Molecular Recognition of Sialic Acid by Lanthanide(III) Complexes through Cooperative Two-Site Binding

2010 ◽  
Vol 49 (9) ◽  
pp. 4212-4223 ◽  
Author(s):  
Martín Regueiro-Figueroa ◽  
Kristina Djanashvili ◽  
David Esteban-Gómez ◽  
Thomas Chauvin ◽  
Éva Tóth ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Molecular Recognition ◽  
Site Binding

scholarly journals Sialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Yuting Xiong ◽  
Ge Jiang ◽  
Minmin Li ◽  
Guangyan Qing ◽  
Xiuling Li ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Molecular Recognition ◽  
Macroscopic Property

Synthesis and labelling of a phenylboranate derivative with 68Ga for molecular recognition of overexpressed sialic acid on tumor cells

2019 ◽  
Vol 72-73 ◽  
pp. S40
Author(s):  
A. Shegani ◽  
M. Kaplanis ◽  
C. Kiritsis ◽  
M. Ischyropoulou ◽  
M. Vlastara ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Molecular Recognition ◽  
Tumor Cells

Molecular Recognition of Sialic Acid End Groups by Phenylboronates

2005 ◽  
Vol 11 (13) ◽  
pp. 4010-4018 ◽  
Author(s):  
Kristina Djanashvili ◽  
Luca Frullano ◽  
Joop A. Peters
Keyword(s):  
Sialic Acid ◽  
Molecular Recognition ◽  
End Groups

scholarly journals Molecular Recognition Insights of Sialic Acid Glycans by Distinct Receptors Unveiled by NMR and Molecular Modeling

2021 ◽  
Vol 8 ◽  
Author(s):  
Cátia Oliveira Soares ◽  
Ana Sofia Grosso ◽  
June Ereño-Orbea ◽  
Helena Coelho ◽  
Filipa Marcelo
Keyword(s):  
Sialic Acid ◽  
Molecular Modeling ◽  
Nmr Spectroscopy ◽  
Molecular Recognition ◽  
Complex Structure ◽  
Structural Features ◽  
Sialic Acids ◽  
Infection Process ◽  
Human Cells ◽  
Host Cells

All cells are decorated with a highly dense and complex structure of glycan chains, which are mostly attached to proteins and lipids. In this context, sialic acids are a family of nine-carbon acidic monosaccharides typically found at the terminal position of glycan chains, modulating several physiological and pathological processes. Sialic acids have many structural and modulatory roles due to their negative charge and hydrophilicity. In addition, the recognition of sialic acid glycans by mammalian cell lectins, such as siglecs, has been described as an important immunological checkpoint. Furthermore, sialic acid glycans also play a pivotal role in host–pathogen interactions. Various pathogen receptors exposed on the surface of viruses and bacteria are responsible for the binding to sialic acid sugars located on the surface of host cells, becoming a critical point of contact in the infection process. Understanding the molecular mechanism of sialic acid glycans recognition by sialic acid-binding proteins, present on the surface of pathogens or human cells, is essential to realize the biological mechanism of these events and paves the way for the rational development of strategies to modulate sialic acid-protein interactions in diseases. In this perspective, nuclear magnetic resonance (NMR) spectroscopy, assisted with molecular modeling protocols, is a versatile and powerful technique to investigate the structural and dynamic aspects of glycoconjugates and their interactions in solution at the atomic level. NMR provides the corresponding ligand and protein epitopes, essential for designing and developing potential glycan-based therapies. In this review, we critically discuss the current state of knowledge about the structural features behind the molecular recognition of sialic acid glycans by different receptors, naturally present on human cells or pathogens, disclosed by NMR spectroscopy and molecular modeling protocols.

scholarly journals Molecular recognition of sialoglycans by streptococcal Siglec-like adhesins: toward the shape of specific inhibitors

2021 ◽  
Author(s):  
Cristina Di Carluccio ◽  
Alba Silipo ◽  
Roberta Marchetti ◽  
Barbara Ben ◽  
Koichi Fukase ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Infective Endocarditis ◽  
Molecular Recognition ◽  
Oral Cavity ◽  
Commensal Bacteria ◽  
Streptococcus Gordonii ◽  
Healthy Individuals ◽  
Sialic Acid Binding ◽  
Specific Inhibitors

Streptococcus gordonii and sanguinis, commensal bacteria present in the oral cavity of healthy individuals, upon entry into the bloodstream can become pathogenic, causing infective endocarditis (IE). Sialic acid-binding serine-rich repeat...

129: Sialic Acid Content of Urinary TAMM-Horsfall Protein is Reduced in Interstitial Cystitis Patients

2007 ◽  
Vol 177 (4S) ◽  
pp. 44-45
Author(s):  
C. Lowell Parsons ◽  
Mahadevan Rajasekaran ◽  
Marianne Chenoweth ◽  
Paul Stein
Keyword(s):  
Sialic Acid ◽  
Interstitial Cystitis ◽  
Acid Content ◽  
Sialic Acid Content

Avian influenza and sialic acid receptors: more than meets the eye?

2005 ◽  
Vol 5 (3) ◽  
pp. 184-188 ◽  
Author(s):  
S OLOFSSON ◽  
U KUMLIN ◽  
K DIMOCK ◽  
N ARNBERG
Keyword(s):  
Sialic Acid ◽  
Avian Influenza ◽  
Sialic Acid Receptors
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