Influence of the Solvent and Metal Center on Supramolecular Chirality Induction with Bisporphyrin Tweezer Receptors. Strong Metal Modulation of Effective Molarity Values

2012 ◽  
Vol 51 (8) ◽  
pp. 4620-4635 ◽  
Author(s):  
Inmaculada C. Pintre ◽  
Simon Pierrefixe ◽  
Alex Hamilton ◽  
Virginia Valderrey ◽  
Carles Bo ◽  
...  
Keyword(s):  
Metal Center ◽  
Supramolecular Chirality ◽  
Effective Molarity ◽  
Chirality Induction

The More the Slower: Self-Inhibition in Supramolecular Chirality Induction, Memory, Erasure, and Reversion

2022 ◽  
Author(s):  
Jiecheng Ji ◽  
Xueqin Wei ◽  
Wanhua Wu ◽  
Chunying Fan ◽  
Dayang Zhou ◽  
...  
Keyword(s):  
Supramolecular Chirality ◽  
Chirality Induction

scholarly journals Chiral metal–macrocycle frameworks: supramolecular chirality induction and helicity inversion of the helical macrocyclic structures

2016 ◽  
Vol 7 (3) ◽  
pp. 2217-2221 ◽  
Author(s):  
Ryou Kubota ◽  
Shohei Tashiro ◽  
Mitsuhiko Shionoya
Keyword(s):  
Supramolecular Chirality ◽  
Chirality Induction

Homochiral metal–macrocycle frameworks have been synthesized through supramolecular chirality induction with the aid of enantiopure sugar-derived lactones.

Versatile Switching in Substrate Topicity: Supramolecular Chirality Induction in Di- and Trinuclear Host Complexes

2012 ◽  
Vol 18 (22) ◽  
pp. 6805-6810 ◽  
Author(s):  
Martha V. Escárcega-Bobadilla ◽  
Giovanni Salassa ◽  
Marta Martínez Belmonte ◽  
Eduardo C. Escudero-Adán ◽  
Arjan W. Kleij
Keyword(s):  
Supramolecular Chirality ◽  
Chirality Induction

Temperature Effect on Supramolecular Chirality Induction in Bis(zinc porphyrin)

2000 ◽  
Vol 122 (18) ◽  
pp. 4403-4407 ◽  
Author(s):  
Victor V. Borovkov ◽  
Juha M. Lintuluoto ◽  
Michiya Fujiki ◽  
Yoshihisa Inoue
Keyword(s):  
Temperature Effect ◽  
Zinc Porphyrin ◽  
Supramolecular Chirality ◽  
Chirality Induction

Stoichiometry-Controlled Supramolecular Chirality Induction and Inversion in Bisporphyrin Systems

2002 ◽  
Vol 4 (2) ◽  
pp. 169-171 ◽  
Author(s):  
Victor V. Borovkov ◽  
Juha M. Lintuluoto ◽  
Yoshihisa Inoue
Keyword(s):  
Supramolecular Chirality ◽  
And Inversion ◽  
Chirality Induction

Supramolecular chirality induction in bis(zinc porphyrin) by amino acid derivatives: Rationalization and applications of the ligand bulkiness effect

Chirality ◽  
2001 ◽  
Vol 13 (6) ◽  
pp. 329-335 ◽  
Author(s):  
Victor V. Borovkov ◽  
Naoyuki Yamamoto ◽  
Juha M. Lintuluoto ◽  
Takumi Tanaka ◽  
Yoshihisa Inoue
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Zinc Porphyrin ◽  
Supramolecular Chirality ◽  
Chirality Induction

Some Problems in the Oxidative Addition and Binding of an Ethylene to a Transition Metal Center.

1987 ◽  
Vol 6 (4) ◽  
pp. 902-902
Author(s):  
Jerome Silestre ◽  
Maria Calhorda ◽  
Roald Hoffman ◽  
Page Stoutland ◽  
Robert Bergman
Keyword(s):  
Transition Metal ◽  
Oxidative Addition ◽  
Metal Center

The First Coordination of an (α-Diazo)phosphine to a Transition-Metal Center

2003 ◽  
Vol 22 (7) ◽  
pp. 1358-1360 ◽  
Author(s):  
Emmanuelle Despagnet-Ayoub ◽  
Heinz Gornitzka ◽  
John Fawcett ◽  
Philip W. Dyer ◽  
Didier Bourissou ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Center

scholarly journals Molecular Dynamics of Cobalt Protoporphyrin Antagonism of the Cancer Suppressor REV-ERBβ

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3251
Author(s):  
Taufik Muhammad Fakih ◽  
Fransiska Kurniawan ◽  
Muhammad Yusuf ◽  
Mudasir Mudasir ◽  
Daryono Hadi Tjahjono
Keyword(s):  
Binding Site ◽  
Nuclear Receptor ◽  
Target Genes ◽  
Protoporphyrin Ix ◽  
Binding Energies ◽  
Metal Center ◽  
Complex Nature ◽  
Dynamic Simulations ◽  
Subtle Change ◽  
Cobalt Protoporphyrin

Nuclear receptor REV-ERBβ is an overexpressed oncoprotein that has been used as a target for cancer treatment. The metal-complex nature of its ligand, iron protoporphyrin IX (Heme), enables the REV-ERBβ to be used for multiple therapeutic modalities as a photonuclease, a photosensitizer, or a fluorescence imaging agent. The replacement of iron with cobalt as the metal center of protoporphyrin IX changes the ligand from an agonist to an antagonist of REV-ERBβ. The mechanism behind that phenomenon is still unclear, despite the availability of crystal structures of REV-ERBβ in complex with Heme and cobalt protoporphyrin IX (CoPP). This study used molecular dynamic simulations to compare the effects of REV-ERBβ binding to Heme and CoPP, respectively. The initial poses of Heme and CoPP in complex with agonist and antagonist forms of REV-ERBβ were predicted using molecular docking. The binding energies of each ligand were calculated using the MM/PBSA method. The computed binding affinity of Heme to REV-ERBβ was stronger than that of CoPP, in agreement with experimental results. CoPP altered the conformation of the ligand-binding site of REV-ERBβ, disrupting the binding site for nuclear receptor corepressor, which is required for REV-ERBβ to regulate the transcription of downstream target genes. Those results suggest that a subtle change in the metal center of porphyrin can change the behavior of porphyrin in cancer cell signaling. Therefore, modification of porphyrin-based agents for cancer therapy should be conducted carefully to avoid triggering unfavorable effects.

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