Synthesis of amino derivatives of sulfur tetrafluoride and phosphorus pentafluoride by silicon-nitrogen bond cleavage reactions

1967 ◽  
Vol 6 (10) ◽  
pp. 1903-1906 ◽  
Author(s):  
Gregory C. Demitras ◽  
Alan G. MacDiarmid
Keyword(s):  
Bond Cleavage ◽  
Amino Derivatives ◽  
Cleavage Reactions ◽  
Sulfur Tetrafluoride ◽  
Derivatives Of ◽  
Nitrogen Bond ◽  
Phosphorus Pentafluoride

Nitrogen-nitrogen bond cleavage reactions. Generation of ammonia and amines from substituted hydrazido(2-) complexes of tungsten

1993 ◽  
Vol 32 (6) ◽  
pp. 785-786 ◽  
Author(s):  
Jeffery R. D. DeBord ◽  
T. Adrian George ◽  
Yuanda Chang ◽  
Qin Chen ◽  
Jon Zubieta
Keyword(s):  
Bond Cleavage ◽  
Cleavage Reactions ◽  
Nitrogen Bond

C-N-, Si-N- und P-N-Bindungsspaltung bei der Umsetzung von Phosphorpentafluorid mit einem N-Trimethylsilyl-N-tert-butylamino-substituierten Fluorphosphin und Fluorphosphoran / C-N, Si-N and P-N Bond Cleavage in Reactions of Phosphorus Pentafluoride with a Fluoro-phosphine and a Fluorophosphorane, Containing the N-Trimethylsilyl-N-tert<-butyl Group

1980 ◽  
Vol 35 (9) ◽  
pp. 1125-1129 ◽  
Author(s):  
Gerd-Volker Röschenthaler ◽  
Werner Storzer ◽  
Reinhard Schmutzler
Keyword(s):  
Lone Electron Pair ◽  
Electron Pair ◽  
Bond Cleavage ◽  
Tert Butyl ◽  
Butyl Group ◽  
Tert Butyl Group ◽  
Cleavage Reactions ◽  
Phosphorus Pentafluoride

PF5 reacts with Mo3Si(But)NPF2(E) (E = lone electron pair or OC(CF3)2C(CF3)2O) to give products whose formation can be rationalised in terms of assuming the decomposition of the intermediates F4PN(But)PF2(E) into ButF and F3P = N-PF2(E). ButF, in the presence of PF5, trimerises to give a 1 : 1 mixture of tri-iso-butene isomers. During this reaction HF is formed, giving rise to additional Si-N and P-N bond cleavage reactions in which the compounds ButNHPF2, F3P(E), ButNH3+PF6- and NH4+PF6- are formed.

Synthesis, Docking Studies into CDK-2 and Anticancer Activity of New Derivatives Based Pyrimidine Scaffold and Their Derived Glycosides

2019 ◽  
Vol 19 (13) ◽  
pp. 1093-1110 ◽  
Author(s):  
Adel A.H. Abdel Rahman ◽  
Ibrahim F. Nassar ◽  
Amira K.F. Shaban ◽  
Dina S. EL-Kady ◽  
Hanem M. Awad ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Human Liver ◽  
Docking Studies ◽  
Cyclin Dependent Kinase ◽  
Binding Interaction ◽  
Enzyme Active Site ◽  
Human Liver Cancer ◽  
Amino Derivatives ◽  
Activity Behavior ◽  
Derivatives Of

Background & Objective:New diaryl-substituted pyrimidinedione compounds, their thioxo derivatives as well as their bicyclic thiazole compounds were synthesized and characterized.Methods:The glycosylamino derivatives of the synthesized disubstituted derivatives of the pyrimidine scaffold were also prepared via reaction of the N3-amino derivatives with a number of monosaccharides followed by acetylation.Results:The anticancer activity of the synthesized compounds was studied against human liver cancer (HepG2) and RPE-1cell lines. Compounds 2a, 2b, 3a and 12 showed potent activities with IC50 results comparable to that of doxorubicin.Conclusion:Docking investigations into Cyclin-dependent kinase 2 (CDK-2) enzyme, a potential target for cancer medication, were also reported showing the possible binding interaction into the enzyme active site to support their activity behavior.

Thermal cyclocondensations of 3-N(4- and 5-benzimidazolyl and benztriazolyl)amino derivatives of 2-propenoic acid

1987 ◽  
Vol 52 (12) ◽  
pp. 2918-2925 ◽  
Author(s):  
Viktor Milata ◽  
Dušan Ilavský
Keyword(s):  
Uv Spectra ◽  
Propenoic Acid ◽  
Amino Derivatives ◽  
Derivatives Of ◽  
C Nmr ◽  
Ir And Uv Spectra

The cyclization of 3-N(4- and 5-benzimidazolyl and benztriazolyl)amino-2-cyano- and 2-ethoxycarbonyl-2-propenoate esters Ia, b-IVa, b under the conditions of the Gould-Jacobs reaction leads to angularly ring-fused substituted imidazo or triazolo[4,5-f] (V, VI) and [4,5-h] (VII, VIII) quinolines, respectively. The esters Vb-VIIIb have been transformed into the corresponding chloroderivatives Vc-VIIIc. 3-N(5-Benzimidazolyl and 5-benztriazolyl)amino-2-cyano-2-propenenitriles are cyclized in the presence of aluminium(III) chloride to give the aminoquinolines Vd, VId. The structure of the products has been characterized by their 1H, 13C NMR, IR, and UV spectra.

Hydrogenation-dehydrogenation and cleavage functions of hydrorefining catalysts studied by the reaction of tetrahydrothiophene

1986 ◽  
Vol 51 (12) ◽  
pp. 2770-2780 ◽  
Author(s):  
Alexandra Drahorádová ◽  
Miroslav Zdražil
Keyword(s):  
Activated Carbon ◽  
Catalyst Surface ◽  
Bond Cleavage ◽  
Unsaturated Hydrocarbons ◽  
Cleavage Reactions

The reaction of tetrahydrothiophene in a stream of nitrogen was used to study the relations between dehydrogenation and C-S cleavage reactions on sulphided Co-Mo/Al2O3 catalysts. The course of the reaction was compared for Co-Mo catalysts supported on alumina and activated carbon, for alumina alone as well as for a Pt/C catalyst. The effect of substitution of nitrogen for hydrogen, of the addition of water to the feed, of pre-sulphidation of catalysts and their deactivation by coking on the rate and selectivity of the reaction were also investigated. The results showed that hydrogenation-dehydrogenation and dehydrosulphurization activity of the sulphide catalysts have the same origin. Hydrogen accelerates dehydrosulphurization on the sulphide catalysts by removing sulphur and unsaturated hydrocarbons formed on catalyst surface by C-S bond cleavage reactions.

Cleavage of the Epimines of 1,6-Anhydrohexoses with Fluoride Anion

2005 ◽  
Vol 70 (12) ◽  
pp. 2075-2085 ◽  
Author(s):  
Jiří Kroutil ◽  
Klára Jeništová
Keyword(s):  
Fluoride Anion ◽  
Ring Cleavage ◽  
Protecting Group ◽  
Reaction Conditions ◽  
Aziridine Ring ◽  
Cleavage Reactions ◽  
Derivatives Of ◽  
Fluoro Derivatives

Aziridine ring cleavage reactions of five N-nosylepimines (2-6) having D-talo, D-galacto, D-manno, and D-allo configurations with potassium hydrogendifluoride under various reaction conditions have been performed. The cleavage regioselectively afforded diaxial isomers of vicinal amino-fluoro derivatives of 1,6-anhydro-β-D-gluco- and mannopyranose 7-11 in 51-94% yields. Removal of 2-nitrobenzenesulfonyl protecting group with benzenethiol has been attempted in the case of compound 10.

ChemInform Abstract: Iron-Catalyzed Synthesis of Glycine Derivatives via Carbon-Nitrogen Bond Cleavage Using Diazoacetate.

ChemInform ◽  
2011 ◽  
Vol 42 (14) ◽  
pp. no-no
Author(s):  
Yoichiro Kuninobu ◽  
Mitsumi Nishi ◽  
Kazuhiko Takai
Keyword(s):  
Bond Cleavage ◽  
Glycine Derivatives ◽  
Nitrogen Bond
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