Molecular Recognition of Long Dicarboxylate/Dicarboxylic Species via Supramolecular/Coordinative Interactions with Ditopic Receptors. Crystal Structure of {[Cu2L(H2O)2]⊃Pimelate}(ClO4)2

1999 ◽  
Vol 38 (4) ◽  
pp. 620-621 ◽  
Author(s):  
Carla Bazzicalupi ◽  
Andrea Bencini ◽  
Antonio Bianchi ◽  
Vieri Fusi ◽  
Enrique Garcia-España ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Molecular Recognition ◽  
Ditopic Receptors

scholarly journals A substrate selected by phage display exhibits enhanced side-chain hydrogen bonding to HIV-1 protease

2018 ◽  
Vol 74 (7) ◽  
pp. 690-694 ◽  
Author(s):  
Ian W. Windsor ◽  
Ronald T. Raines
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bonding ◽  
Molecular Recognition ◽  
Hydrogen Bonds ◽  
Phage Display ◽  
Directed Evolution ◽  
Side Chain ◽  
Endogenous Substrates ◽  
Hiv 1 ◽  
Additional Hydrogen

Crystal structures of inactive variants of HIV-1 protease bound to peptides have revealed how the enzyme recognizes its endogenous substrates. The best of the known substrates is, however, a nonnatural substrate that was identified by directed evolution. The crystal structure of the complex between this substrate and the D25N variant of the protease is reported at a resolution of 1.1 Å. The structure has several unprecedented features, especially the formation of additional hydrogen bonds between the enzyme and the substrate. This work expands the understanding of molecular recognition by HIV-1 protease and informs the design of new substrates and inhibitors.

Crystal structure of pyrogallol[4]arene complex with phosphocholine: A molecular recognition model for phosphocholine through cation–π interaction

2013 ◽  
Vol 1038 ◽  
pp. 188-193 ◽  
Author(s):  
Ikuhide Fujisawa ◽  
Yuji Kitamura ◽  
Rumi Okamoto ◽  
Kazutaka Murayama ◽  
Ryo Kato ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Molecular Recognition ◽  
Recognition Model ◽  
Arene Complex
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