Design and evaluation of conjugated bridging .pi. systems. Molecular orbital characterization and electrochemical determination of the pentacarbonyltungsten binding site in two new ambidentate ligands

1990 ◽  
Vol 29 (10) ◽  
pp. 1898-1902 ◽  
Author(s):  
Wolfgang Kaim ◽  
Stephen Kohlmann
Keyword(s):  
Binding Site ◽  
Molecular Orbital ◽  
Electrochemical Determination ◽  
Pi Systems

Antithrombin-mediated Inhibition of Factor Vlla-Tissue Factor Complex by the Synthetic Pentasaccharide Representing the Heparin Binding Site to Antithrombin

1996 ◽  
Vol 76 (01) ◽  
pp. 005-008 ◽  
Author(s):  
Jean Claude Lormeau ◽  
Jean Pascal Herault ◽  
Jean Marc Herbert
Keyword(s):  
Binding Site ◽  
Tissue Factor ◽  
Residual Activity ◽  
Coagulation Factors ◽  
Heparin Binding ◽  
Experimental Conditions ◽  
First Order ◽  
Heparin Binding Site ◽  
Coagulant Activity

SummaryWe examined the effect of the synthetic pentasaccharide representing the minimal binding site of heparin to antithrombin on the antithrombin-mediated inactivation of factor Vila bound to tissue factor. This effect was compared to the effect of unfractionated heparin. Using purified recombinant human coagulation factors and either a clotting or an amidolytic assay for the determination of the residual activity of factor Vila, we showed that the pentasaccharide was an efficient antithrombin-dependent inhibitor of the coagulant activity of tissue factor-factor Vila complex. In our experimental conditions, assuming a mean MW of 14,000 for heparin, the molar pseudo-first order rate constants for ATIII-mediated FVIIa inhibition by ATIII-binding heparin and by the synthetic pentasaccharide were found to be similar with respective values of 104,000 ± 10,500 min-1 and 112,000 ± 12,000 min-1 (mean ± s.e.m., n = 3)

scholarly journals Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution

2021 ◽  
Vol 152 (2) ◽  
pp. 185-192
Author(s):  
Jelena Lović ◽  
Jelena Lađarević ◽  
Nemanja Trišović ◽  
Filip Andrić ◽  
Aleksandar Mladenović ◽  
...  
Keyword(s):  
Gold Electrode ◽  
Electrochemical Determination ◽  
Pharmaceutical Formulation

Electrochemical determination of SrFe12O19 impurity in perovskite ferrites

2021 ◽  
pp. 159677
Author(s):  
S.S. Nikitin ◽  
O.V. Merkulov ◽  
A.D. Bamburov ◽  
M.V. Patrakeev
Keyword(s):  
Electrochemical Determination

A New Voltammetric Approach for Electrochemical Determination of Lamotrigine in Pharmaceutical Samples

2021 ◽  
Author(s):  
Anton A. Ciucu ◽  
Mihaela Buleandră ◽  
Tatiana Ciurea ◽  
Vlad N. Stoica ◽  
Cristian D. Ştefanescu ◽  
...  
Keyword(s):  
Electrochemical Determination ◽  
Pharmaceutical Samples
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