[Me4N](NiII(BEAAM)):  A Synthetic Model for Nickel Superoxide Dismutase That Contains Ni in a Mixed Amine/Amide Coordination Environment

2006 ◽  
Vol 45 (24) ◽  
pp. 9637-9639 ◽  
Author(s):  
Jason Shearer ◽  
Ningfeng Zhao
Keyword(s):  
Superoxide Dismutase ◽  
Coordination Environment ◽  
Synthetic Model ◽  
Nickel Superoxide Dismutase

Revealing the Position of the Substrate in Nickel Superoxide Dismutase: A Model Study

2011 ◽  
Vol 50 (13) ◽  
pp. 2946-2950 ◽  
Author(s):  
Daniel Tietze ◽  
Stephan Voigt ◽  
Doreen Mollenhauer ◽  
Marco Tischler ◽  
Diana Imhof ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Model Study ◽  
Nickel Superoxide Dismutase

scholarly journals Novel Tripeptide Model of Nickel Superoxide Dismutase

2010 ◽  
Vol 49 (2) ◽  
pp. 362-364 ◽  
Author(s):  
Mary E. Krause ◽  
Amanda M. Glass ◽  
Timothy A. Jackson ◽  
Jennifer S. Laurence
Keyword(s):  
Superoxide Dismutase ◽  
Nickel Superoxide Dismutase

New Insight into the Mode of Action of Nickel Superoxide Dismutase by Investigating Metallopeptide Substrate Models

2008 ◽  
Vol 15 (2) ◽  
pp. 517-523 ◽  
Author(s):  
Daniel Tietze ◽  
Hergen Breitzke ◽  
Diana Imhof ◽  
Erika Kothe ◽  
James Weston ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Mode Of Action ◽  
Nickel Superoxide Dismutase ◽  
Insight Into

scholarly journals pH Dependent Reversible Formation of a Binuclear Ni2 Metal-Center within a Peptide Scaffold

Inorganics ◽  
2019 ◽  
Vol 7 (7) ◽  
pp. 90 ◽  
Author(s):  
Brenna C. Keegan ◽  
Daniel Ocampo ◽  
Jason Shearer
Keyword(s):  
Oxidation Products ◽  
Planar Geometry ◽  
Water Ligand ◽  
Coordination Environment ◽  
Nitrogen Ligand ◽  
Square Planar ◽  
Nickel Superoxide Dismutase ◽  
Reversible Formation ◽  
X Ray Absorption ◽  
Structure Calculations

A disulfide-bridged peptide containing two Ni2+ binding sites based on the nickel superoxide dismutase protein, {Ni2(SODmds)} has been prepared. At physiological pH (7.4), it was found that the metal sites are mononuclear with a square planar NOS2 coordination environment with the two sulfur-based ligands derived from cysteinate residues, the nitrogen ligand derived from the amide backbone, and a water ligand. Furthermore, S K-edge X-ray absorption spectroscopy indicated that the two cysteinate sulfur atoms ligated to nickel are each protonated. Elevation of the pH to 9.6 results in the deprotonation of the cysteinate sulfur atoms, and yields a binuclear, cysteinate bridged Ni22+ center with each nickel contained in a distorted square planar geometry. At both pH = 7.4 and 9.6, the nickel sites are moderately air sensitive, yielding intractable oxidation products. However, at pH = 9.6, {Ni2(SODmds)} reacts with O2 at an ~3.5-fold faster rate than at pH = 7.4. Electronic structure calculations indicate that the reduced reactivity at pH = 7.4 is a result of a reduction in S(3p) character and deactivation of the nucleophilic frontier molecular orbitals upon cysteinate sulfur protonation.

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