-oligosaccharide were measured. It was found that each column of the SMB unit had a maximum separation efficiency of more than 3000 theoretical plates. The achieved purity of galacto-oligosaccharides in the raffinate stream was 99.9 %, similarly 99.9 % of extract was formed by non-prebiotic sugars lactose, glucose and galactose. The productivities in the raffinate and extract, were 0.6 g/(L h) and 2.4 g/(L h), respectively.

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