Ammine ligand exchange in tetraamminegold(III) in aqueous solution. Composition of transition states and relative reactivity of tetraamminegold(III) and its conjugated base, amidotriamminegold(III)

1988 ◽  
Vol 27 (11) ◽  
pp. 1859-1862 ◽  
Author(s):  
Birthe Broennum ◽  
H. Saaby Johansen ◽  
L. H. Skibsted
Keyword(s):  
Aqueous Solution ◽  
Ligand Exchange ◽  
Transition States ◽  
Relative Reactivity ◽  
Solution Composition

scholarly journals Photoinduced Ligand Exchange Dynamics of a Polypyridyl Ruthenium Complex in Aqueous Solution

2021 ◽  
pp. 7278-7284
Author(s):  
Isabelle M. Dixon ◽  
Sylvestre Bonnet ◽  
Fabienne Alary ◽  
Jérôme Cuny
Keyword(s):  
Aqueous Solution ◽  
Ligand Exchange ◽  
Ruthenium Complex

scholarly journals Studies of Ruthenium Complexes. III. Kinetics of Isotopic Ligand-Exchange Reactions of Halogenopentaammineruthenium(III) Complexes in Aqueous Solution

1972 ◽  
Vol 45 (10) ◽  
pp. 3081-3083 ◽  
Author(s):  
Tetsuo Shinohara ◽  
Takato Yamada ◽  
Noriyuki Takebayashi ◽  
Shun-ichi Hiraki ◽  
Akira Ohyoshi
Keyword(s):  
Aqueous Solution ◽  
Ligand Exchange ◽  
Ruthenium Complexes ◽  
Exchange Reactions ◽  
Kinetics Of

scholarly journals Contribution of Dithiol Ligands to In Vitro and In Vivo Trypanocidal Activities of Dithiaarsanes and Investigation of Ligand Exchange in an Aqueous Solution

2000 ◽  
Vol 44 (11) ◽  
pp. 2954-2961 ◽  
Author(s):  
Philippe M. Loiseau ◽  
Patrick Lubert ◽  
Jean-Gerard Wolf
Keyword(s):  
Aqueous Solution ◽  
Ligand Exchange ◽  
Trypanosoma Brucei Brucei ◽  
Minimum Effective Concentration ◽  
Dihydrolipoic Acid ◽  
Trypanocidal Activity ◽  
Rapid Exchange ◽  
Intracellular Targets

ABSTRACT Twelve new dithiaarsanes were evaluated for their in vitro and in vivo trypanocidal properties in regard to their three parent molecules, 4-amino-phenylarsenoxide, melarsenoxide, and 4-dansylamino-phenylarsenoxide. The most potent dithiaarsane, compound 2b, had a minimum effective concentration of 1.5 nM after 48 h of incubation and at a dose of 0.39 μmol/kg of body weight (0.2 mg/kg) administered subcutaneously cured 100% of mice acutely infected withTrypanosoma brucei brucei CMP. With this model, the chemotherapeutic index of compound 2b was 512, compared to 256 for melarsamine dihydrochloride (Cymelarsan) under the same conditions. With a chronic infection produced by T. brucei brucei GVR, compound 2b cured 100% of mice after treatment at a dose of 25 μmol/kg (12.5 mg/kg) for 4 consecutive days, whereas melarsamine dihydrochloride and potassium melarsonyl (Trimelarsan) cured less than 50% mice at this dose. For both acute and late-stage infections, dithiaarsanes having a melaminophenyl ring exhibited the most-potent trypanocidal activity. Compound 2b is thus one of the most active organoarsenicals described in a mouse trypanosomiasis model. Considering that the main intracellular targets of organoarsenicals are thiol groups, we studied the possibility of ligand exchange between Cymelarsan and several dithiols. In aqueous solution, we observed a rapid exchange of cysteamine from melarsamine with free cysteamine and also with various dithiols always in favor of more stable cyclic derivatives. These ligand exchanges suggest the ability of trivalent organoarsenicals to react with targets such as trypanothione and dihydrolipoic acid. Among several ligands, a 1,3-dimercaptopropane moiety appeared the most suitable for trypanocidal activity.

Radiation-Induced Degradation and the Effect of Scavengers on Benzene, Monochlorobenzene and 1,2-Dichlorobenzene in Aqueous Solutions

2004 ◽  
Vol 39 (3) ◽  
pp. 245-251 ◽  
Author(s):  
Salaheddin Takriti
Keyword(s):  
Aqueous Solution ◽  
High Performance ◽  
Degradation Rate ◽  
Complex Mixture ◽  
Reaction Rates ◽  
Solution Composition ◽  
Halogenated Benzenes ◽  
Radiation Induced ◽  
Rapid Reaction ◽  
By Products

Abstract The degradation of benzene, monochlorobenzene and 1,2-dichlorobenzene in aqueous solution by gamma irradiation was investigated. The effect of the irradiated solution composition was studied. The results showed that benzene is more resistant to destruction than chlorinated benzenes. The presence of oxidizing and reducing reactive species and the rapid reaction rates with halogenated benzenes increased the degradation rate of the pollutants. Dechlorination of CB and 1,2-DCB was observed. High performance liquid chromatography (HPLC) and spectroscopy (UV-Vis) were used to monitor changes in the radiation solutions. The final aqueous irradiation products were shown to be a complex mixture of by-products. The addition of scavengers such as methanol and ethanol required larger doses to decompose the pollutants when compared to those solutions with no additives.

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