Re(CO)3Complexes Synthesized via an Improved Preparation of Aqueousfac-[Re(CO)3(H2O)3]+as an Aid in Assessing99mTc Imaging Agents. Structural Characterization and Solution Behavior of Complexes with Thioether-Bearing Amino Acids as Tridentate Ligands

2005 ◽  
Vol 44 (15) ◽  
pp. 5437-5446 ◽  
Author(s):  
Haiyang He ◽  
Malgorzata Lipowska ◽  
Xiaolong Xu ◽  
Andrew T. Taylor ◽  
Maria Carlone ◽  
...  
Keyword(s):  
Amino Acids ◽  
Structural Characterization ◽  
Imaging Agents ◽  
Solution Behavior ◽  
Tridentate Ligands

Structural characterization of folded and extended conformations in peptides containing γ amino acids with proteinogenic side chains: crystal structures of γn, (αγ)n and γγδγ sequences

2015 ◽  
Vol 39 (5) ◽  
pp. 3319-3326 ◽  
Author(s):  
Madhusudana M. B. Reddy ◽  
K. Basuroy ◽  
S. Chandrappa ◽  
B. Dinesh ◽  
B. Vasantha ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Crystal Structures ◽  
Structural Characterization ◽  
Side Chains ◽  
Amino Acid Residues

γn amino acid residues can be incorporated into structures in γn and hybrid sequences containing folded and extended α and δ residues.

Potent cyclometallated Pd(ii) antitumor complexes bearing α-amino acids: synthesis, structural characterization, DNA/BSA binding, cytotoxicity and molecular dynamics simulation

2020 ◽  
Vol 49 (42) ◽  
pp. 14891-14907
Author(s):  
Sedigheh Abedanzadeh ◽  
Kazem Karami ◽  
Mostafa Rahimi ◽  
Masoud Edalati ◽  
Mozhgan Abedanzadeh ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Amino Acids ◽  
Molecular Modeling ◽  
Molecular Dynamics Simulation ◽  
Structural Characterization ◽  
Dynamics Simulation ◽  
Bsa Binding ◽  
Modeling Studies ◽  
Molecular Modeling Studies ◽  
Antitumor Complexes

Synthesis, characterization, spectroscopic, biological, and molecular modeling studies on the DNA/BSA binding interactions of new cyclometallated Pd(ii) complexes bearing α-amino acids were investigated.

scholarly journals Functional and structural characterization of IdnL7, an adenylation enzyme involved in incednine biosynthesis

2019 ◽  
Vol 75 (4) ◽  
pp. 299-306
Author(s):  
Jolanta Cieślak ◽  
Akimasa Miyanaga ◽  
Makoto Takaishi ◽  
Fumitaka Kudo ◽  
Tadashi Eguchi
Keyword(s):  
Amino Acids ◽  
Substrate Specificity ◽  
Natural Product ◽  
Structural Characterization ◽  
Biochemical Analysis ◽  
Natural Product Biosynthesis ◽  
Broad Substrate Specificity ◽  
Selective Incorporation ◽  
Polyketide Antibiotic

Adenylation enzymes play an important role in the selective incorporation of the cognate carboxylate substrates in natural product biosynthesis. Here, the biochemical and structural characterization of the adenylation enzyme IdnL7, which is involved in the biosynthesis of the macrolactam polyketide antibiotic incednine, is reported. Biochemical analysis showed that IdnL7 selects and activates several small amino acids. The structure of IdnL7 in complex with an L-alanyl-adenylate intermediate mimic, 5′-O-[N-(L-alanyl)sulfamoyl]adenosine, was determined at 2.1 Å resolution. The structure of IdnL7 explains the broad substrate specificity of IdnL7 towards small L-amino acids.

scholarly journals Inside Cover: Synthesis and Structural Characterization of Homochiral Homo-oligomers of Parent cis- and trans-Furanoid-β-Amino Acids (Chem. Eur. J. 46/2011)

2011 ◽  
Vol 17 (46) ◽  
pp. 12834-12834
Author(s):  
Sunil K. Pandey ◽  
Ganesh F. Jogdand ◽  
João C. A. Oliveira ◽  
Ricardo A. Mata ◽  
Pattuparambil R. Rajamohanan ◽  
...  
Keyword(s):  
Amino Acids ◽  
Structural Characterization ◽  
Cis And Trans

Synthesis and Structural Characterization of Homochiral Homo-Oligomers of cis-γ-Methoxy-Substituted cis- and trans-Furanoid-β-Amino Acids

2012 ◽  
Vol 2012 (13) ◽  
pp. 2656-2663 ◽  
Author(s):  
Awadut G. Giri ◽  
Ganesh F. Jogdand ◽  
Pattuparampil R. Rajamohanan ◽  
Sunil K. Pandey ◽  
Chepuri V. Ramana
Keyword(s):  
Amino Acids ◽  
Structural Characterization ◽  
Cis And Trans

scholarly journals Synthesis of Dianionic and Trianionic Chiral, Chelating Ligands Based on Amino Acids

2008 ◽  
Vol 61 (4) ◽  
pp. 297
Author(s):  
Madeleine Schultz ◽  
Jakov Kulis ◽  
Julie Murison ◽  
Genevieve W. Andrews
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Aspartic Acid ◽  
Nitrilotriacetic Acid ◽  
Solution Phase ◽  
Chelating Ligands ◽  
Bidentate Ligands ◽  
Synthetic Route ◽  
Tridentate Ligands ◽  
Amide Coupling

The synthesis of two new families of amino acid-containing chiral ligands, based on methyliminodiacetic acid and nitrilotriacetic acid cores, has been accomplished using a simple protection, solution-phase amide coupling, and deprotection strategy. The amino acids glycine, leucine, aspartic acid, and phenylalanine were used to demonstrate the versatility of the synthetic route, and that no epimerization occurs. The tridentate ligands bear C3 symmetry, whereas the bidentate ligands have C1 symmetry.

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